Assessing structural and functional response of murine vasculature to acute β-adrenergic stimulation during hypothermic and hyperthermic conditions.

Because of the importance of adrenoreceptors in regulating the cardiovascular (CV) system and the role of the CV system in thermoregulation, understanding the response to these two stressors is of interest. The purpose of this study was to assess changes of arterial geometry and function during thermal and β-adrenergic stress induced in mice and quantified by MRI. Male mice were anesthetized and imaged at 7 T.

Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion.

Background: One of the primary biomechanical factors influencing arterial health is their deformation across the cardiac cycle, or cyclic strain, which is often associated with arterial stiffness. Deleterious changes in the cardiovascular system, e.g.