Effect of consumption for breast feeding among postnatal Indian mothers.

Breast milk is a unique form of nutrition for babies since it provides all of the essential nutrients for growth and development. Breastfeeding may also play a role in decreasing postpartum depression, and reduced the risk of breast and ovarian cancer in future. Garlic has been used as a galactogogue in India since many years.

MutaXome: A Novel Database for Identified Somatic Variations of Analyzed Cancer Exome Datasets.

Advancements in the field of cancer research have enabled researchers and clinicians to access a massive amount of data to aid cancer patients and to add to the existing knowledge of research. However, despite the existence of reliable sources for extricating this data, it remains a challenge to accurately comprehend and draw conclusions based on the entirety of available information. Therefore, the current study aimed to design and develop a database for the identified variants of 5 different cancer types using 20 different cancer exomes.

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) is spreading, as the causative pathogen of coronavirus disease-19 (COVID-19). It has infected more than 1.65 billion people all over the world since it was discovered and reported 3.

Association between alcohol-induced oxidative stress and membrane properties in synaptosomes: A protective role of vitamin E.

Chronic and excessive alcohol consumption leads to various neurological diseases. Synaptosomes are ideal organelles to study the functional properties of the brain in alcoholism. This study focuses on the association between oxidative stress and synaptosomal membrane properties in alcohol treated rats.

Association between alcohol-induced erythrocyte membrane alterations and hemolysis in chronic alcoholics.

The present study aimed to understand the association between erythrocyte membrane alterations and hemolysis in chronic alcoholics. Study was conducted on human male volunteers aged between 35-45 years with a drinking history of 8-10 years. Results showed that plasma marker enzymes AST, ALT, ALP and γGT were increased in alcoholic subjects.

Modulatory role of Pterocarpus santalinus against alcohol-induced liver oxidative/nitrosative damage in rats.

Pterocarpus santalinus, a traditional medicinal plant has shown protective mechanisms against various complications. The aim of the present study is to evaluate therapeutic efficacy of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced oxidative/nitrosative stress leading to hepatotoxicity.

Nephro-protective action of P. santalinus against alcohol-induced biochemical alterations and oxidative damage in rats.

The present study investigated the antioxidant potential of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced nephro-toxicity. The results indicated an increase in the concentration of kidney damage plasma markers, urea and creatinine with a concomitant decrease in the concentration of uric acid in alcohol-administered rats.

Effect of acupressure vs reflexology on pre-menstrual syndrome among adolescent girls--a pilot study.

Premenstrual syndrome is the most common of gynaecologic complaints. It affects half of all female adolescents today and represents the leading cause of college/school absenteeism among that population. It was sought to assess the effectiveness of acupressure Vs reflexology on premenstrual syndrome among adolescents.

Influence of Altered Hormonal Status on Platelet 5-HT and MAO-B Activity in Cigarette Smokers.

The present study was designed to understand the cigarette smoking-induced alterations in hormones and the resulting changes in platelet serotonin (5-hydroxytryptamine, 5-HT) and monoamine oxidase (MAO-B) activity in chronic smokers. Human male volunteers aged 35 ± 8 years, were divided into two groups, namely controls and smokers (12 ± 2 cigarettes per day for 7-10 years). Results showed that cigarette smoking significantly (p < 0.

Comparative study of glycated hemoglobin by ion exchange chromatography and affinity binding nycocard reader in type 2 diabetes mellitus.

The aim of this study was to compare the level of glycated hemoglobin (HbA1c) in type 2 Diabetes Mellitus (DM) patients by two different methods namely Ion Exchange Chromatography and Affinity Binding Nycocard Reader. This is a cross-sectional study conducted on confirmed type 2 diabetes mellitus patients (n = 100) who visited Out Patients Department of the Universal College of Medical Sciences Teaching hospital, Bhairahawa, Nepal from November 2012 to March 2013. The diagnosis of diabetes mellitus was done on the basis of their fasting (164.

Alcohol-induced oxidative stress in rat liver microsomes: Protective effect of Emblica officinalis.

The protective effect of Emblica officinalis fruit extract (EFE) against alcohol-induced oxidative damage in liver microsomes was investigated in rats. EFE (250mg/kg b.wt/day) and alcohol (5g/kg b.

Gender differences in alcohol-induced oxidative stress and altered membrane properties in erythrocytes of rats.

Alcohol-induced oxidative stress leads to imbalance between reactive oxygen species (ROS) and the antioxidant defense system, resulting in oxidative damage to membrane components such as lipids and proteins, ultimately altering membrane properties. In this study, we assessed oxidative stress status and alterations in erythrocyte membrane properties in alcohol-administered rats with respect to gender difference. Alcohol (20% v/v) administered rats of both genders showed significant changes in plasma lipid profile with elevated nitrite/nitrate levels.

Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties.

Chronic alcohol consumption causes numerous biochemical and biophysical changes in the central nervous system, in which mitochondria is the primary organelle affected. In the present study, we hypothesized that alcohol alters the mitochondrial membrane properties and leads to mitochondrial dysfunction via mitochondrial reactive oxygen species (mROS) and reactive nitrogen species (RNS). Alcohol-induced hypoxia further enhances these effects.

Aegle marmelos fruit extract attenuates isoproterenol-induced oxidative stress in rats.

Myocardial infarction is a major public health concern and the leading cause of death throughout the world. The present study investigates the ability of Aegle marmelos fruit extract to prevent pathological changes and oxidative stress after isoproterenol induced myocardial infarction in rats. In vitro studies showed that Aegle marmelos fruit extract possesses antioxidant activity.

Protective Effect of Emblica officinalis Against Alcohol-Induced Hepatic Injury by Ameliorating Oxidative Stress in Rats.

The effect of Emblica officinalis fruit extract (EFE) against alcohol-induced hepatic damage in rats was investigated in the present study. In vitro studies showed that EFE possesses antioxidant as well nitric oxide (NO) scavenging activity. In vivo administration of alcohol (5 g/kg b.

Ethanol induced adaptive changes in blood for the pathological and toxicological effects of chronic ethanol consumption in humans.

Alcohol consumption is associated with a number of toxicological changes in blood and the oxidant-antioxidant system. The present study was performed to investigate the alcohol induced toxicological, pathological changes in blood and an adaptive role of erythrocyte antioxidant system in chronic alcoholics. Human male volunteers aged 44±6 years with similar dietary habits were divided into two groups, namely non-alcoholic controls and chronic alcoholics.

Emblica officinalis ameliorates alcohol-induced brain mitochondrial dysfunction in rats.

The fruit of Emblica officinalis has been used in the Ayurvedic system of medicine for the treatment of different ailments and is also an ingredient of various traditional medicinal herbal formulations in India and other countries. To investigate the protective effect of Emblica officinalis fruit extract (EFE) against alcohol-induced brain mitochondrial dysfunction, male Wistar rats were orally administered 20% alcohol (5 g/kg of body weight/day) and EFE (250 mg/kg of body weight/day) for 60 days. Alcohol-treated rats showed significantly lowered activities of mitochondrial antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and reduced glutathione compared with those of experimental control rats.

Amelioration of alcohol-induced oxidative stress by Emblica officinalis (amla) in rats.

The present study was aimed at investigating the ameliorative effect of Emblica (Phyllanthus Emblica L) fruit extract (EFE) against alcohol-induced oxidative changes in plasma biochemical profile in rats. Alcohol administration (5 g/kg body wt/day) for 60 days resulted in significantly (P<0.05) higher levels of plasma nitrite/nitrate (NOx), total bilirubin, creatinine, and abnormalities in lipid and lipoproteins.

Chronic cigarette smoking alters erythrocyte membrane lipid composition and properties in male human volunteers.

Cigarette smoking is a major lifestyle factor influencing the health of human beings. The present study investigates smoking induced alterations on the erythrocyte membrane lipid composition, fluidity and the role of nitric oxide. Thirty experimental and control subjects (age 35+/-8) were selected for the study.

Smoking-induced alterations in platelet membrane fluidity and Na(+)/K(+)-ATPase activity in chronic cigarette smokers.

Aim: Cigarette smoking is a recognized risk factor for cardiovascular diseases and has been implicated in the pathogenesis of atherosclerosis. Platelet adhesiveness and aggregation increases as a result of smoking. Cigarette smoking modifies haemostatic parameters via thrombosis with a consequently higher rate of cardiovascular events, but smoking-induced alterations of platelet membrane fluidity and other changes have not been studied.

Molecular details of Bax activation, oligomerization, and membrane insertion.

Bax and Bid are pro-apoptotic members of the Bcl-2 protein family. Upon cleavage by caspase-8, Bid activates Bax. Activated Bax inserts into the mitochondrial outer membrane forming oligomers which lead to membrane poration, release of cytochrome c, and apoptosis.

Topology of the amphipathic helices of the colicin A pore-forming domain in E. coli lipid membranes studied by pulse EPR.

Colicin A is a water-soluble pore-forming protein that kills cells, which are not protected by an immunity protein, by inserting specific helical segments of the toxin subdomain into the cytoplasmic membrane to form voltage-dependent ion channels. This leads to depolarization of the cell membrane followed by depletion of the intracellular ATP levels and finally to cell death. The formation of the integral membrane voltage-gated ion channel is known to be accompanied by a conformational transition.

Emblica officinalis protects against alcohol-induced liver mitochondrial dysfunction in rats.

The protective effect of Emblica officinalis, a commonly used botanical in many Ayurvedic preparations, was investigated for its effects on liver mitochondria of ethanol-administered rats. Oxidative stress and reactive oxygen species-mediated toxicity are considered two of the key underlying mechanisms responsible for alcohol-induced liver injury and mitochondrial dysfunction. Alcohol-administered rats showed a significant elevation of plasma transaminases (aspartate and alanine aminotransferases), alkaline phosphatase, and gamma-glutamyl transferase compared to control rats.

Modulatory role of Emblica officinalis against alcohol induced biochemical and biophysical changes in rat erythrocyte membranes.

This study investigated the protective effect of Emblica officinalis against alcohol-induced biochemical and biophysical changes in rat erythrocyte membranes. Thirty-two male rats were divided into four groups (n=8 in each group): control (C), alcohol (A), alcohol plus Emblica fruit extract (A+EFE) and Emblica fruit extract (EFE) alone. Administration of twenty percent alcohol (5 g/kg body weight) to rats significantly increased cholesterol/phospholipid (C/P) ratio, lipid peroxidation and the activities of Na(+)/K(+) and Mg(2+) ATPases in erythrocyte membranes as well as augmented nitric oxide (NO) levels.

Bidis--hand-rolled, Indian cigarettes: induced biochemical changes in plasma and red cell membranes of human male volunteers.

Objective: To investigate the effect of bidi smoking on erythrocyte antioxidant status, membrane fluidity.

Design And Methods: Thirty experimental and control subjects (mean age 35+/-5) were selected for the study. Experimental subjects smoke 22+/-4 bidis per day for 8-10 years.