We're in This Together: A Case Study of the Concurrent Delivery of Prolonged Exposure Therapy to Intimate Partners With PTSD.

Research on the links between intimate relationships and PTSD and the treatments for PTSD tend to be limited to couples in which only one partner within the dyad has PTSD. No investigations, to our knowledge, have empirically examined the simultaneous provision of evidence-based PTSD treatment to both partners in an intimate relationship diagnosed with PTSD. The current case study describes two partners in a different-sex relationship, both diagnosed with current PTSD, who received individual Prolonged Exposure (PE) therapy at the same time as part of a larger randomized clinical trial.

Oligodendrocytes in Huntington's Disease: A Review of Oligodendrocyte Pathology and Current Cell Reprogramming Approaches for Oligodendrocyte Modelling of Huntington's Disease.

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder traditionally characterized by the selective loss of medium spiny neurons in the basal ganglia. However, it has become apparent that white matter injury and oligodendrocyte dysfunction precede the degeneration of medium spiny neurons, garnering interest as a key pathogenic mechanism of HD. Oligodendrocytes are glial cells found within the central nervous system involved in the production of myelin and the myelination of axons.

Psychometric evaluation and adaptation of the COMICE questionnaire for Swedish midwifery students.

Introduction: The world needs skilled, well educated, and confident midwives, but there is a lack of instruments to measure confidence in the Swedish context. The aim was to psychometrically test and adapt the COMICE (Confidence Of Midwifery students on selected midwifery Competencies at completion of Education) questionnaire on Swedish midwifery students.

Methods: This is a national cross-sectional study of midwifery students from all 13 universities in Sweden in 2016-2017.

3D ultrasound volume quantification for pediatric urinary tract dilation: a semi-automated segmentation software inter-rater analysis.

Objective: We determined the reliability of a three-dimensional (3D) ultrasound (US) segmentation software for evaluating volumetric hydronephrosis index (HI) and renal parenchymal and pelvicalyceal volume in children with urinary tract dilation (UTD).

Material And Methods: From 1/2019 to 9/2023, children clinically scheduled for a renal imaging exam to assess UTD at a single center were prospectively enrolled. They underwent a dedicated two-dimensional (2D) and 3D US renal exam.

Effects of Italian ryegrass with multi-enzymes supplementation on growth performance, gut microbial, and manure odor emission in finisher pig.

This study investigated the effects of addition of Italian ryegrass with multi-enzyme on growth performance, fecal odor, and microbiome. The experiment had a two-factor factorial design, using three levels of Italian ryegrass (0%, 2.5%, and 5%) and two levels of multi-enzymes (no enzyme and commercially recommended level) to formulate experimental diets.

Calcific aortic stenosis: omics-based target discovery and therapy development.

Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is the most common form of valvular heart disease, affecting 2% of those over age 65. Those who develop symptomatic severe AS have an average further lifespan of <2 years without valve replacement, and three-quarters of these patients will develop heart failure, undergo valve replacement, or die within 5 years. There are no approved pharmaceutical therapies for AS, due primarily to a limited understanding of the molecular mechanisms that direct CAVD progression in the complex haemodynamic environment.

Financial Toxicity and Unemployment in Patients with Major Lower Limb Amputation are High.

Background: Major limb amputation can place a significant financial burden on patients and their families because of costs of care and loss of income, encapsulated by the concept of financial toxicity.We sought to measure and understand factors associated with financial toxicity among patients undergoing major lower limb amputation for diabetic foot ulcers or peripheral arterial disease.

Methods: We identified patients in an institutional database who received lower limb amputations and excluded patients who underwent amputation due to known trauma or cancer.

Immediate effects of traditional and laser acupuncture in chronic non-specific neck pain: a randomized controlled clinical trial.

Neck pain is considered one of the most prevalent global public health problems. This study aimed to compare the immediate and subsequent effects of traditional acupuncture (TA) and laser acupuncture (LA) therapies in individuals with chronic non-specific neck pain. Eighty-four individuals were randomly allocated into 3 groups: TA (needle acupuncture treatment), LA (laser acupuncture treatment: 808 nm; 100 mW; 10 J per point), and S-LA (sham laser acupuncture).

Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic: A Randomized Clinical Trial.

Importance: The psychological morbidity experienced by physicians, advanced practice practitioners (APPs), and nurses from working during the COVID-19 pandemic includes burnout, depression, and posttraumatic stress disorder (PTSD).

Objective: To investigate whether psilocybin therapy could improve symptoms of depression, burnout, and PTSD in US clinicians who developed these symptoms from frontline clinical work during the pandemic.

Design, Setting, And Participants: This double-blind randomized clinical trial enrolled participants from February to December 2022.

Search for CP-Violating Neutrino Nonstandard Interactions with the NOvA Experiment.

This Letter reports a search for charge-parity (CP) symmetry violating nonstandard interactions (NSI) of neutrinos with matter using the NOvA Experiment, and examines their effects on the determination of the standard oscillation parameters. Data from ν_{μ}(ν[over ¯]_{μ})→ν_{μ}(ν[over ¯]_{μ}) and ν_{μ}(ν[over ¯]_{μ})→ν_{e}(ν[over ¯]_{e}) oscillation channels are used to measure the effect of the NSI parameters ϵ_{eμ} and ϵ_{eτ}. With 90% CL the magnitudes of the NSI couplings are constrained to be |ϵ_{eμ}|≲0.

A shape-reconfigurable electronic composite for stimulus customizable detection neutral plane shifting.

Three-dimensional (3D) sensors selectively measure the applied force in a particular direction through the designed shape. However, such a fixed sensor design incurs a relatively low sensitivity and narrow measurement range to forces applied from other directions. Here, we report a shape-reconfigurable electronic composite based on a stiffness-tunable polymer and a crack-based strain sensor.

m6A sites in the coding region trigger translation-dependent mRNA decay.

N-Methyladenosine (m6A) is the predominant internal RNA modification in eukaryotic messenger RNAs (mRNAs) and plays a crucial role in mRNA stability. Here, using human cells, we reveal that m6A sites in the coding sequence (CDS) trigger CDS-m6A decay (CMD), a pathway that is distinct from previously reported m6A-dependent degradation mechanisms. Importantly, CDS m6A sites act considerably faster and more efficiently than those in the 3' untranslated region, which to date have been considered the main effectors.

SeptAsTERS- SeptiCyte® RAPID as assessment tool for early recognition of sepsis - a prospective observational study.

Purpose: Early recognition of sepsis is critical to patient outcome, with mortality increasing with every hour of delay in treatment. The aim of this study was to investigate the use of a point-of-care molecular host response assay to differentiate sepsis from inflammation after surgery.

Methods: Three molecular host response assays (SeptiCyte® RAPID) were performed in 61 patients after major abdominal surgery with admission to the intensive care unit and drawn blood cultures.

Generative Pretrained Transformer for Heterogeneous Catalysts.

Discovery of novel and promising materials is a critical challenge in the field of chemistry and material science, traditionally approached through methodologies ranging from trial-and-error to machine-learning-driven inverse design. Recent studies suggest that transformer-based language models can be utilized as material generative models to expand the chemical space and explore materials with desired properties. In this work, we introduce the catalyst generative pretrained transformer (CatGPT), trained to generate string representations of inorganic catalyst structures from a vast chemical space.

The association between fluoride concentrations and spontaneous humeral fracture in first-lactation dairy cows: results from two New Zealand studies.

Aim: To assess whether the fluoride concentration in the humeri of first-lactation, 2-year-old dairy cows with a spontaneous humeral fracture is significantly different from that of first-lactation, 2-year-old dairy cows without a humeral fracture.

Methods: Two studies were conducted, the first with nine bone samples from 2-year-old, first-calving dairy cows with a humeral fracture (all from the Waikato region) age-matched with seven control bone samples from the Waikato, Bay of Plenty and Manawatū-Whanganui regions. The second study used 26 bone samples from 2-year-old, first-lactation dairy cows with a humeral fracture (from the Otago, Canterbury, Southland, West Coast, Waikato and Manawatū-Whanganui regions) age-matched with 14 control bone samples (all from the Manawatū-Whanganui region or unknown).

Underlying Mechanism of Electrolyte Compositional Engineering Based on Additive Solvation-Structure Governing Solid Electrolyte Interphase Formation in Lithium-Ion Batteries.

Substantial efforts are dedicated to optimizing the additive dosage in the electrolyte and studying its effect on solid electrolyte interphase (SEI) formation in Li-ion batteries (LIBs). This study reveals that the decomposition characteristics of the additive based on its lithium-ion solvation nature significantly contribute to controlling SEI formation. During SEI formation, the strong lithium-ion solvating additive spontaneously migrates to the negative electrode due to negative charge accumulation on the surface, and SEI reinforcement is feasible by increasing the additive dosage.

pH and Redox Dual-Responsive Nanoparticle with Enhanced Dendritic Cell Maturation for Cancer Therapy.

Type I interferons (IFNs) are essential for activating dendritic cells (DCs) and presenting tumor-associated antigens to T cells. IFNs are primarily produced from DCs among immune cells. A combination of chemotherapy and metalloimmunotherapy induces IFN production by activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway.

Modified poly-L-lysine for use as a clearing agent in pretargeted radioimmunotherapy.

Background: Pretargeted radioimmunotherapy of cancer has the potential to increase tumor specific uptake of activity when compared with conventional radioimmunotherapy. This is especially true in radioimmunotherapy with nuclides that exhibit a relatively short half-life. When administering antibody-based pretargeting molecules systemically, the antibodies often show a relatively slow clearance from the blood.

Predictors of study dropout in cognitive-behavioural therapy with a trauma focus for post-traumatic stress disorder in adults: An individual participant data meta-analysis.

Background: Available empirical evidence on participant-level factors associated with dropout from psychotherapies for post-traumatic stress disorder (PTSD) is both limited and inconclusive. More comprehensive understanding of the various factors that contribute to study dropout from cognitive-behavioural therapy with a trauma focus (CBT-TF) is crucial for enhancing treatment outcomes.

Objective: Using an individual participant data meta-analysis (IPD-MA) design, we examined participant-level predictors of study dropout from CBT-TF interventions for PTSD.

Oxytocin Reduces Noradrenergic-Induced Opioid-Like Withdrawal Symptoms in Individuals on Opioid Agonist Therapy.

Background: Intranasal administration of the neuropeptide oxytocin has been explored as a potential therapeutic agent for substance use disorder including opioid use disorder (OUD).

Methods: This phase 1, crossover, randomized, double-blind, placebo-controlled trial tested the safety, tolerability, and efficacy of intranasal oxytocin (80 IU) twice a day for 7 days in participants ( = 20) with OUD who were taking an opioid agonist therapy. In the laboratory, participants underwent opioid cue exposure paired with noradrenergic activation produced by yohimbine (32.

Molecular level insights on the pulsed electrochemical CO reduction.

Electrochemical CO reduction reaction (CORR) occurring at the electrode/electrolyte interface is sensitive to both the potential and concentration polarization. Compared to static electrolysis at a fixed potential, pulsed electrolysis with alternating anodic and cathodic potentials is an intriguing approach that not only reconstructs the surface structure, but also regulates the local pH and mass transport from the electrolyte side in the immediate vicinity of the cathode. Herein, via a combined online mass spectrometry investigation with sub-second temporal resolution and 1-dimensional diffusion profile simulations, we reveal that heightened surface CO concentration promotes CORR over H evolution for both polycrystalline Ag and Cu electrodes after anodic pulses.