Publications by authors named "Paige M Brooks"
In the zebrafish lateral line, non-sensory supporting cells readily re-enter the cell cycle to generate new hair cells and supporting cells during homeostatic maintenance and following damage to hair cells. This contrasts with supporting cells from mammalian vestibular and auditory sensory epithelia which rarely re-enter the cell cycle, and hence loss of hair cells results in permanent sensory deficit. Lateral line supporting cells are derived from multipotent progenitor cells that migrate down the trunk midline as a primordium and are deposited to differentiate into a neuromast.
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- Genetic variability plays a crucial role in differences in skeletal muscle mass, but the specific genes responsible are not well understood; this study focuses on Rps6ka6 and Pou3f4 genes located on chromosome X in mice.
- The study involved analyzing muscle samples from male CFW mice with different alleles linked to muscle mass, revealing that the "increasing" allele led to larger muscle size and more muscle fibers, particularly in the fast-twitch extensor digitorum longus muscle.
- Findings suggest that Rps6ka6 influences muscle fiber count in fast-twitch muscles, whereas the Pou3f4 gene impacts fiber numbers in slow-twitch muscles, indicating distinct genetic roles in muscle development.
During inner ear development, primary auditory neurons named spiral ganglion neurons (SGNs) are surrounded by otic mesenchyme cells, which express the transcription factor Pou3f4. Mutations in Pou3f4 are associated with DFNX2, the most common form of X-linked deafness and typically include developmental malformations of the middle ear and inner ear. It is known that interactions between Pou3f4-expressing mesenchyme cells and SGNs are important for proper axon bundling during development.
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