Publications by authors named "Pak T Chan"
Background: Endoscopic submucosal dissection (ESD) has gained increasing popularity in the management of complicated colorectal polyps. However, clinical outcomes for ESD have remained highly inconsistent worldwide. This study investigated and analysed factors that significantly affect ESD outcomes.
View Article and Find Full Text PDFBackground: Endoscopic submucosal dissection (ESD) enables removal of broad-based colorectal polyps or lateral spreading tumors with a higher rate of en bloc resection and a lower risk of local recurrence. However, it is technically demanding. Over the past 20 years, various equipment and innovative techniques have been developed to reduce the difficulty of ESD.
View Article and Find Full Text PDFWe have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed that GSK3A and RHOA were differential expressed genes identified by a cut-off of fold change >2 and adjusted P value < 0.
View Article and Find Full Text PDFCase-Matched Analysis Comparing Endoscopic Submucosal Dissection and Surgical Removal of Difficult Colorectal Polyps.
J Laparoendosc Adv Surg Tech A
October 2018
Introduction: It is not uncommon to encounter colorectal polyps which could not be removed easily by simple polypectomy. Endoscopic submucosal dissection (ESD) has been a well-established method for doing so. We compared the result between ESD and surgical removal of these difficult colorectal polyps.
View Article and Find Full Text PDFPrognostic significance of Cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patients.
Oncotarget
January 2018
Background: Cytokeratin 20-positive cells in lymph nodes from pN0 colorectal cancer (CRC) patients were detected previously by us. The aims of this study were to investigate which tumor metastasis-related genes were involved and their potential clinical significance.
Results: Fourteen of 84 (17%) genes were differentially expressed by at least 2-fold.
Article Synopsis
- The study examines the prevalence of antiphospholipid syndrome (APS) and its effects on survival among Chinese patients with systemic lupus erythematosus (SLE), finding that 6.5% of the 679 patients met the criteria for APS.
- Among those with APS, 20% died during the study period, which was higher than the 9% death rate in patients without APS, indicating increased mortality risk associated with APS, especially due to arterial thrombosis.
- Although overall mortality for APS patients was not significantly higher than for non-APS patients, those whose APS was linked to arterial thrombosis had a notably greater risk of death.
Article Synopsis
- The study aimed to examine how common low bone mineral density (BMD) is in patients with systemic sclerosis (SSc) and identify potential risk factors.
- A total of 84 SSc patients were compared to an equal number of healthy individuals, finding that SSc patients had significantly lower BMD, fat mass, and lean body mass.
- Key risk factors for low BMD in SSc patients included higher age, menopause status, and low BMI, while the severity of skin and other systemic involvement did not affect BMD levels.
Prevalence of atherosclerotic risk factors and the metabolic syndrome in patients with chronic inflammatory arthritis.
Arthritis Care Res (Hoboken)
February 2011
Article Synopsis
- The study aimed to assess how common metabolic syndrome is among patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA).
- A total of 930 patients were analyzed, with results indicating that metabolic syndrome was most prevalent in PsA patients (38%), significantly higher than in RA (20%) and AS (11%).
- The findings suggest that PsA patients have elevated rates of specific risk factors like impaired fasting glucose and central obesity, highlighting a serious health risk compared to those with RA or AS.