Publications by authors named "Padma S"

Article Synopsis
  • - Researchers isolated a new lectin, named hRTL, from a marine sponge, which belongs to the galectin family and shows high similarity to another galectin called CCL.
  • - hRTL is a tetramer composed of 141 amino acids and features a unique 23 amino acid signal peptide that gets cleaved after translation, differing from most galectins which usually have acetylated modifications.
  • - The hRTL lectin binds strongly to specific glycan structures and has been shown to induce cytotoxic effects in colorectal cancer cells expressing certain antigens, suggesting potential therapeutic implications.
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Article Synopsis
  • - SeviL, a lectin from mussels, has been shown to induce apoptosis in HeLa ovarian cancer cells and promote M1 polarization in macrophage cell lines at low concentrations.
  • - Low levels of SeviL decrease the growth of monocyte and basophil cell lines but stimulate proliferation in RAW264.7 macrophages, evidenced by changes in cell shape and up-regulation of mitochondrial proteins.
  • - Treatment with SeviL leads to increased secretion of pro-inflammatory cytokines and activation of various signaling pathways, indicating its role in regulating cell behaviors like proliferation and death in macrophages, which may impact immune responses in living organisms.
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Unlabelled: The sandal spike disease (SSD), related to . Phytoplasma asteris' (Aster Yellows group), poses a significant threat to Indian sandalwood ( L.), making it the second most expensive wood globally due to declining population density.

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Objective: To assess the therapeutic outcome and factors predicting remission in hyperthyroid patients treated with low-dose I-131 (radioactive iodine) from a tertiary care hospital in South India.

Methods: This 20-year single-institutional retrospective study was carried out on 3891 hyperthyroid adult patients. Only those patients with complete clinical records were audited.

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The present study focuses on removing hexavalent chromium (Cr(VI)) using indigenous metal-resistant bacterial strains isolated from a common industrial effluent treatment plant, a contaminated site in Vishakhapatnam. Three high metal-resistant isolates were screened by growing them in nutrient agar media containing different Cr(VI) concentrations for 24 h at 35 ± 2 °C. The three strains' minimum inhibitory concentrations of Cr(VI) were examined at neutral pH and 35 ± 2 °C temperature.

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  • The study investigates two new glycoconjugates, Z-P(Gly)-Glu and Z-F(4-N)-Glu, which can form effective self-healing gels in water and various organic solvents, highlighting their ambidextrous supergelator properties.
  • Characterization revealed that these gelators exhibit β-sheet structures that lead to the formation of unique left-handed helical fibers, potentially useful for biomedical applications due to their benign and non-toxic nature.
  • The research further demonstrates the gels' effectiveness in drug delivery, such as streptomycin, along with favorable cell compatibility and antimicrobial properties, paving the way for innovative therapeutic uses.
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Ulcerative colitis (UC) is a chronic inflammatory manifestation of the human colon that is linked with colorectal cancer. Development of an appropriate animal model is crucial to study the immunopathophysiology of UC wherein chemical induction is the most popular method of choice. However, unavailability of an optimum experimental model limits the success of this method.

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Colorectal cancer (CRC) is one of the most common cancers and is the second-highest in cancer-related deaths worldwide. The changes in gut homeostasis and microbial dysbiosis lead to the initiation of the tumorigenesis process. Several pathogenic gram-negative bacteria including are the principal contributors to the induction and pathogenesis of CRC.

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Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. We aimed to compare the performance of SUV reduction (ΔSUV) and the PET ratio (rPET) versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients undergoing F-FDG PET-CT. Fifty-two patients with biopsy-proven HL (aged 8-16 years) were enrolled at baseline, interim (after the second or third chemotherapy round) and post-therapy (on completion of first-line chemotherapy).

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The Sandalwood Spike disease (SSD)-related to '. Phytoplasma asteris' has threatened the existence of sandalwood in India. The epidemiology of SSD is still poorly understood despite the efforts to understand the involvement of insect vectors in SSD transmission and alternate plant hosts over the last two decades.

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In recent days, the usage of biological and non-biological pollutants increased which poses a significant threat to environmental and biological systems. Therefore, the present aim is to develop effective methods to treat such pollutants by using highly stable and small-sized Schiff base ligand capped silver nanoparticles (AgNPs) with a face-centered cubic (fcc) crystalline structure and the size range is 5-10 nm. The potent role of the resulting synthesized AgNPs was found to be on multiple platforms such as catalyst, sensor, antioxidant, and antimicrobial disinfectant.

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A novel, mustard yellow-pigmented aerobic bacterial strain designated AR01 was isolated from hypocotyl tissue of a sandalwood seedling from Bangalore, India. The 16S rRNA gene of strain AR01 had the highest 98.97% sequence similarity with Rothia halotolerans YIM 90716 (KCTC 19172) followed by Rothia kristinae PM 129 (NBRC 15354) (97.

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Background: To determine locations, relative frequencies, imaging features, and pattern of distribution of extrahepatic metastasis from hepatocellular carcinoma (HCC) on 2-deoxy-2-[fluorine-18]fluoro-D-glucose (F-FDG) PET CT.

Methods: FDG PET CT scans of 224 consecutive patients of HCC acquired between 2010 and 2018 were reviewed. Fifty-six patients detected with extrahepatic metastasis on FDG PET CT were retrospectively analyzed.

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Purpose: To evaluate the diagnostic performance of regional fluorine-18 fluorodeoxyglucose (F-FDG) positron emission tomography-computed tomography (PET-CT) in patients with skull base osteomyelitis (SBO) and to compare with magnetic resonance imaging (MRI) whenever available.

Materials And Methods: A total of 77 patients (male:female = 56:21; mean age 66.4 ± 9.

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Objective: To assess the diagnostic performance of Gallium-68 prostate-specific membrane antigen positron emission tomography-computed tomography (Ga-PSMA PET-CT) in primary lymphnodal staging of patients with intermediate-risk and high-risk prostate cancer and to compare it with multiparametric MRI (mp-MRI) whenever available.

Materials And Methods: Ga-PSMA PET-CT scans of 51 patients (average age 66.0 ± 7.

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Eye movement evaluation is vital for diagnosis of various ophthalmological and neurological disorders. The present study proposes a novel, noninvasive, wearable device to acquire the eye movement based on a Fiber Bragg Grating (FBG) Sensor. The proposed Fiber Bragg Grating Eye Tracker (FBGET) can capture the displacement of the eyeball during its movements in the form of strain variations on a cantilever.

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Arterial pulse is an established source of information for the clinical assessment of cardiovascular health. The central aortic pressure is known to be a better predictor of cardiovascular status than the peripheral pressure. The carotid arterial pulse is considered to be the best indicator of the central aortic pressure.

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The maximum level of voluntary bite force, which results from the combined action of muscle of mastication, joints, and teeth, i.e., craniomandibular structure, is considered as one of the major indicators for the functional state of the masticatory system.

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Papillary and follicular cancers of thyroid are the most common varieties of differentiated thyroid cancers exhibiting excellent long-term prognosis when carefully managed. Being a slow-growing malignancy, guidelines exist on the staging, preoperative risk stratification, and management of these cancers to increase the overall survival of these patients. Radioactive iodine has a central role in differentiated thyroid malignancies.

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(18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging modality in adult oncological practice. Its role in childhood malignancies needs to be discussed as paediatric malignancies differ from adults in tumor subtypes and they have different tumor biology and FDG uptake patterns. This is also compounded by smaller body mass, dosimetric restrictions, and physiological factors that can affect the FDG uptake.

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Improvements in emergency medicine in the form of efficient life supporting systems and intensive care have increased the survival rate in critically injured patients; however, in some cases, severe brain and spinal cord injuries can result in a locked-in syndrome or other forms of paralysis, and communication with these patients may become restricted or impossible. The present study proposes a noninvasive, real-time communication assistive methodology for those with restricted communication ability, employing a fiber Bragg grating (FBG) sensor. The communication assistive methodology comprises a breath pattern analyzer using an FBG sensor, which acquires the exhalation force that is converted into strain variations on a cantilever.

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The present study reports an in vivo, novel methodology for the dynamic measurement of the bite force generated by individual tooth using a Fiber Bragg Grating Bite Force Recorder (FBGBFR). Bite force is considered as one of the major indicators of the functional state of the masticatory system, which is dependent on the craniomandibular structure comprising functional components such as muscles of mastication, joints and teeth. The proposed FBGBFR is an intra-oral device, developed for the transduction of the bite force exerted at the occlusal surface, into strain variations on a base plate, which in turn is sensed by the FBG sensor bonded over it.

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In this paper, we have developed an efficient wavelet based approximation method to biofilm model under steady state arising in enzyme kinetics. Chebyshev wavelet based approximation method is successfully introduced in solving nonlinear steady state biofilm reaction model. To the best of our knowledge, until now there is no rigorous wavelet based solution has been addressed for the proposed model.

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