[Pathogenetic significance of the immediate and delayed types of hypersensitivity reactions in the dynamics of nephritis].

Complex study of the immunologic status of rats from the first days after the injection of nephrotoxic serum up to formation of chronic renal failure in comparison with functional and morphological characteristics of the disease confirmed the hypothesis on the phasic development and different pathogenetic role of the hypersensitivity reactions of the immediate and delayed types during nephritis. Signs of the immediate hypersensitivity predominated during the initial stages of the disease; realization of this hypersensitivity is indicated both by the liberation of the mediators of the pathochemical phase and by the change of the renal processes. The development of delayed hypersensitivity reactions plays the basic role in the pathogenesis of chronic nephritis.