pH-Responsive Water-Soluble Chitosan Amphiphilic Core-Shell Nanoparticles: Radiation-Assisted Green Synthesis and Drug-Controlled Release Studies.

This work aims to apply water radiolysis-mediated green synthesis of amphiphilic core-shell water-soluble chitosan nanoparticles (WCS NPs) via free radical graft copolymerization in an aqueous solution using irradiation. Robust grafting poly(ethylene glycol) monomethacrylate (PEGMA) comb-like brushes were established onto WCS NPs modified with hydrophobic deoxycholic acid (DC) using two aqueous solution systems, i.e.

Biosensors for the detection of organophosphate exposure by a new diethyl thiophosphate-specific aptamer.

Objective: An aptamer specifically binding to diethyl thiophosphate (DETP) was constructed and incorporated in an optical sensor and electrochemical techniques to enable the specific measurement of DETP as a metabolite and a biomarker of organophosphate exposure.

Results: A DETP-bound aptamer was selected from the library using capillary electrophoresis-systematic evolution of ligands by exponential enrichment (CE-SELEX). A colorimetric method revealed that the aptamer had the highest affinity for DETP, with a mean K value (± SD) of 0.