Publications by authors named "Pai V"
Aim: To compare the microleakage in class V cavities restored with Activa Bioactive Restorative, Activa Pronto, and nanohybrid composite.
Materials And Methods: Standardized class V cavity preparations (mesiodistal: 3 mm; occlusocervical: 2 mm; axial depth: 1 mm) were made on the buccal surface of 60 extracted intact maxillary premolar teeth. The preparations were divided into three experimental groups ( = 20) depending on the restorative material used.
Purpose: Currently, no standard for the measurement of retinal oxygen extraction exists. Here, we present a novel approach for measurement of retinal oxygen extraction based on two commercially available devices, namely laser speckle flowgraphy (LSFG) and retinal oximetry.
Methods: The study was conducted in a randomized, double-masked design.
Background: Calcific metamorphosis in root canals is common and presents challenges in gaining access. Guided endodontics offers a solution to overcome these difficulties. The PriciGuide® system is a patented guided endodontic technique claiming superior precision compared to sleeve-based guides.
View Article and Find Full Text PDFA fundamental goal of evaluating the performance of a clinical model is to ensure it performs well across a diverse intended patient population. A primary challenge is that the data used in model development and testing often consist of many overlapping, heterogeneous patient subgroups that may not be explicitly defined or labeled. While a model's average performance on a dataset may be high, the model can have significantly lower performance for certain subgroups, which may be hard to detect.
View Article and Find Full Text PDFBackground: The diagnosis of leptomeningeal metastatic disease has major prognostic and therapeutic implications. We report 13 patients with a radiologically distinct kind of focal, enhancing leptomeningeal lesion on brain MRI that mimics leptomeningeal metastatic disease.
Methods: These patients were assessed at University Health Network (Toronto, Canada) between January 2001 and December 2023.
Background: Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs). Most functional microproteins were chosen for characterization because of their evolutionary conservation. However, one example of a non-conserved immunomodulatory microprotein in mice suggests that strict sequence conservation misses some intriguing microproteins.
View Article and Find Full Text PDFCaloric restriction mimetics mimic the beneficial effects of dietary restriction approaches, such as caloric restriction approaches, without limiting the dietary intake. Chlorogenic acid (CGA) acts as a caloric restriction mimetic; however, its neuroprotective mechanisms remain ambiguous. Therefore, in this study, we aimed to elucidate the neuroprotective effects of CGA on SH-SY5Y cells treated with amyloid-beta (Aβ)1-42.
View Article and Find Full Text PDFArticle Synopsis
- - Traumatic injuries to anterior teeth can cause issues like calcification and periapical lesions, often requiring root canal treatment, but traditional preparation methods may weaken the tooth structure.
- - The AReneto® system, created by Roots to Cusps® Private Limited, employs augmented reality to assist clinicians in performing more precise, minimally invasive endodontic procedures.
- - A case study of a 24-year-old male with traumatic dental injuries demonstrates the efficacy of the AReneto® system for root canal treatment, leading to improved patient outcomes and better preservation of tooth integrity.
Special Considerations for Cross-Sectional Imaging in the Child with Neurovascular Disease.
Neuroimaging Clin N Am
November 2024
Article Synopsis
- Pediatric neurovascular diseases are serious conditions that can lead to significant health problems and even death.
- These diseases show a wide range of symptoms, from urgent neurological issues to long-term cognitive and developmental challenges, making accurate diagnosis important.
- The article reviews the imaging techniques used to diagnose these diseases and highlights common findings observed in pediatric patients.
Diffusion tensor imaging of vastus lateralis in patients with inflammatory myopathies.
Rheumatology (Oxford)
October 2024
Article Synopsis
- The study aimed to explore how diffusion tensor imaging (DTI) could detect inflammation in the vastus lateralis muscle of patients with myositis and correlate it with histopathological findings.
- It involved 43 patients, with MRI scans and muscle biopsies taken to analyze muscle edema and fatty infiltration, comparing imaging data to histopathological results.
- Findings showed that while certain MRI parameters indicated muscle inflammation, adding DTI or DWI did not significantly improve the detection of active inflammation in myositis cases.*
Article Synopsis
- The study focuses on evaluating the heterogeneous treatment effect (HTE) of benzene exposure on childhood acute myeloid leukemia (AML) using three machine learning algorithms: causal random forest (CRF), causal Bayesian additive regression trees (CBART), and causal rule ensemble (CRE).
- All three algorithms showed minimal differences in their predicted average treatment effects and regression coefficients, but CRF was more efficient in computational time and capable of handling both continuous and binary treatment variables.
- The research also explores the effects of adding noise and outliers in data analysis with CRF and provides guidelines for researchers on using these algorithms for environmental health studies and pollutant exposure assessments.
Traumatic injuries to maxillary central incisors often necessitate root canal treatment (RCT). However, traditional access cavity preparation can remove significant dentin, compromising tooth strength and long-term prognosis. This article explores the use of the PriciGuide™ system for minimally invasive access cavity preparation in such cases.
View Article and Find Full Text PDFArticle Synopsis
- The prevalence of nerve tissue injuries and neurodegenerative diseases is rising due to factors like stress and an aging population, making restoration efforts difficult.
- Current treatments mainly provide symptom relief, with no cure available, while stem cells show promise but face limitations in survival and regeneration.
- Neural tissue engineering is emerging as a solution, utilizing biomaterials to enhance stem cell viability and mimic natural tissue properties for improved recovery and treatment of neurological disorders.
Article Synopsis
- * It can be triggered by various factors, including infections or cancers, and shares imaging features with other types of encephalitis, particularly limbic encephalitis.
- * Increased awareness and understanding of AE have improved its detection, highlighting the importance of recognizing its signs in MRI reports for better treatment outcomes.
Purpose: BIOEMBRACE was designed to study the impact of biomarkers in addition to clinicopathological factors on disease outcomes in patients treated with chemoradiation and magnetic resonance imaging (MRI)-guided brachytherapy (BT) for locally advanced cervical cancer in the EMBRACE study.
Methods And Materials: Between 2018 and 2021, 8 EMBRACE-I sites contributed tumor tissue for the immunohistochemistry of p16, PD-L1, and L1CAM. These biomarkers and clinicopathological factors (International Federation of Gynecology and Obstetrics 2009 stage, nodal status, histology, and necrosis on MRI) were analyzed to predict poor response at BT (high-risk clinical target volume [HR-CTV] ≥ 40 cc) at BT) and 5-year local control, pelvic control, and disease-free survival.
Glioneuronal tumors (GNTs) are an expanding group of primary CNS neoplasms, commonly affecting children, adolescents and young adults. Most GNTs are relatively indolent, low-grade, WHO grade I lesions. In the pediatric age group, GNTs have their epicenter in the cerebral cortex and present with seizures.
View Article and Find Full Text PDFObjective: To examine resource and service use after discharge among infants born extraordinarily preterm in California who attended high-risk infant follow-up (HRIF) clinic by 12 months corrected age.
Study Design: We included infants born 2010-2017 between 22 + 0/7 and 25 + 6/7 weeks' gestational age in the California Perinatal Quality Care Collaborative and California Perinatal Quality Care Collaborative-California Children's Services HRIF databases. We evaluated rates of hospitalization, surgeries, medications, equipment, medical service and special service use, and referrals.