Publications by authors named "Palade M"
Aflatoxin B1 (AFB1) is a mycotoxin that frequently contaminates cereals and cereal byproducts. This study investigates the effect of AFB1 on the mesenteric lymph nodes (MLNs) of piglets and evaluates if a diet containing grape seed meal (GSM) can counteract the negative effect of AFB1 on inflammation and oxidative stress. Twenty-four weaned piglets were fed the following diets: Control, AFB1 group (320 μg AFB1/kg feed), GSM group (8% GSM), and AFB1 + GSM group (8% GSM + 320 μg AFB1/kg feed) for 30 days.
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- The study aimed to evaluate how grape seed byproduct could help reduce the negative effects of aflatoxin B1 (AFB1) on the health of weaned piglets, particularly concerning their plasma, liver, and gastrointestinal tract.
- Twenty-four crossbred pigs were divided into four diet groups: a control, an AFB1-contaminated feed, a grape seed meal diet, and a combination of AFB1 and grape seed feed, over a period of 30 days.
- Results indicated that AFB1 caused significant health issues, but adding grape seed meal improved the pigs’ antioxidant enzyme activity, reduced inflammation, and ultimately enhanced growth performance despite the presence of AFB1.
A comparison between the effects of ochratoxin A and aristolochic acid on the inflammation and oxidative stress in the liver and kidney of weanling piglets.
Naunyn Schmiedebergs Arch Pharmacol
October 2018
Ochratoxin A (OTA) and aristolochic acid (AA) are toxins that can frequently contaminate cereals and cereals-based products. The present study has realized a comparison between the effect of OTA and AA on oxidative stress and inflammation in both the liver and kidney of pigs as major organs involved in the metabolism of xenobiotics. Fifteen pigs (five pigs/group) were randomly distributed in three groups (control, OTA, and AA) and were fed diets contaminated or not with 250 μg toxin/kg for 28 days.
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- Ochratoxin A (OTA) is a harmful compound produced by certain fungi, primarily affecting organs like the kidneys and gut.
- The study examined the effects of a 30-day exposure to low doses of OTA in young pigs, looking at their immune responses and oxidative stress levels.
- Findings revealed that even low levels of OTA significantly impacted immune functionality and antioxidant defenses, with more pronounced effects observed in the intestine compared to the kidneys.
Article Synopsis
- Ochratoxin A (OTA), a mycotoxin from fungi like Aspergillus and Penicillium, was tested in a study on its effects on piglets fed a diet contaminated with low levels of OTA (0.05 mg/kg).
- After 30 days, the study found significantly higher levels of OTA in the kidney of poisoned piglets, along with changes in around 105 different genes related to immune response and cellular functions.
- Although OTA did not affect certain kidney functions like urea and creatinine levels, the findings suggest potential early carcinogenic effects and immune response activation that warrant further research regarding implications for human health.
Assessment of the effect of grape seed cake inclusion in the diet of healthy fattening-finishing pigs.
J Anim Physiol Anim Nutr (Berl)
February 2018
Modulatory capacity of bioactive compounds from different wastes has been scarcely investigated in pigs. This study aimed to evaluate the effects of dietary inclusion of grape seed cakes (GS diet) on performance and plasma biochemistry parameters as health indicators, as well as on several markers related to inflammation and antioxidant defence in the liver of fattening-finishing pigs. Twelve cross-bred pigs (TOPIG) were randomly assigned to one of two experimental diets: control and 5% grape seed cake diet during finishing period (24 days).
View Article and Find Full Text PDFReoperative thyroid surgery may be necessary in recurrent simple goiters, thyrotoxicosis and especially cancers of the thyroid gland. The present series reviewed 33 cases representing 7.3 % from our experience consisting of 440 thyroid operations.
View Article and Find Full Text PDF[Bulbantrectomy with truncal vagotomy in the surgical treatment of duodenal ulcer].
Rev Med Chir Soc Med Nat Iasi
May 2005
Duodenal ulcer benefits of very efficient medical treatment. In currently medical practice exist many cases with complicated duodenal ulcer (by stenosis or penetration in neighbor organs like pancreas or biliary tract or painful forms etc.) to which surgical treatment is necessary.
View Article and Find Full Text PDF[CONSIDERATIONS ON 3 CASES OF RADICULO-DENTAL CYSTS OF THE UPPER JAW].
Otorinolaringologie
December 1996