A novel germline mutation, IVS4+1G>A, of the POU1F1 gene underlying combined pituitary hormone deficiency.

Background: POU1F1 is a pituitary transcription factor that plays a pivotal role in pituitary development and expression of the GH, PRL and TSH beta genes. Therefore, abnormalities of the POU1F1 gene are known to be responsible for a phenotype causing combined pituitary hormone deficiency (CPHD) involving growth hormone, prolactin and thyrotropin.

Methods: We described an 18-year-old Thai man, from a consanguineous family, who presented with short stature and cognitive deficit.

Adrenal hemorrhage as the first presentation of hepatocellular carcinoma.

We report a 67-year-old man who presented with sudden onset of pain in the left flank in association with anemia and hypotension. Imaging studies revealed hepatocellular carcinoma (HCC) at the right lobe of the liver with bilateral adrenal metastases and recent hemorrhage in the left adrenal gland. His serology for hepatitis C was positive.

Asymptomatic bilateral giant adrenal myelolipomas: case report and review of literature.

Objective: To describe an unusual case of bilateral giant adrenal masses caused by a primary adrenal myelolipoma.

Methods: We present the clinical, laboratory, and pathologic findings in a 32-year-old man with bilateral adrenal masses. The previous reports of bilateral myelolipomas also were reviewed.