Immigration reform and the health of Latino immigrants in California.

This paper examines Latino immigrant health within the context of the current debate over immigration reform and the resulting cultural construction of public health in California. A review of epidemiologic and ethnographic data indicates that the subordinate socioeconomic status of Latino immigrants plays a major role in both disease etiology and access to health services. However, this status does not explain why certain patterns of health services utilization and disease morbidity and mortality persist although political and economic circumstances have changed.

Sandwich type ELISA and a fluorescent cytometric microbead assay for quantitative determination of hepatitis B virus X antigen level in human sera.

The hepatitis B virus X protein (HBxAg) is responsible for severe complications of HBV infections including primary hepatocellular carcinoma. A sandwich type ELISA and a flow cytometric microbead assay for quantitative determination of serum levels of Hbx-Ag are introduced. We have previously developed monoclonal antibody families against well-conserved epitopes on HbxAg, characterized by different immunohistochemical and immunoserological techniques.

Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.

The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha.

Models of research-operational collaboration for behavioral health in space.

Addressing the behavioral health needs of astronauts clearly requires collaborations involving researchers, clinicians and operational support personnel, program administrators, and the astronauts themselves. However, such collaborations are often compromised by a failure to understand the needs, priorities, constraints, and preferences of potential collaborators. This failure, in turn, can lead to research of poor quality, implementation of programs and procedures that are not evidence-based, and an increased risk of morbidity and mission failure.

Influence of seasonally adjusted exposure to cold and darkness on cognitive performance in circumpolar residents.

The effects of seasonally adjusted 24-h exposure to cold and darkness on cognitive performance in urban circumpolar residents was assessed in 15 male subjects who spent three 24-h periods in a climatic chamber at 65 degrees latitude during the winter (January-March) and/or summer (August-September). Each subject was exposed to three different environmental conditions in random order: (1) 22 degrees C temperature and 500 lx lighting; (2) 10 degrees C temperature and 500 lx lighting; and (3) 10 degrees C temperature and 0.5-l lx lighting.

Monoclonal antibodies identify four distinct annelid leukocyte markers.

This paper describes for the first time the production and characterization of a library of monoclonal antibodies (anti-EFCC clones) raised against coelomocyte (leukocyte) markers of Eisenia fetida earthworm. Leukocyte subgroups are components of earthworm innate immunity that require a more precise characterization using immunological markers. Flow cytometry, immunocytochemistry, and immunoprecipitation analyzed and confirmed the specificity of anti-EFCC clones.

Cross-cultural differences in psychosocial adaptation to isolated and confined environments.

Introduction: Differences in patterns of psychosocial adaptation under conditions of prolonged isolation and confinement in Antarctica were examined to determine the extent to which they were influenced by national culture in general and the individualist-collectivist orientation of national cultures in particular.

Methods: The Profile of Mood States and measures of structural and functional social support were administered over an 8-mo period (March through October) to 13 winter-over crews from 5 nations operating research stations in the Antarctic: United States (3 crews, n = 77), Poland (3 crews, n = 40), Russia (3 crews, n = 34), China (3 crews, n = 40), and India (1 crew, n = 26).

Results: Americans at South Pole Station reported significant increases in fatigue and anxiety and a significant decrease in vigor over the winter.

Seasonal changes in thermal responses of urban residents to cold exposure.

To determine whether urban circumpolar residents show seasonal acclimatisation to cold, thermoregulatory responses and thermal perception during cold exposure were examined in young men during January-March (n=7) and August-September (n=8). Subjects were exposed for 24 h to 22 and to 10 degrees C. Rectal (T(rect)) and skin temperatures were measured throughout the exposure.

A prospective study of Type 2 diabetes and depressive symptoms in the elderly: the Rancho Bernardo Study.

Aims: The association between Type 2 diabetes and depressive symptoms was examined prospectively to assess possible causal relationships between the two diseases.

Methods: A cohort of 971 men and women aged 50 and older from the adult population of Rancho Bernardo, California had an oral glucose tolerance test and completed the Beck Depression Inventory (BDI) at two clinic visits, 1984-87 and 1992-96.

Results: Depressive symptoms at baseline were associated with higher follow-up levels of non-fasting plasma glucose (P = 0.

The San Diego East County school shootings: a qualitative study of community-level post-traumatic stress.

Introduction: Within one month (March 2001), two separate incidents of school shootings occurred at two different high schools within the same school district in San Diego's East County.

Objective: To examine community-wide expressions of post-traumatic distress resulting from the shootings that may or may not fulfill DSM-IV criteria for post-traumatic stress disorder (PTSD), but which might interfere with treatment and the prevention of youth violence.

Methods: A qualitative study was undertaken using Rapid Assessment Procedures (RAP) in four East San Diego County communities over a six-month period following the two events.

Ethnic differences in symptoms of post-traumatic stress after the Exxon Valdez oil spill.

Introduction: Previous studies have reported ethnic differences in the prevalence of post-traumatic stress disorder (PTSD), but the reasons for these differences remain unclear.

Hypothesis: Ethnic differences in the prevalence of PTSD may reflect ethnic differences in (1) exposure to traumatic events; (2) appraisal of such event as traumatic; and (3) culturally-determined responses to standardized diagnostic instruments, reflecting differences in cultural meanings associated with physical symptoms and idioms of distress.

Methods: Ethnic differences in risk factors and factor structures of PTSD symptoms were examined in 188 Alaskan Natives and 371 Euro-Americans exposed to the Exxon-Valdez oil spill in 1989.

Incidence of psychiatric disorders after extended residence in Antarctica.

Objectives: The incidence of psychiatric disorders and depressive symptoms was examined in a cohort of American men and women who spent an austral winter at two different research stations in Antarctica to determine whether extended residence of nonindigenous inhabitants in a polar region is associated with psychiatric morbidity.

Study Design: Debriefings interviews with 220 men and 93 women were conducted by 3 psychiatrists and 1 clinical psychologist at McMurdo Station and South Pole Station at the end of the austral winter between 1994 and 1997. Crewmembers were assigned a DSM-IV diagnosis if they satisfied diagnostic criteria.

Earthworm leukocyte populations specifically harbor lysosomal enzymes that may respond to bacterial challenge.

Earthworm leukocytes (coelomocytes) are responsible for innate cellular immune functions such as phagocytosis and encapsulation against parasites and pathogens. Microbial killing results from the combined action of the phagocytic process with humoral immune factors such as agglutinins (e.g.

Elevation in serum thyroglobulin during prolonged Antarctic residence: effect of thyroxine supplement in the polar 3,5,3'-triiodothyronine syndrome.

Extended Antarctic residence (AR) is associated with an increase in serum TSH, a decrease in free T(4), and an increase in T(3) production and clearance. It is not clear whether these adaptations reflect changes in clearance alone or whether intrinsic thyroidal synthetic activity also changes. Thyroglobulin (Tg) secretion is an independent marker of intrinsic thyroid activity whose kinetics are independent of those of T(3) and T(4).

Social roles and the evolution of networks in extreme and isolated environments.

This article reports on the evolution of network structure as it relates to formal and informal social roles in well-bounded, isolated groups. Research was conducted at the Amundsen-Scott South Pole Station. Data were collected on crewmembers' networks of social interaction over each of three winter-over periods, when the station is completely isolated.

Social support and depressed mood in isolated and confined environments.

The influence of isolation and confinement on social support and depressed mood was examined in a study of 235 men and women who spent a year at McMurdo Station in Antarctica, and a study of 77 men and women who spent a year at the Amundson-Scott South Pole Station. Although availability of support remained unchanged, there was a significant decrease in reported satisfaction with support obtained, as well as a significant increase in depressed mood. Satisfaction with support was inversely associated with depressed mood at the beginning and end of isolation and confinement.

Antigen and glucocorticoid hormone (GC) induce positive selection of DP thymocytes in a TcR transgenic mouse model.

Thymocyte maturation in the thymus is controlled by stromal and humoral components. Among the humoral regulators locally produced glucocorticoids (GCs) seem to have a key role in the positive selection of thymocytes. Our previous studies have shown that the administration of GCs or the stimulation through the CD3 complex can induce apoptosis of double positive (DP) cells, but the combined presence of these stimuli induces positive selection.

Effect of the Antarctic environment on hormone levels and mood of Chinese expeditioners.

Background: Serum thyroid hormones, plasma catecholamines and mood were examined in 10 male members of the 16th Chinese Antarctic Expedition who spent the 2000 austral winter at Great Wall Station.

Study Design: Samples were taken prior to deployment to Antarctica (December, 1999) and upon return to China 54 weeks later (December, 2000). The expeditioners also completed the Profile of Mood States (POMS) each month over an 8-month period (April through November, 2000).

The journey to wellness: stages of refugee health promotion and disease prevention.

Refugees experience a threefold challenge to their health and well-being: 1) psychiatric disorders precipitated by the refugee experience, 2) infectious and parasitic diseases endemic to countries of origin, and 3) chronic diseases endemic to host countries. This paper documents the "journey to wellness" in which these challenges are faced in stages by the refugees themselves and by the array of health and social service agencies committed to providing refugee assistance. Using the experience of a consortium of agencies in San Diego as an example, we examine the interaction between these challenges and the mobilization of organizations to develop a program of health promotion and disease prevention for Somali and other East African refugees.

Youth-violence prevention in the aftermath of the San Diego East county school shootings: a qualitative assessment of community explanatory models.

Background: In March, 2001, 2 separate incidents of school shootings occurred within the same school district in San Diego's East County.

Objective: To examine community explanatory models of the causes of the school shootings and strategies for preventing such events.

Design/methods: A qualitative study was undertaken in 4 East County communities over a 6-month period following the 2 events.

The psychology of isolated and confined environments. Understanding human behavior in Antarctica.

Psychosocial adaptation to isolated and confined environments exhibits 4 distinct characteristics. First, it is seasonal: Variations in mood are associated with the altered diurnal cycle and psychological segmentation of the mission. Second, it is situational: Concurrent measures of personality, interpersonal needs, and coping styles are better predictors of mood and performance than are predeployment measures.

Efficacy of transdermal ketoprofen for delayed onset muscle soreness.

Objective: To determine the efficacy of transdermal ketoprofen in reducing delayed-onset muscle soreness (DOMS), limiting systemic absorption, and improving postexercise function following repetitive muscle contraction.

Design: Double-blind, placebo-controlled clinical trial.

Setting: OrthoMed, University of California at San Diego, La Jolla, CA, U.

Galactoside-specific misletoe lectin modulates dexamethasone-induced apoptosis and glucocorticoid receptor level in Balb/c thymocytes.

The galactoside-specific plant lectin, Viscum album agglutinin-(VAA)-I has been shown to activate the natural immune system and modulate the maturation of thymocytes in vivo. However the mechanism of this immunobiological action is not yet understood. In our previous study we demonstrated the VAA-I-induced enhancement of proliferation and selection of thymocytes which inhibited the dexamethasone (DX)-induced thymocyte depletion.