Exploratory pharmacodynamics and efficacy of PF-06817024 in a Phase 1 study of patients with chronic rhinosinusitis and atopic dermatitis.

PF-06817024 is a humanized antibody against interleukin-33 that has the potential to inhibit type 2 inflammation. An exploratory analysis of the pharmacodynamics and clinical effects of single and repeat doses of PF-06817024 was assessed in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and patients with moderate-to-severe atopic dermatitis (AD), respectively, as part of a Phase 1, first-in-human study. Rhinosinusitis symptoms were improved, and nasal polyps were decreased in size following treatment with PF-06817024 in patients with CRSwNP.

Oral manifestations in COVID-19 patients: An observational study.

Background: Viral diseases continue to emerge as a threat to mankind and are a serious concern to public health. The latest lethal SARS-CoV-2 or COVID-19 is a highly contagious disease, which propagated quickly across the globe. Similar to other influenza-like viral infections, symptoms such as fever, dry cough, myalgia, arthralgia, headache, diarrhea, dyspnea, and fatigue were reported among COVID-19 patients.

Correlation of dental anxiety with oral health status and treatment needs among 12-year old indian school going children.

Background And Aim: Dental anxiety is primarily associated with learning negative behaviour which may be attributed to the aggressive condition process during childhood and adolescence and is considered to be the main reason for avoiding dental care. Hence the present study aimed to assess the correlation of Dental Anxiety with Oral Health Status and Treatment Needs.

Methods: Cross sectional study was carried out among 12-year old school going children of Hyderabad City, India.

Effect of motivation on oral hygiene and caries status among young adults in Hyderabad City.

Background: Motivation is a theoretical construct used to explain behavior, it gives the reasons for people's action, desires, and needs, and it drives an individual to a certain action and determines human behavior.

Aim: To determine the effect of motivation on oral hygiene and caries status among young adults in Hyderabad city.

Settings And Design: A cross-sectional study was carried out among 18-20-year-old engineering college students of Nagole Institute of Technology and Sciences.

Does academic performance influence personal growth initiative? An institutional-based study among undergraduate dental students.

Introduction: Personal growth initiative (PGI) is an "intentional involvement in changing and developing as a person." A student who has higher level of PGI is said to show higher academic performance because higher level of PGI might increase the student's contribution and achievement in life.

Aim: This study aimed to explore the association between academic performance and PGI among undergraduate dental students.

Impact of Health Locus of Control on Oral Health Status among a Cohort of IT Professionals.

Purpose: To assess the relationship between health locus of control and oral health status among Information Technology (IT) professionals in Hyderabad, India.

Materials And Methods: A cross-sectional questionnaire study was carried out among IT employees in Hyderabad city. The behaviour, attitude and perceptions of individuals towards health were assessed using the multidimensional health locus of control scale.

Determining Caries Activity Using Oratest Among 12-to 15-year-old Children.

Purpose: Dental caries is the primary pathological cause of early tooth loss in children, which may lead to malnutrition and other health problems. Identification of patients with active carious lesions and at high risk for caries can help to dramatically decrease the disease prevalence. Thus, recognising the importance of early diagnosis of caries, the present study was carried out to correlate caries with oral microflora using Oratest among 12- to 15-year-old schoolchildren.

Assessment of work engagement among dentists in Hyderabad.

Background: Work engagement has been conceptualized as a relatively stable phenomenon, partly explained by the presence of specific job and organizational characteristics. Work engagement is important to the dental workforce worldwide, and the lack of it has been known to cause burnout. Positivity among dentists is essential as it is directly proportional to the patient's satisfaction towards the dental care.

Association Between Social Anxiety with Oral Hygiene Status and Tongue Coating among Patients with Subjective Halitosis.

Halitosis is a universal affliction suffered by many individuals irrespective of age, sex and social status. Concern about oral malodor can significantly impede an individual's personal, professional and public life which can lead to the development of social anxiety. The present study was undertaken to assess the association between social anxiety with oral hygiene status and tongue coating among patients with subjective halitosis.

Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn's Disease.

Objective: To define pharmacodynamic biomarkers in the peripheral blood of patients with Crohn's disease [CD] after treatment with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody.

Methods: In this Phase 2, randomised, double-blind, controlled study [OPERA], blood samples were analysed from patients with moderate to severe active CD who received placebo or 22.5 mg, 75 mg, or 225 mg of PF-00547659 subcutaneously at baseline and at Weeks 4 and 8, with follow-up at Week 12.

Effect of Frequency and Duration of Tobacco Use on Oral Mucosal Lesions – A Cross-Sectional Study among Tobacco Users in Hyderabad, India.

Purpose: Tobacco use is one of the most important risk factors for the development of oral mucosal lesions including oral pre-cancer and cancer. The type and location of the lesion varies with the type of tobacco used, the way it is used, and the frequency and duration of use. Hence, the present study aimed to determine the effect of frequency and duration of tobacco use on oral mucosal lesions among tobacco users in Hyderabad city.

Physical activity among dental health professionals in Hyderabad City: A questionnaire survey.

Background: To assess and compare physical activity based on age, gender, marital status, education, and employment among dental health professionals in Hyderabad City, India.

Materials And Methods: A cross-sectional questionnaire study was conducted among dentists and they were personally interviewed by a single trained interviewer. The frequency (in days) and time (in minutes) spent in doing vigorous- and moderate-intensity activity in a typical week in three domains and sedentary behavior were assessed using 16-item Global Physical Activity Questionnaire.

Self-Reported Obstacles to Regular Dental Care among Information Technology Professionals.

Introduction: Good oral health is important for an individual as well as social well-being. Occupational stress and work exhaustion in Information Technology (IT) professionals may influence the oral health and oral health related quality of life.

Aim: To assess and compare self-reported obstacles for regular dental care and dental visits among IT professionals based on age, gender, dental insurance and working days per week.

Efficacy of commercially available chlorhexidine mouthrinses against specific oral microflora.

Context: This study evaluates the antimicrobial efficacy of commercially available chlorhexidine (CHX) mouthrinses of different concentrations.

Aims: To evaluate and compare the antimicrobial efficacy of commercially available CHX mouthrinses of different concentrations (0.2%, 0.

Knowledge, Attitude and Practice Regarding Organ Donation among Indian Dental Students.

Background: Of the overall 9.5 million deaths annually in India, nearly 100,000 are due to organ failure. To save and extend lives, organ donation and organ transplantation have become the only hope.

Oral health status and treatment need among institutionalized elderly in India.

Aim: To assess the oral health status and treatment needs among elderly people aged 60 years and above residing as inmates in the old age homes of Hyderabad and Secunderabad, Andhra Pradesh, India.

Settings And Design: A cross-sectional study was performed to determine the oral health status and treatment needs among elderly people.

Materials And Methods: In order to assess the oral health status and treatment needs, the clinical assessment of oral mucosa, community periodontal index, loss of attachment, dentition status and treatment need, prosthetic status and prosthetic need was recorded based on a modified World Health Organization 1997 proforma.

Antimicrobial Efficacy of Ten Commercially Available Herbal Dentifrices against Specific Oral Microflora - In Vitro Study.

Aim: To determine and compare the antimicrobial efficacy of ten commercially available herbal dentifrices against specific strains of oral microflora using a standard diffusion method at full strength and 1:1 dilution at 24 h.

Materials And Methods: The standard strains of Streptococcus. mutans (ATCC 21293), Streptococcus sangius (MTCC 442), Actinomyces viscosus (ATCC 3268), Staphylococcus aureus (ATCC 2592), Streptococcus pyogenes (MTCC 442) and Candida albicans (ATCC 183) were obtained.

Knowledge, Attitude and Practice Regarding Tobacco Cessation Among Indian Dentists.

Purpose: To assess the knowledge, attitude and practice regarding tobacco cessation among dentists in Hyderabad city, India.

Materials And Methods: A cross-sectional questionnaire study was conducted among 264 dentists registered in the local Indian Dental Association branch, Hyderabad, Andhra Pradesh, India. The questionnaire comprised of 35 items and used a five-point Likert scale to assess tobacco use prevention and cessation counseling.

Awareness of basic life support among staff and students in a dental school.

Aim: To assess and compare the knowledge of basic life support (BLS) among third, fourth and fifth (III, IV and V) year Bachelor of Dental Surgery (BDS) clinical students, dental interns, postgraduate students and Bachelor of Dental Surgery (BDS) and Master of Dental Surgery (MDS) faculty of Panineeya Institute of Dental Sciences and Hospital, Hyderabad, India.

Materials And Methods: A BLS questionnaire consisting of 22 questions was used to assess the levels of III, IV and V years BDS clinical students, dental interns, postgraduate students and BDS and MDS faculty of Panineeya Institute of Dental Sciences and Hospital, Hyderabad, India. Statistical Package for Social Sciences software (SPSS version 12.

Oral cancer awareness and knowledge among dental patients in South India.

Aim: To assess the 1) levels of awareness and knowledge about risk factors and early signs of oral cancer among dental patients visiting dental hospital in Hyderabad city, South India 2) and to correlate the knowledge levels according to age, gender and education levels.

Methods: The survey comprised of 16-item questionnaire which was distributed to patients attending Panineeya Institute of Dental Sciences, Hyderabad. Data was collected and statistically analysis was done using SPSS software (12.

Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells.

Ulcerative colitis (UC) and Crohn's disease (CD) are common inflammatory bowel diseases producing intestinal inflammation and tissue damage. Although emerging evidence suggests these diseases are distinct, approximately 10% of patients remain classified as indeterminate inflammatory bowel disease even after invasive colonoscopy intended for diagnosis. A molecular diagnostic assay using a clinically accessible tissue would greatly assist in the classification of these diseases.

Exploiting genotypic differences to identify genes important for EAE development.

Experimental autoimmune encephalomyelitis (EAE) is an animal model of the human autoimmune disease multiple sclerosis (MS) and is primarily driven by T helper type 1 (Th1) cells. Interleukin (IL)-12 and interferon (IFN)-gamma are important cytokines involved in the differentiation and amplification of Th1 cells, however mice deficient in either IFN-gamma or IL-12 still develop EAE. We have used microarray analysis of EAE-affected CNS tissues in wild-type, IFN-gamma -/- and IL-12 -/- animals to identify genes critical for development of EAE.