Publications by authors named "Paige H Steffen"
Article Synopsis
- Puberty marks a key transition to reproductive capability and is driven by the activation of gonadotropin-releasing hormone (GnRH) neurons, with kisspeptin neurons likely playing a role in this activation.
- Researchers selectively removed arcuate kisspeptin neurons (KNDy neurons) in juvenile mice to study their influence on the timing of puberty, finding that their absence led to delayed puberty and lower hormone levels.
- The study concluded that while most KNDy neurons are critical for the timing of puberty onset, a smaller subset is sufficient for normal GnRH pulse timing, and full KNDy neuron functionality is not necessary for generating the LH surge in females.
