Publications by authors named "Paige A Rist"
Article Synopsis
- Researchers explored how adding sulfur to propargylic carboxylates affects gold-catalyzed reactions involving alkynes.
- These reactions lead to the creation of functionalized indole products under mild conditions using a regiodivergent approach.
- Selective carboxylate migrations (both 1,2 and 1,3) were achieved, with indole attaching in a 1,4 position relative to the sulfenyl group, influenced by factors like the catalyst system and counterion.
C3-selective C-C bond formation on benzothiophenes is challenging, and few direct functionalization methods are available. A gold-catalyzed reaction of alkynes with benzothiophene -oxides provides regioselective entry into C3-alkylated benzothiophenes with the C7-alkylated isomer as the minor product. This oxyarylation reaction works with alkyl and aryl alkynes and substituted and unsubstituted benzothiophenes.
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