Publications by authors named "Pal Tod"
Article Synopsis
- Tetrabenazine (TBZ) is a medicine that helps with moving too much, but we don't know everything about how it works in the brain.
- In experiments, TBZ was found to stop certain brain chemicals from being stored and released properly, which affects movement and behavior in mice.
- The study also showed that another drug, MDMA, could still make mice more active even when TBZ was affecting the brain's chemical release, helping us understand how these drugs work together.
Purinergic dysfunctions are associated with mania and depression pathogenesis. P2X7 receptor (P2X7R) mediates the IL-1β maturation via NLRP3 inflammasome activation. We tested in a mouse model of the subchronic amphetamine (AMPH)-induced hyperactivity whether P2X7R inhibition alleviated mania-like behavior through IL-1β.
View Article and Find Full Text PDFAs a member of the purinergic receptor family, divalent cation-regulated ionotropic P2X7 (P2rx7) plays a role in the pathophysiology of psychiatric disorders. This study aimed to investigate whether the effects of acute zinc administration and long-term zinc deprivation on depression-like behaviors in mice are mediated by P2X7 receptors. The antidepressant-like effect of elevated zinc level was studied using a single acute intraperitoneal injection in C57BL6/J wild-type and P2rx7 gene-deficient (P2rx7 -/-) young adult and elderly animals in the tail suspension test (TST) and the forced swim test (FST).
View Article and Find Full Text PDFArticle Synopsis
- Extracellular ATP acts as a "danger" molecule through purinergic receptors like P2X7R, impacting neurodevelopmental disorders and neuronal growth.
- P2X7R deficiency or blockade leads to branching deficits in neurons and is linked to schizophrenia-like behaviors in a maternal immune activation model.
- The study uncovers a dual role for P2X7R in neuronal branching during development and highlights its potential pathologic effects in adulthood.
Article Synopsis
- - This study explores the relationship between serum levels of certain molecules involved in purinergic signaling and the activity of schizophrenia in patients, identifying potential biomarkers for diagnosis and treatment.
- - Researchers compared levels of adenine nucleotides and inflammatory markers between 53 patients experiencing acute relapse of schizophrenia and 47 healthy controls, also validating findings in a mouse model of schizophrenia.
- - Results showed elevated serum levels of ATP, ADP, and several interleukins in schizophrenia patients, correlating specific markers with various schizophrenia symptoms, suggesting their use as prognostic tools in the future.
Article Synopsis
- * Treatments during pregnancy, such as NLRP3 antagonist MCC950 and an IL-1β neutralizing antibody, can mitigate the emergence of autistic traits in offspring.
- * The study also identifies a connection between MIA-induced inflammatory markers and the P2X7/NLRP3 pathway, suggesting that targeting these pathways could lead to potential therapies for ASD-related behaviors.
Elderly patients have increased susceptibility to acute kidney injury (AKI). Long noncoding RNAs (lncRNA) are key regulators of cellular processes, and have been implicated in both aging and AKI. Our aim was to study the effects of aging and ischemia-reperfusion injury (IRI) on the renal expression of lncRNAs.
View Article and Find Full Text PDFAcute pancreatitis (AP) is a life-threatening disease. We aimed to explore the prognostic relevance of renal function based on estimated glomerular filtration rate (eGFR). A prospective registry of AP patients was established by the Hungarian Pancreatic Study Group.
View Article and Find Full Text PDF(1) Background: Ischemia reperfusion (IR) is the leading cause of acute kidney injury (AKI) and results in predisposition to chronic kidney disease. We demonstrated that delayed contralateral nephrectomy (Nx) greatly improved the function of the IR-injured kidney and decelerated fibrosis progression. Our aim was to identify microRNAs (miRNA/miR) involved in this process.
View Article and Find Full Text PDFBackground: Organ protection for transplantation is perfusion with ice-cold preservation solutions, although saline is also used in animal experiments and living donor transplantations. However, ice-cold perfusion can contribute to initial graft injury. Our aim was to test if cytoskeletal damage of parenchymal cells is caused by saline itself or by the ice-cold solution.
View Article and Find Full Text PDF: It has been consistently reported that the deficiency of the adenosine triphosphate (ATP) sensitive purinergic receptor P2X7 (P2X7R) ameliorates symptoms in animal models of brain diseases. : This study aimed to investigate the role of P2X7R in rodent models of acute and subchronic schizophrenia based on phencyclidine (PCP) delivery in animals lacking or overexpressing P2X7R, and to identify the underlying mechanisms involved. : The psychotomimetic effects of acute i.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how lipopolysaccharide (LPS)-induced inflammation impacts miRNA expression in the kidneys during septic acute kidney injury (AKI) at different time points.
- Male mice were treated with LPS, and their kidney miRNA profiles were analyzed at 1.5, 6, 24, and 48 hours, revealing significant changes in expression associated with markers of septic AKI.
- Key findings include the identification of miR-762 as a newly elevated miRNA in the early phase and a significant downregulation of its target, Sar1b, alongside the downregulation of aquaporin-1, influenced by other identified miRNAs in the late phase.
Article Synopsis
- * Methods: NMRI mice underwent severe left renal ischemia-reperfusion injury or a sham operation, followed by Nx or sham one week later, with the assessment of several relevant markers for inflammation, oxidative stress, and fibrosis through RT-qPCR techniques.
- * Results: Nephrectomy helped the injured kidneys gradually regain function over 14 to 21 days, reducing inflammation and injury markers significantly, while without Nx, the kidneys showed increased inflammation and became completely fibrotic. This indicates Nx may slow the
(1) Background: Sepsis-induced acute kidney injury (AKI) is the most common form of acute kidney injury (AKI). We studied the temporal profile of the sepsis-induced renal proteome changes. (2) Methods: Male mice were injected intraperitoneally with bacterial lipopolysaccharide (LPS) or saline (control).
View Article and Find Full Text PDFFeeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and mild diastolic dysfunction as published before by Koncsos et al. in 2016. Here we aimed to explore the renal consequences in the same groups of rats.
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