Publications by authors named "Pagonis K"

Inflatable penile prosthesis (IPP) surgery is an effective treatment for erectile dysfunction (ED), but infections pose a significant threat to its success. Current guidelines lack antifungal recommendations, despite rising fungal infection rates post-IPP surgery. This review examines epidemiology, risk factors (including diabetes mellitus, immunosuppression, and obesity), and pathogenesis, highlighting the role of biofilm formation in device contamination.

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Article Synopsis
  • The study aimed to assess the effectiveness and safety of using high-power Holmium: Yttrium-Aluminum-Garnet (Ho:YAG) lasers over 100 W for bladder stone treatment.
  • An experimental setup involved testing on artificial stones and porcine bladder, while a clinical trial was conducted on 35 patients with various laser power settings.
  • Results showed a 100% stone-free rate in patients, faster ablation rates with high power, and minimal complications, indicating that Ho:YAG laser lithotripsy is a safe and efficient method for treating bladder stones.
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Objective: In this review, we investigated the current literature to find out which artificial stones (AS) are available in endourology, and in which experimental and training schemes they are used.

Materials And Methods: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Twenty-one out of 346 studies met our inclusion criteria and are presented in the current review.

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Purpose: The aim of this study is the evaluation of the distribution of paclitaxel (PTX) released by a coated balloon in the layers of rabbit's urethra.

Methods: 18 rabbits were included. A laser device was used for the stricture formation.

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Objective: Transurethral resection of bladder tumor is one of the most common everyday urological procedures. This kind of surgery demands a set of skills that need training and experience. In this review, we aimed to investigate the current literature to find out if simulators, phantoms, and other training models could be used as a tool for teaching urologists.

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Objective: To evaluate the feasibility and the safety of medial non-papillary percutaneous nephrolithotomy (npPCNL) for the management of large proximal ureteral stones.

Methods: We evaluated prospectively collected data of 37 patients with large proximal ureteral stones more than 1.5 cm in diameter treated by prone npPCNL.

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Article Synopsis
  • Peyronie's disease (PD) causes abnormal penile curvature, and there is ongoing debate about the best surgical graft material for its correction.
  • A review of existing studies found that buccal mucosa grafts (BMG) provide the highest rates of penile straightening and the least erectile dysfunction post-surgery, while TachoSil grafts were effective despite higher initial curvature.
  • Overall, while BMG is generally the most effective for low curvature, the TachoSil graft performs best when considering preoperative curvature, highlighting the need for more comparative clinical trials.
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  • The study aimed to assess the learning curve for four basic surgical skills in both laparoscopic and robotic surgeries using the avatera® system.
  • Participants, who had no prior experience, practiced tasks after watching educational materials and undergoing 2-hour training, with their performance times measured across multiple attempts.
  • Results showed that practice significantly reduced completion times, and prior laparoscopic experience enhanced training efficiency, indicating that robotic skills can be learned more quickly than laparoscopic ones.
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Introduction: The aim of this study was to evaluate outflow variation in different locations of the pyelocaliceal system with the use of different ureteral access sheath (UAS) sizes and different UAS positioning.

Material And Methods: The experimental setup included an anaesthetised porcine model, a 7.5-Fr ureteroscope with a 200-μm laser fibre inserted in the working channel, a hand-held pumping irrigating system, and UAS of different sizes, namely: 9.

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Objective: To evaluate the tissue injury caused by the force applied by the roboticassisted graspers of avatera robotic surgical system on bowel tissue.

Methods: An experimental in vivo porcine model with 1 pig was conducted. After a standard transperitoneal setup of the avatera robotic surgical system, different laparoscopic and robotic graspers were used on the bowel with maximum force applied each time.

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Bladder malignancy represents the fourth most common cancer in men and the eighth in women in the western world. Women under 75 years of age have a risk of 0.5-1% of developing bladder cancer.

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Objective: To evaluate the transfer of the practical skills of robot-assisted surgery acquired in the dry-lab into a real live experimental setting for performing upper and lower urinary tract surgeries.

Material And Methods: An in vivo experimental study design was utilized. Six urology trainees and fellows; two 2nd year trainees with no previous exposure to laparoscopic surgery (Group 1), two 4th year residents with medium exposure to laparoscopic surgery (Group 2) and two fellows trained to perform laparoscopic surgeries (Group 3) performed ureteral reimplantation into the bladder, pyeloplasty, and radical nephrectomy on three female pigs under general anesthesia.

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Purpose: To compare the perioperative and postoperative outcomes between Oyster prostate vaporesection using Tm-YAG laser and the conventional transurethral prostatectomy using monopolar energy.

Methods: Patients with LUTS with an accumulative size of at least 60 ml were randomly assigned to one of two parallel groups to undergo Tm-YAG laser vaporesection (Group 1) or conventional monopolar transurethral prostatectomy (Group 2). The primary endpoints were the reduction in IPSS and the increase in Qmax postoperatively.

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Introduction: The high-power holmium: yttrium-aluminum-garnet lasers provide a wide variety of settings for stone disintegration. The aim of this study is to evaluate the effect of short and long pulse duration on ablation rates on urinary stones.

Materials And Methods: Two types of artificial stones were created by BegoStone™ with different compositions (15:3 and 15:6, stone/water ratio).

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Purpose: The purpose of this study was to evaluate renal parenchymal trauma of two-step dilation compared to the conventional Amplatz gradual dilation during percutaneous nephrolithotomy on a porcine model.

Materials And Methods: A nonpapillary percutaneous access tract was established under fluoroscopic guidance in both kidneys of four female pigs. On the right kidney of each pig, gradual dilation was performed using an Amplatz dilator set with a gradual dilation to 30 Fr, whereas on the left, a two-step dilation was utilized using only 16 Fr and 30 Fr dilators.

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Introduction: The aim of this study was to evaluate the possible histopathological alterations that occur in the kidneys due to a continuous temperature increase above 43°C for one hour of lithotripsy using a newly introduced thulium fiber laser (TFL).

Material And Methods: Two female pigs were used. After the insertion of a 9.

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Purpose: To investigate the feasibility of the avatera system for performing robot-assisted radical cystectomy (RARC) followed by intracorporeal reconstruction of ileal neobladder.

Methods: Six anesthetized female pigs were used to perform RARC and formation of the intracorporeal orthotopic ileal neobladder. Three surgeons with different level of expertise in the use of robotic systems performed RARC after a short instructional lecture and a 2-h hands-on training.

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Article Synopsis
  • The study assessed the effectiveness and safety of non-papillary prone percutaneous nephrolithotomy (PCNL) for patients with various renal abnormalities, focusing on those with stones larger than 1.5 cm.
  • A total of 57 patients with different kidney conditions, such as horseshoe and malrotated kidneys, were treated, showing an 84.2% stone-free rate and an average hospital stay of about 2.7 days.
  • Results suggest that non-papillary punctures are a safe alternative to the traditional approach, challenging the belief that only papillary punctures are safe for treating large stones in malformed kidneys.
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To evaluate the feasibility and intraoperative technical parameters of the new robot-assisted surgical system Avatera by performing bilateral nephrectomy in a live porcine model. Six pigs underwent bilateral robot-assisted radical nephrectomy using the Avatera robotic system (RS). The operations were performed by experienced open (Group 1) and laparoscopic (Group 2) surgeons.

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Purpose: To evaluate the effectiveness and safety of nonpapillary prone endoscopic combined intrarenal surgery (ECIRS) and provide practical tips and tricks for the successful accomplishment of the procedure respecting the anatomical particularities.

Material And Methods: This study is an analysis of a prospectively collected database including all cases of ECIRS performed between January 2019 and December 2021 in a high-volume tertiary center. All patients underwent the procedure in prone-split leg position.

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Objective: To investigate the effect of the diameter of laser fiber, pelvis volume, presence and type of the stone on irrigation fluid temperature rise.

Material And Methods: A 20ml syringe, 12/14 ureteral access sheath(UAS), a dual-lumen catheter and a thermocouple were used.  The 12/14Fr UAS(Cook Ireland Ltd.

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Objective: To evaluate the feasibility and success of medial non-papillary percutaneous access for the antegrade treatment of different locations of ureteral stones, with and without concomitant renal stones.

Methods: We performed an analysis of prospectively collected data of 72 patients, being subjected to percutaneous antegrade ureterolithotripsy. Stones located anywhere in the ureter with or without concomitant renal stones were included.

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To evaluate the clearance of metal particles produced and released in the pelvicaliceal system (PCS) during percutaneous nephrolithotomy (PCNL) with the use of the Swiss Lithoclast Trilogy dual-energy (EMS Urology, Nyon, Switzerland) lithotripter. An experimental study and a clinical investigation of case series were conducted. An porcine model with two pigs for lithotripsy (after inserting artificial stones into the collecting system) and two pigs for submucosal injection of metal particles (provided by the manufacturer of Trilogy) was conducted.

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Purpose: Based on the current trend of miniaturization of instruments used in percutaneous nephrolithotomy (PCNL), it is necessary to compare different PCNL modalities regarding their access sheath size used. Thus, the safety and efficacy among standard, mini and ultra-mini PCNL (s-PCNL, m-PCNL, um-PCNL) were compared.

Methods: We performed a prospective, non-randomized trial between January 2018 and July 2020.

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To compare the effect of MOSES™ modulation technology to conventional pulse delivery technology on the irrigation fluid temperature (IFT) under different irrigation conditions during flexible ureteroscopy (FURS) in a live-anesthetized porcine model. For this experiment was used one female pig. A percutaneous access was obtained and a 30Fr sheath was placed inside the upper calyceal system.

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