is regulated by salinity, prolactin and extracellular osmolality in tilapia gill.

Teleosts inhabiting fresh water (FW) depend upon ion-absorptive ionocytes to counteract diffusive ion losses to the external environment. A Clc Cl channel family member, Clc-2c, was identified as a conduit for basolateral Cl transport by Na/Cl cotransporter 2 (Ncc2)-expressing ionocytes in stenohaline zebrafish (). It is unresolved whether Clc-2c/ is expressed in euryhaline species and how extrinsic and/or intrinsic factors modulate branchial mRNA.