Publications by authors named "Palaniappan Sashikumar"
Article Synopsis
- This study investigates the safety and effectiveness of whole-body hypothermia in neonates who have experienced mild hypoxic-ischemic encephalopathy (HIE), as existing data mainly focuses on cases of more severe illness.* -
- Conducted as a randomized clinical trial across six neonatal intensive care units in the UK and Italy, 101 eligible neonates were assigned to either normothermia or different durations of hypothermia (48 or 72 hours) based on their age after birth.* -
- The study primarily measures the concentration of thalamic N-acetyl aspartate through MRI to assess the impact of hypothermia on brain health, revealing specific outcomes in the treatment groups.*
Background: In neonatal encephalopathy, the clinical manifestations of injury can only be reliably assessed several years after an intervention, complicating early prognostication and rendering trials of promising neuroprotectants slow and expensive. We aimed to determine the accuracy of thalamic proton magnetic resonance (MR) spectroscopy (MRS) biomarkers as early predictors of the neurodevelopmental abnormalities observed years after neonatal encephalopathy.
Methods: We did a prospective multicentre cohort study across eight neonatal intensive care units in the UK and USA, recruiting term and near-term neonates who received therapeutic hypothermia for neonatal encephalopathy.
Neonatal adrenal haemorrhage presenting as scrotal haematoma.
Arch Dis Child Fetal Neonatal Ed
March 2011
Undifferentiated embryonal sarcoma is the uncommon malignant mesenchymal tumor of the liver seen in children and young adults. Radiologic findings reflect the solid to cystic appearances observed in the gross specimens. The discrepancy in the appearances of the mass between the ultrasound scan and computed tomography scan is the hall mark of this tumor.
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