Publications by authors named "Paige E Pistono"
Virus-like particles (VLPs) from bacteriophage MS2 provide a platform to study protein self-assembly and create engineered systems for drug delivery. Here, we aim to understand the impact of intersubunit interface mutations on the local and global structure and function of MS2-based VLPs. In previous work, our lab identified locally supercharged double mutants [T71K/G73R] that concentrate positive charge at capsid pores, enhancing uptake into mammalian cells.
View Article and Find Full Text PDFProtein-based nanoparticles are useful models for the study of self-assembly and attractive candidates for drug delivery. Virus-like particles (VLPs) are especially promising platforms for expanding the repertoire of therapeutics that can be delivered effectively as they can deliver many copies of a molecule per particle for each delivery event. However, their use is often limited due to poor uptake of VLPs into mammalian cells.
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- - Calcium plays a crucial role in the early stages of wound healing, but the process by which it facilitates regeneration is not fully understood.
- - A mutation in a zebrafish gene called padi2 eliminates calcium-dependent citrullination, leading to issues with inflammation resolution and regeneration after injury.
- - Padi2 is essential for modifying histones in specific cells during tissue repair, linking early calcium signaling to the necessary cell growth for effective regeneration.