Publications by authors named "Pakize Ak"
Article Synopsis
- Gain-of-function mutations in SHP2 are commonly found in sporadic juvenile myelomonocytic leukemia (JMML) and myeloproliferative neoplasms (MPN) associated with Noonan syndrome (NS).
- Researchers studied the gene expression of hematopoietic stem and progenitor cells (HSPCs) with SHP2 mutations from JMML patients and a new zebrafish model, finding an inflammatory gene pattern.
- Treatment with an anti-inflammatory agent improved the JMML-like MPN in zebrafish embryos, suggesting inflammation in HSPCs might be a potential therapeutic target for JMML.
