Publications by authors named "Padua C"
Article Synopsis
- This study investigates the challenging condition known as failing Fontan in patients who have undergone total cavopulmonary connection, focusing on its incidence, causes, risk factors, and treatment options.
- Out of 634 patients analyzed from 1994 to 2022, 76 were diagnosed with failing Fontan, resulting in an incidence rate of 1.48 per 100 patient-years, and key symptoms included protein-losing enteropathy and hospital readmissions.
- Key risk factors for developing failing Fontan include having a dominant right ventricle and elevated pulmonary artery pressure prior to surgery, while patients showed a survival rate of 77% ten years after failure onset; zlog-
Objective: We have left antegrade pulmonary blood flow (APBF) at bidirectional cavopulmonary shunt (BCPS) only for high-risk patients. This study evaluates the indication and the outcomes of patients with APBF, compared to those without APBF.
Methods: Patients with APBF after BCPS were identified among patients who underwent BCPS between 1997 and 2022.
Article Synopsis
- A study assessed the prevalence of veno-venous collaterals (VVCs) in patients who underwent total cavopulmonary connection (TCPC) from 1994 to 2022, finding VVCs in 15% of those evaluated.
- The research included 635 patients, most commonly diagnosed with hypoplastic left heart syndrome, with VVCs developing around 2.8 years post-surgery.
- While VVCs did not significantly affect survival rates, they were linked to an increased risk for plastic bronchitis, and interventional closure of VVCs improved oxygen saturation in 66% of treated patients.
To evaluate the relationship of aortopulmonary collaterals and the development of central pulmonary arteries during staged palliation. A total of 287 patients, who underwent staged palliation with bidirectional cavopulmonary shunt and total cavopulmonary connection between 2008 and 2019, had available angiography. Pulmonary artery index was calculated using pulmonary angiography as described by Nakata and colleagues.
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- A study was done to understand how often colorectal cancer (CRC) happens after colonoscopies in patients with inflammatory bowel disease (IBD).
- The research found that about 30.8% of IBD patients developed post-colonoscopy CRC within three years, compared to just 6.8% in those without IBD.
- Also, patients with ulcerative colitis had a higher rate of this cancer than those with Crohn's Disease, which means more research is needed to understand why this happens.
Article Synopsis
- The study aimed to assess heart function and valve regurgitation in babies who underwent the Norwood procedure over a period from 2001 to 2020.
- Researchers analyzed echocardiograms of 335 patients to compare outcomes between those who had a modified Blalock-Taussig shunt versus a right ventricle to pulmonary artery conduit.
- Results showed that although ventricular function initially worsened with the Blalock-Taussig shunt, it improved after the procedure compared to the conduit approach, but differences in valve regurgitation were less pronounced after the second stage of treatment.
Article Synopsis
- The study aimed to find early postoperative indicators that could predict complications after total cavopulmonary connection surgery, analyzing factors like pulmonary artery pressure, arterial pressure, oxygen saturation, and lactate levels.
- A total of 249 patients, primarily young children, were evaluated, with specific postoperative measurements showing significant correlations with various complications, such as chest tube drainage and adverse events.
- Key findings included optimal cut-off values for pulmonary artery pressures and mean arterial pressures that could help predict complications, emphasizing the importance of early monitoring in improving patient outcomes.
Article Synopsis
- The study compares outcomes between infants with univentricular hearts who received either ductus stenting or surgical systemic-to-pulmonary shunt (SPS) for initial palliation from 2009 to 2022.
- Hospital mortality rates were similar for both groups, but those with ductus stenting had significantly shorter ICU and hospital stays despite experiencing higher rates of acute complications.
- The likelihood of reaching stage II palliations was nearly the same for both groups, but patients with SPS had better ratios of left to right pulmonary artery areas at stage II.
Incidence of thromboembolism and associated factors in multiple myeloma patients treated with immunomodulatory drugs: a retrospective analysis in Belo Horizonte, Brazil.
Support Care Cancer
December 2023
Purpose: The use of immunomodulators in the treatment of multiple myeloma (MM) patients has been associated with venous thromboembolism (VTE). Due to the increase in mortality of cancer patients, venous thromboembolism is an important concern for newly diagnosed multiple myeloma (NDMM) patients. The aim of this study was to determine the incidence of thromboembolic events and evaluate associated risk factors among Brazilian NDMM patients using immunomodulators.
View Article and Find Full Text PDFImpact of aortopulmonary collaterals on adverse events after total cavopulmonary connection.
Eur J Cardiothorac Surg
December 2023
Article Synopsis
- This study focused on assessing how aortopulmonary collaterals (APCs) influence patient outcomes following total cavopulmonary connection (TCPC) surgery.
- Out of 585 patients analyzed, 36% had APCs before the surgery, and 14% post-surgery, with closures occurring at various stages.
- The findings revealed that APCs before TCPC were linked to complications like chylothorax, while those after TCPC were associated with protein-losing enteropathy (PLE) and plastic bronchitis (PB), suggesting that APCs impact lymph drainage and overall recovery.
Olaparib improved PFS and OS across subgroups of BRCA1/2mut #prostatecancer patients in the PROFOUND phase III trial.
View Article and Find Full Text PDFBackground: This study aimed to assess the impact of caloric intake and weight-for-age-Z-score after the Norwood procedure on the outcome of bidirectional cavopulmonary shunt.
Methods: A total of 153 neonates who underwent the Norwood procedure between 2012 and 2020 were surveyed. Postoperative daily caloric intake and weight-for-age-Z-score up to five months were calculated, and their impact on outcome after bidirectional cavopulmonary shunt was analysed.
Objective: The purpose of this study is to evaluate the incidence and outcomes regarding tachyarrhythmia in patients after total cavopulmonary connection.
Methods: A retrospective analysis of 620 patients who underwent total cavopulmonary connection between 1994 and 2021 at our institution was performed. Incidence of tachyarrhythmia was depicted, and results after onset of tachyarrhythmia were evaluated.
Background: Survival in multiple myeloma (MM) has improved in the past years with the introduction of immunomodulators and proteasome inhibitors. However, chemotherapyinduced peripheral neuropathy (CIPN) is associated with both drug classes affecting Health- Related Quality of Life (HRQoL) and activities of daily living (ADL).
Objective: We evaluated CIPN in MM patients to identify associated factors and impacts on HRQoL and ADL.
Introduction: Elderly with cancer often have multimorbidity, which determines a higher risk of polypharmacy. This is related to negative clinical results such as adverse drug reaction and emergence service visits. Furthermore, polypharmacy increases the risk of using potentially inappropriate medications.
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- * Mycobacterium kansasii was the most common NTM identified, present in about 11.5% of analyzed patients.
- * Of the patients who met the diagnostic criteria, nearly half received treatment, with a high cure rate of about 75.8% among those treated, with dyspnea and cough being the most common symptoms.
Purpose: Verify the association between anticholinergic burden and health-related quality of life of patients with multiple myeloma.
Methods: Cross-sectional study with multiple myeloma outpatient from a state capital city in southeastern Brazil. Sociodemographic, clinical, and pharmacotherapeutic variables were collected by interview.
Objective: To compare viral suppression in treatment-naïve adults starting antiretroviral therapy with dolutegravir (50mg)- and efavirenz (600mg)-based regimens.
Methods: We analyzed secondary data from Brazilian health information systems of people living with human immunodeficiency virus who started antiretroviral therapy between 2015 and 2017 in Minas Gerais, Brazil. The outcome was viral suppression, defined as the achievement of the first viral load <50 copies/mL within 12 months after initiating antiretroviral therapy.
Comparison of three risk assessment models for thromboembolism in multiple myeloma patients receiving immunomodulators: a Brazilian historical cohort.
J Thromb Thrombolysis
July 2023
Venous thromboembolism (VTE) is among the complications of Multiple Myeloma (MM) and may occur in up to 10% of this patient population. However, medications used in MM therapy such as immunomodulators (IMID) may raise these rates. Thus, risk prediction models have been developed to quantify the risk of VTE in MM patients.
View Article and Find Full Text PDFBackground: Men who have sex with men (MSM) and transgender women (TGW) are disproportionately affected by HIV, with much higher incidence and prevalence rates than in the general population in different countries. There are several barriers to testing among MSM and TGW, such as low risk perception, anticipation of HIV-related stigma, discrimination of sexual orientation, in addition to difficulties related to care and access to health services. Therefore, analyzing the available evidence of the effectiveness of strategies for scaling up HIV testing among key populations is essential to point out potential knowledge gaps which may need to be addressed and develop public health policies to promote testing and early diagnosis of HIV infection.
View Article and Find Full Text PDFFactors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019.
Diagnostics (Basel)
March 2023
(1) Background: Infection with the Human Immunodeficiency Virus (HIV) is a significant challenge for tuberculosis (TB) control, with increasing mortality rates worldwide. Moreover, the loss to follow-up is very high, with low adherence to treatment, resulting in unfavorable endpoints. This study aimed to analyze the effectiveness of TB treatment in patients coinfected with HIV/AIDS and its associated factors.
View Article and Find Full Text PDFBackground: Based on PROfound, olaparib is approved for patients with metastatic castration-resistant prostate cancer following disease progression on at least enzalutamide or abiraterone and who carry relevant alterations in DNA repair genes. To facilitate continued olaparib treatment as long as the patient derives benefit, we describe further safety assessments from PROfound focusing on the four most common adverse events (AEs) and events of special interest.
Methods: Patients were randomized (2:1) to olaparib tablets (300 mg bid) or control (enzalutamide or abiraterone) until disease progression or unacceptable toxicity.
Purpose: Successful implementation of genomic testing in clinical practice is critical for identification of men with metastatic castration-resistant prostate cancer (mCRPC) eligible for olaparib and future molecularly targeted therapies.
Patients And Methods: An investigational clinical trial assay, based on the FoundationOneCDx tissue test, was used to prospectively identify patients with qualifying homologous recombination repair gene alterations in the phase III PROfound study. Evaluation of next-generation sequencing (NGS) tissue test outcome against preanalytic parameters was performed to identify key factors influencing NGS result generation.
Effect of therapeutic regimens and polypharmacy on health-related quality of life of people with multiple myeloma: a cross-sectional study in Belo Horizonte, Brazil.
Curr Med Res Opin
August 2022
Objective: Multiple myeloma (MM) is an incurable hematological cancer and its treatment is geared to promote better Health-Related Quality of Life (HRQoL). We aimed to assess HRQoL and compare scores between variables on therapeutic regimens and polypharmacy in MM patients.
Methods: This cross-sectional study was performed from April/2019 to February/2020 in Belo Horizonte, Brazil.