Publications by authors named "Paik K"

Data on pregnancy outcomes in patients with alopecia areata (AA) are limited. The aim of this study is to determine the association between maternal AA and risk of adverse birth outcomes in children. A retrospective cohort study was conducted on 45,328 children born to mothers with AA and 4,703,253 controls born to mothers without AA using the Korean National Health Insurance Claims database from 2002 to 2016.

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Bullous pemphigoid (BP) is the most prevalent autoimmune blistering disorder, triggered by autoantibodies targeting hemidesmosome components. It is associated with substantial morbidity and increased mortality. No studies comprehensively evaluate all comorbidities before and after diagnosing patients with BP.

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Due to the swift advancement of the electronic industry and information technology, electromagnetic wave absorption materials are gaining significance in the field of intelligent equipment and weaponry. Nanomaterials were developed to investigate wave absorbing materials that can achieve both impedance matching and attenuation balance. Nanomaterials possess the properties of being thin, lightweight, and capable of absorbing microwave radiation across a wide range of frequencies.

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Background: The purpose of this study was to determine whether the application of the Endo GIA Stapler (Medtronic, Dublin, Ireland) could be helpful in the dissection of adrenal tumors in complicated cases.

Methods: We retrospectively reviewed the records of patients who underwent laparoscopic adrenalectomy between 2012 and 2022 at the College of Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea (Seoul, Republic of Korea).

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Particulate matter (PM) is a harmful air pollutant composed of chemicals and metals which affects human health by penetrating both the respiratory system and skin, causing oxidative stress and inflammation. This review investigates the association between PM and skin disease, focusing on the underlying molecular mechanisms and specific disease pathways involved. Studies have shown that PM exposure is positively associated with skin diseases such as atopic dermatitis, psoriasis, acne, and skin aging.

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Catheter-based embolization has become a widely adopted minimally-invasive treatment for a broad range of applications. However, assessment of embolization endpoints requires x-ray fluoroscopic monitoring, exposing patients and physicians performing embolization procedures to harmful ionizing radiation. Moreover, x-ray fluoroscopy assessment of embolization endpoints is low sensitivity, subjective, and may not reflect the actual physiology of blood flow reduction, thus providing little oversight of the embolization procedure.

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Introduction: A subset of children with Chiari 1 malformation (CM-1) have a 4th ventricle arachnoid veil-a thin membrane covering the outlet of the 4th ventricle. Studies suggest that failure to disrupt this veil during posterior fossa decompression can reduce the likelihood of syringomyelia resolution. However, there is no reliable method for predicting the presence of the veil without direct surgical exploration.

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Article Synopsis
  • - Nail psoriasis is a long-lasting condition impacting the nails, assessed through the Nail Psoriasis Severity Index (NAPSI), but the evaluation can be time-intensive in real-life clinical situations.
  • - To streamline this process, researchers developed a deep learning algorithm (DLA) trained on a dataset of 7,054 fingernail images, which reliably evaluates NAPSI by analyzing annotated nail features.
  • - The DLA demonstrated strong performance, with only a 2-point difference from the actual NAPSI in 98.6% of cases, achieving good accuracy and promising utility for both clinical and research applications.
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Background: The modified Nutrition Risk in the Critically Ill (mNUTRIC) score was developed to identify patients most likely to benefit from nutritional therapies and to stratify or select subjects for clinical trials. However, the validity of the score and the association between that score and the prognosis of patients in surgical intensive care units (SICUs) remain unclear. This study explored whether the score was a useful prognostic indicator for SICU patients, and whether survival could be improved via nutritional interventions based on mNUTRIC status.

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Article Synopsis
  • - The study analyzed 676 patients with acute pancreatitis (AP) from 12 medical centers in Korea, finding that 57.4% were male with an average age of 58.6 years; mild AP was most common, while severe AP had a high mortality rate of 45%.
  • - The leading causes of AP were biliary problems (41.6%) and alcohol use (24.6%), with a notable 16.4% of cases having an unidentified etiology at admission; treatment gaps were evident, particularly in fluid management for severe cases.
  • - The findings indicate significant discrepancies between recommended clinical guidelines for managing AP and their actual implementation, highlighting the need for improved adherence to best practices to reduce recurrence
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Scalp-related symptoms such as dandruff and itching are common with diverse underlying etiologies. We previously proposed a novel classification and scoring system for scalp conditions, called the scalp photographic index (SPI); it grades five scalp features using trichoscopic images with good reliability. However, it requires trained evaluators.

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Article Synopsis
  • - This study focuses on allergic diseases like atopic dermatitis and allergic rhinitis, highlighting their complex nature which involves both genetics and environment in the Korean population.
  • - A genome-wide association study (GWAS) analyzed 8,823 samples and identified three significant single nucleotide polymorphisms (SNPs) linked to allergic diseases, located on specific chromosomes.
  • - The findings suggest these SNPs could provide insights into the genetic factors of allergic diseases, but further research is needed to confirm their relevance in different populations.
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Background: Periampullary cancer (PAC) is highly aggressive with no effective adjuvant therapy or prognostic markers. Recently, poly (ADP-ribose) polymerase-1 (PARP-1) has emerged as a target in solid cancers, and its relationship with epithelial-mesenchymal transition (EMT) has been observed. However, the relationship between PARP-1 and EMT in PAC has not explored well.

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Background: Little is known about the characteristics of early pancreatic cancer. We aimed to identify the characteristics, clues for early detection, and prognostic factors for early pancreatic cancer by analyzing a large number of patients with stage 1 pancreatic cancer.

Methods: A clinical data warehouse that includes databases of all the medical records of eight academic institutions was used to select and analyze patients with pancreatic cancer that had been diagnosed from January 2010 to May 2023.

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Introduction: The agreement between the radiologic and histopathologic tumor locations in T2 gallbladder cancer is critical. There is no consensus regarding the extent of curative resection by tumor locations.

Methods: Between January 2010 and December 2019, a consecutive series of 118 patients with pathological T2 gallbladder cancer who underwent surgery were retrospectively analyzed in terms of the accordance between radiologic and histopathologic tumor locations, the extents of hepatic resection and the numbers of harvested lymph nodes.

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Background: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder. Unique ASD subtypes have been proposed based on specific genotype-phenotype combinations. The ASD subtype associated with various chromodomain helicase DNA-binding protein 8 (CHD8) mutations has been associated with an incidence of autistic regression greater than that of all-cause ASD, but the mean age of onset of this subtype remains unknown.

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Article Synopsis
  • The increasing prevalence of neurocognitive disorders (NCDs), such as mild cognitive impairment and dementia, highlights the urgent need for global prevention strategies.
  • An umbrella review synthesized findings from 45 reviews and 212 meta-analyses, identifying 14 modifiable risk factors linked to NCDs, including alcohol consumption, depression, and physical inactivity.
  • The study emphasizes the need for targeted prevention efforts that address these risk factors to reduce the incidence and severity of NCDs, particularly noting gaps in research related to vascular dementia and mild NCD.
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Patients with psoriasis frequently have comorbidities, which are linked to higher mortality rates. An in-depth investigation of comorbidities and their effects on health can help improve the management of patients with psoriasis. We conducted a comprehensive and unbiased investigation of comorbidities in patients with psoriasis and explored the pattern of association between comorbidities.

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Artificial intelligence (AI) and machine learning (ML) have an immense potential to transform healthcare as already demonstrated in various medical specialties. This scoping review focuses on the factors that influence health data poverty, by conducting a literature review, analysis, and appraisal of results. Health data poverty is often an unseen factor which leads to perpetuating or exacerbating health disparities.

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Background: Noncommunicable disease (NCD) prevention and control in humanitarian emergencies is a well-recognized need, but there is little evidence to guide responses, leading to varying care delivery. The Sana.NCD mobile health (mHealth) app, initially developed in Lebanon, is the only known mHealth tool for NCD management designed to increase care quality and coverage for providers in humanitarian settings.

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The effect of antipsoriatic therapy on cardio-cerebrovascular disease (CCVD) is not well described. Thus, we performed a population-based nested case-control study to investigate the effect of systemic antipsoriatic therapy on CCVD in psoriasis patients. Using nationwide cohort data from the Korean National Health Insurance Claims database, newly diagnosed psoriasis patients were identified.

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Purpose: Previous gastrectomy (PG) can lead to an increased incidence of biliary stones. However, the success rate of endoscopic retrograde cholangiopancreatography after gastrectomy remains low. In such cases, laparoscopic common bile duct exploration (LCBDE) may be an alternative.

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Palmoplantar pustulosis (PPP) is a variant of pustular psoriasis involving the palms and soles. The severity of PPP is usually evaluated using the Palmoplantar Pustulosis Area and Severity Index (PPPASI). Among the components of the PPPASI, the area of the involved lesion is evaluated differently by raters, who generally make a rough estimate using the eye and not through a specific calculation.

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