Publications by authors named "Padungsri Dubbs"
Colistin- and carbapenem-resistant Acinetobacter baumannii is a serious multidrug resistant (MDR) bacterium in clinical settings. Discovery of new antibacterial drugs against MDR is facing multiple challenges in drug development. Combination of known antibiotics with a robust adjuvant might be an alternative effective strategy for MDR treatment.
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- White Spot syndrome virus (WSSV) leads to high mortality and production losses in shrimp, but Lactobacillus johnsonii KD1 shows promise as a preventative agent.
- Treatment with L. johnsonii KD1 significantly lowers mortality rates in post-larval Penaeus vannamei shrimps and enhances their immune responses while reducing WSSV presence.
- Genomic analysis of L. johnsonii KD1 reveals its close relation to a strain from wild pigs and identifies genes that suggest potential for probiotic benefits and antimicrobial properties, particularly one that might block WSSV infection.
The emergence in Southeast Asia of invasive group B (GBS) infections in adults by sequence type (ST) 283 is suggested to be associated with fish consumption. Genotyping of 55 GBS clinical isolates revealed that 33/44 invasive isolates belonged to ST283/capsular polysaccharide type (CPS) III. This included 15/16 isolates recovered from younger adults aged 16-36 years.
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- Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is primarily known for causing infections in newborns but can also lead to serious diseases in non-pregnant adults, particularly in Southeast Asia.
- A study sequenced 12 samples of the GBS ST283 genotype from adult patients in Thailand and combined this data with existing sequences to analyze the bacteria's population dynamics and transmission history.
- The research identified potential drug resistance genes and validated their resistance phenotypes through experiments, providing insights into the historical spread of GBS ST283 in the region.
Resistance to the last-line antibiotics against invasive Gram-negative bacterial infection is a rising concern in public health. Multidrug resistant (MDR) Aci46 can resist colistin and carbapenems with a minimum inhibitory concentration of 512 µg/mL as determined by microdilution method and shows no zone of inhibition by disk diffusion method. These phenotypic characteristics prompted us to further investigate the genotypic characteristics of Aci46.
View Article and Find Full Text PDFA total of 83 Acinetobacter baumannii isolates from patients attending a tertiary care university hospital in Thailand were investigated for their clonal relatedness, antimicrobial susceptibility profiles, and integron carriage. Susceptibility profiles showed that 56 (67%) of these isolates exhibited multiple drug resistance (MDR). Pulsed-field gel electrophoresis (PFGE) showed that 73% of these resistant isolates were clustered into three predominant PFGE types: 6, 7, and 36.
View Article and Find Full Text PDFIn Rhodobacter capsulatus, genes encoding enzymes of the Calvin-Benson-Bassham reductive pentose phosphate pathway are located in the cbb(I) and cbb(II) operons. Each operon contains a divergently transcribed LysR-type transcriptional activator (CbbR(I) and CbbR(II)) that regulates the expression of its cognate cbb promoter in response to an as yet unidentified effector molecule(s). Both CbbR(I) and CbbR(II) were purified, and the ability of a variety of potential effector molecules to induce changes in their DNA binding properties at their target promoters was assessed.
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