Publications by authors named "Padmamalini Thulasiraman"
Objective: The aim of the present study was to examine whether GLUT1 was involved in the antiproliferative activity of curcumin and doxorubicin by understanding mechanistically how curcumin regulated GLUT1.
Methods: Expression level of GLUT1 in MCF-7 and MDA-MB-231 cells were quantitated using quantitative real-time PCR and western blot. GLUT1 activity was inhibited in MDA-MB-231 cells with the pharmacological inhibitor WZB117 to assess the anti-proliferative effects of doxorubicin using MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide).
Article Synopsis
- COVID-19, caused by the SARS-CoV-2 virus, has severely affected the oncology community, particularly patients with ovarian cancer (OC), facing challenges like delayed diagnosis and treatment.
- Patients are resorting to telemedicine for follow-ups, leading to increased anxiety and depression due to the postponement of crucial cancer care.
- The article reviews how the pandemic has impacted OC diagnosis and treatment, discusses psychological effects on patients, and explores alternative strategies to minimize hospital visits while combating the spread of the virus.
The link between Neuraminidase 1 (Neu1) and cancer development has been highlighted in numerous studies. In an effort to understand the role of Neu1 in mammary carcinoma cells, we evaluated the effect of Neu1 on controlling cell proliferation and apoptosis, as well as regulating the expression of cadherins. By blocking the activity of Neu1 with oseltamivir phosphate or using siRNA to silence the Neu1 protein, we observed suppression of cell growth in MCF-7 and MDA-MB-231 cells.
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- Retinoic acid (RA) shows potential in treating diseases like cancer due to its ability to prevent cell death, but resistance to RA poses a challenge in therapy.
- * The study explores how curcumin can make triple-negative breast cancer (TNBC) cells more sensitive to RA-induced apoptosis by enhancing the expression of CRABPII and retinoic acid receptors (RARs).
- * Results indicate that combining curcumin with RA significantly increases cell death in TNBC cells, while reducing CRABPII expression reverses this sensitization effect.
Understanding the link between chemoresistance and cancer progression may identify future targeted therapy for breast cancer. One of the mechanisms by which chemoresistance is attained in cancer cells is mediated through the expression of multidrug resistance proteins (MRPs). Acquiring drug resistance has been correlated to the emergence of metastasis, accounting for the progression of the disease.
View Article and Find Full Text PDFBackground: A major obstacle in the use of retinoid therapy in cancer is the resistance to this agent in tumors. Retinoic acid facilitates the growth of mammary carcinoma cells which express high levels of fatty acid-binding protein 5 (FABP5). This protein delivers retinoic acid to peroxisome proliferator-activated receptor β/δ (PPARβ/δ) that targets genes involved in cell proliferation and survival.
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