Cross-conjugated vinylogous annulation of π-CF-allyl Pd-complexes with 4-methyl-3-trifluoroacetyl-quinolones.

Herein, we disclose the hitherto unknown cross-conjugated vinylogous annulation of π-CF-allyl Pd complexes with 4-methyl-3-trifluoroacetyl-quinolones to access phenanthridones. The CF group in the Pd-π-allyl complex is key for exclusive γ-regioselectivity and further annulation. The solvent switch orchestrates the dihydro-phenanthridones (CHCN) and hydroxy-phenanthridones (DMF) in good yields, and also showed excellent optoelectronic properties.

Glucocorticoid receptor mediated sensitization of colon cancer to photodynamic therapy induced cell death.

Photodynamic therapy (PDT) is a clinically approved, non-invasive alternate cancer therapy. A synthetic glucocorticoid (GC), dexamethasone (Dex) has previously been demonstrated to sensitize cancer cells to chemotherapy. However, to the best of our knowledge, the sensitization effect of GCs on PDT has not yet been investigated.

Phenothiazine functional materials for organic optoelectronic applications.

Phenothiazine (PTZ) is one of the most extensively investigated S, N heterocyclic aromatic hydrocarbons due to its unique optical, electronic properties, flexibility of functionalization, low cost, and commercial availability. Hence, PTZ and its derivative materials have been attractive in various optoelectronic applications in the last few years. In this prospective, we have focused on the most significant characteristics of PTZ and highlighted how the structural modifications such as different electron donors or acceptors, length of the π-conjugated system or spacers, polar or non-polar chains, and other functional groups influence the optoelectronic properties.