Publications by authors named "Page A Brown"
Article Synopsis
- A study investigated how four different endoglucanases interact with amorphous cellulose films using neutron reflectometry (NR) and quartz crystal microbalance with dissipation monitoring (QCM-D).
- The endoglucanases examined included two from fungi and two from thermophilic bacteria, highlighting the potential of ionic liquid pretreatment in disrupting cellulose's crystalline structure.
- Results showed that the presence of carbohydrate-binding modules (CBMs) in Cel45A and Cel5H allowed them to penetrate and digest the cellulose films more effectively than Cel9A and Cel5A, which lack CBMs, indicating varied mechanisms of action among the enzymes.
Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine. To realize this potential, however, targeted nanocarriers must simultaneously overcome multiple challenges, including specificity, stability and a high capacity for disparate cargos. Here we report porous nanoparticle-supported lipid bilayers (protocells) that synergistically combine properties of liposomes and nanoporous particles.
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