Publications by authors named "Padmaja Mekala"
Introduction Chronic hyperglycemia is a key factor in the development of diabetic peripheral neuropathy (DPN), contributing significantly to the progression of this condition through the induction of oxidative stress. Elevated blood glucose levels lead to increased production of reactive oxygen species (ROS), which cause damage to neuronal cells and exacerbate neuropathic symptoms. Alpha-lipoic acid (ALA) is a potent antioxidant that neutralizes ROS and reduces oxidative damage.
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- * It includes a dataset of 4,096 participants across 18 states, with blood samples collected for detailed analysis and neuroimaging data for 137 participants.
- * The publicly available datasets aim to help researchers identify risk factors linked to cognitive impairment and dementia in older adults.
Introduction: Prior estimates of dementia prevalence in India were based on samples from selected communities, inadequately representing the national and state populations.
Methods: From the Longitudinal Aging Study in India (LASI) we recruited a sample of adults ages 60+ and administered a rich battery of neuropsychological tests and an informant interview in 2018 through 2020. We obtained a clinical consensus rating of dementia status for a subsample (N = 2528), fitted a logistic model for dementia status on this subsample, and then imputed dementia status for all other LASI respondents aged 60+ (N = 28,949).
Article Synopsis
- Healthcare workers in India were given a specific hydroxychloroquine (HCQ) dosage regimen as a preventive measure against COVID-19, but there was a lack of comprehensive data on how this drug behaves in their population.* -
- A multicentric study involved 121 participants providing multiple blood samples to analyze HCQ concentrations, using advanced lab techniques for accurate measurement and pharmacokinetic modeling.* -
- The findings indicated that the existing dosage regimen resulted in drug levels below the effective threshold, leading to a recommendation for a new weight-based dosage to ensure sufficient HCQ concentrations.*
The Harmonized Diagnostic Assessment of Dementia for Longitudinal Aging Study in India (LASI-DAD) is a population-representative, prospective cohort study of late-life cognition and dementia. It is part of an ongoing international research collaboration that aims to measure and understand cognitive impairment and dementia risk by collecting a set of cognitive and neuropsychological assessments and informant reports, referred to as the Harmonized Cognitive Assessment Protocol (HCAP). LASI-DAD provides nationally representative data drawn from a subsample of the ongoing Longitudinal Aging Study in India (LASI).
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