Clinical Manifestations.

Background: Evidence from multiple converging sources has demonstrated the clear benefits of physical activity in promoting mental health and improving cognitive function. However, more than 54% of Indians do not engage in the recommended amount of physical activity. The present study aims to explore the association of physical activity with cognitive abilities among the elderly aging population in an urban Indian setting.

Clinical Manifestations.

Background: Frailty, synonymous with physical vulnerability and decline, may exert nuanced effects on cognitive functions.(Borges, Canevelli, Cesari, & Aprahamian, 2019) This study assesses possible association between frailty and cognitive performance with the aim of identifying vulnerable cognitive domains.

Method: We analysed the baseline data from Tata Longitudinal Study of Ageing (TLSA)(Sundarakumar et al.

Clinical Manifestations.

Background: Dementia, a global health challenge, drives the need for comprehensive understanding. Longitudinal cohort studies are vital, yet maintaining follow-up in dementia cohorts poses challenges. This study explores challenges in follow-up, refines protocols, and develops strategies that can elevate dementia research quality.

Clinical Manifestations.

Background: Refractive errors are common visual comorbidities among the elderly. Cognitive dysfunction also occurs in this population. A study by Ong et al (2013) demonstrated an association of refractive errors with poor cognitive performance.

Clinical Manifestations.

Background: Cognitive control deficits can be early indicators of cognitive decline in individuals. Studies have found a bilingual advantage in cognitive control, however, there is little research on the Indian population, particularly those residing in rural areas. We aimed to investigate how cognitive control is influenced by the number of languages known to individuals among the aging population in both urban and rural settings in South India.

Clinical Manifestations.

Background: Visuo-cognitive skills represent a network of different abilities that rely on vision and cognition. While visuo-cognitive abilities have been considered prominent indicators of dementia, there is a dearth of studies that profile these abilities with demographic correlates in an aging Indian population. Investigating the pattern of visuo-cognitive abilities is essential to facilitate early indication, better prognosis and treatment of symptoms.

Clinical Manifestations.

Background: Pulmonary Function Tests (PFTs) are the non-invasive tests to measure the lung function. Relationship between pulmonary function and cognition is an emerging area of research, understanding this is crucial for prevention and management of dementia. Hence this study aims to investigate the association between pulmonary function and cognition.

Clinical Manifestations.

Background: Auditory attention and memory are the understudied aspects of cognition. Poor performance on cognitive tasks is assumed to be due to peripheral hearing loss, which is not always the case. Auditory processing issues may affect the auditory recall and attention tasks even though the hearing and cognition are normal.

Intraclass Correlation in Cluster Randomized Controlled Trials: A Meta-Analysis of Studies on Major Depression.

Background: Though cluster randomized trials (CRTs) provide robust evidence for intervention by controlling contamination of interventions, there could be some loss of statistical efficiency. The Consolidated Standards of Reporting Trials (CONSORT) recommends reporting intraclass correlation coefficients (ICC) to understand this phenomenon, though not many studies follow this. This meta-analysis explored the compliance of CRTs in major depression for reporting ICC besides deriving the pooled ICC and pooled mean differences of intervention outcomes.

Non-opioid psychiatric medications for chronic pain: systematic review and meta-analysis.

Background: The escalating number of deaths related to opioid usage has intensified the pursuit of non-opioid alternatives for managing chronic pain. It's often observed that psychiatric comorbidities coexist in patients suffering from chronic pain. There are a variety of psychotropic medications that have demonstrated effectiveness in treating both psychiatric symptoms and pain.

Distribution of biochemical and haematological parameters in an aging population from southern India: A cross-sectional analysis.

Background: Examining the distribution of biochemical and haematological tests in different age groups of rural population is necessary to ensure that health care facilities are equipped to address the prevalent health conditions and manage age-related illness effectively. Hence, this study is aimed at seeing the distributions of blood biochemical and haematological parameters in rural population.

Methods: This cross-sectional study investigated the distribution of 26 different haematological and biochemical parameters in longitudinal cohort study (Srinivaspura Aging, NeuoSenescence and COGnition - SANSCOG), from the villages of Srinivaspura, Kolar district, India.

Alteration in amygdala subfield volumes and their association with cognition in mild cognitive impairment.

Background: The amygdala has an important role in cognitive and affective functions. The involvement of amygdala and related limbic structures is implicated in many aspects of memory and emotion in mild cognitive impairment (MCI). In the present study, we aimed to compare the volumetric measurements of amygdala and its subfields as well as their association with cognitive functions in stable MCI (sMCI).

Dysregulated Cerebrospinal Fluid Proteome of Spinocerebellar Ataxia Type 2 and its Clinical Implications.

Background: Abnormalities in ataxin-2 associated with spinocerebellar ataxia type 2 (SCA2) may lead to widespread disruptions in the proteome. This study was performed to identify dysregulated proteome in SCA2 and to explore its clinical-radiological correlations.

Methods: Cerebrospinal fluid (CSF) samples from 21 genetically confirmed SCA2 were subjected to shotgun proteome analysis using mass spectrometry (MS) and tandem mass tag (TMT)-based multiplexing.

Transcranial direct current stimulation-efficacy in mild cognitive impairment: A meta-analysis.

Objectives: Mild cognitive impairment (MCI) is a transition state in which individuals have cognitive abilities that are in between those of normal aging and dementia. Although not everyone with MCI develops dementia, the risk of progression to dementia is higher in people with MCI. Interventions at this stage can prevent or delay the onset of dementia.

Therapeutic Potential of Buprenorphine in Depression: A Meta-Analysis of Current Evidence.

Background: Emerging research indicates buprenorphine, used in management of opioid use disorder, has attracted interest for its potential in treating a variety of psychiatric conditions. This meta-analysis aimed to determine the efficacy of buprenorphine in treating symptoms of depression.

Methods: Using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, a search was conducted of several databases until April 25, 2022, for English language articles related to buprenorphine and its use in treating various mental health conditions.

Association between multilingualism and cognitive performance among older adults in rural southern India.

Objectives: Recent studies have shown that multilingualism may play an important role in enhancing cognitive health. The process of language acquisition constitutes a form of natural brain training, which in turn is hypothesized to increase neuroplasticity and hence, maintains the cognitive reserve. The study aimed to analyze the relationship between the number of languages known to an individual and its effect on cognitive functioning in both healthy and cognitively impaired study participants.

Comparative efficacy of repetitive transcranial magnetic stimulation protocols for obsessive-compulsive disorder: A network meta-analysis.

Background: Repetitive transcranial magnetic stimulation (rTMS) has been found to be helpful for the treatment of obsessive-compulsive disorder (OCD). However, the relative efficacy of different rTMS protocols is unclear.

Objective: To conduct a systematic review and network meta-analysis (NMA) of published literature to compare the relative efficacy of different rTMS protocols for decreasing Yale-Brown Obsessive Compulsive Severity (Y-BOCS) scores in patients with OCD.

Effectiveness of Short-Term Lifestyle Modification on Reducing Body- Weight-Related Parameters in Persons with Severe Mental Illness: A Randomized Controlled Trial.

Background: Persons with severe mental illness (SMI) reportedly have a high mortality rate due to metabolic syndrome (MS). However, lifestyle modification (LM) offers effective management of some components of MS. This study aimed to evaluate the effectiveness of LM in reducing body-weight-related parameters in SMIs.

Impact of the COVID-19 pandemic on some modifiable risk factors of dementia in an aging, rural Indian population.

Introduction: The impact of the COVID-19 pandemic and associated lockdowns is likely to have caused adverse changes in lifestyle-related/cardiovascular risk factors and other such modifiable risk factors of dementia. We aimed to examine the pandemic's impact on some modifiable risk factors of dementia among rural Indians belonging to a large, prospective aging cohort-Srinivaspura Aging, NeuoSenescence, and COGnition (SANSCOG).

Methods: This was a cross-sectional study among adults aged ≥ 45 years ( = 3,148; 1,492 males and 1,656 females) residing in the villages of Srinivaspura in Karnataka state, India.

Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort.

Women carry a higher burden of Alzheimer's disease (AD) compared to men, which is not accounted entirely by differences in lifespan. To identify the mechanisms underlying this effect, we investigated sex-specific differences in the progression of familial AD in humans and in APPswe/PS1ΔE9 mice. Activity dependent protein translation and associative learning and memory deficits were examined in APPswe/PS1ΔE9 mice and wild-type mice.

Multivariate Bayesian Arm-Based Network Meta-Analysis of Pharmacological Interventions for the Treatment of Acute Bipolar Mania in Adults.

Background: In a network meta-analysis (NMA), multiple treatments can be compared simultaneously by aggregating pieces of evidence from direct as well as indirect treatment comparisons in different randomized controlled trials (RCTs). Conventional NMA are performed using a normal approximation approach and can be applied for arm-level binary outcome data as well. This study aimed to estimate the treatment effects within a Bayesian framework using a binomial likelihood for a multivariate NMA model.