[Conceptual and hypothetical contributions to the pathogenesis of enteritis regionalis (Crohn's disease)].

Crohn's disease (CD) is a multifactorial disorder. The aim of this study was to clarify the pathogenesis of CD by analyzing the clinical data of patients treated at our institute in the last ten years. The authors observed several clinical, pathological and submicroscopic features of Crohn's disease which are characteristic of Selye's concept of stress.

Electron microscopic characteristics of beta2-microglobulin amyloid deposits in long-term haemodialysis.

The electron microscopic features of beta2-microglobulin amyloid, deposited in the synovial membrane, are presented and discussed. The patient, a 69-year-old woman underwent chronic hemodialysis for 3 years. Because of constant pain and destructive arthropathy, endoprosthesis of the hip joints were implanted.

[Ultrastructural findings in the liver due to long-term retinol (isotretinoin) treatment. Significance of the perisinusoidal (Ito) cells].

A twenty year old, foreign-born sportsman visited the Out-patient Clinic of our Hospital with complaints of progressive arthralgia, hepatomegaly and increasingly abnormal liver function tests of six months duration. Tests for virus hepatitis were negative, alcohol abuse or drug addiction could be excluded. An open needle biopsy of the liver was performed and the tissue was examined with the light and electron microscope.

Ultrastructural identification of primary tumor site from bone metastases.

The value of electron microscopy is demonstrated by ultrastructural identification of primary tumor site from bone metastases in 2 patients.