Systemic T Cell Subsets and Cytokines in Patients With Homozygous Sickle Cell Disease and Asymptomatic Urinary Tract Infections in Togo.

In sickle cell disease (SCD), cytokine expression influences the pivotal pathways that contribute to disease pathogenesis. Additional infection could affect the immune profile of patients with SCD and increase disease mortality. The aim of this study was to investigate the cytokines and T helper cells profile in patients with asymptomatic urinary tract infection and homozygous SCD (HbSS).

[Anemia in blood donors and criteria of hemoglobin level control at the national blood transfusion center (NBTC) of Lomé, Togo].

Introduction: The aim of this study was to evaluate the prevalence of anemia among blood donors at Lomé national blood transfusion center (NBTC) and to identify criteria for controlling hemoglobin level in blood donation candidates.

Methods: We determined the hemoglobin level using HemoCue® 201+. To identify the hemoglobin level control criteria, the judgment parameters were the proportion of anemic donors based on the number of blood donations in the last 12 months and the staining of the conjunctiva.

[Characteristics of chronic lymphocytic leukemia in Togo].

The epidemiological, clinical and biological characteristics of chronic lymphocytic leukemia (CLL) are little studied in Togo. The purpose of this study was to describe these characteristics at the time of diagnosis. We conducted a retrospective and descriptive study of patients diagnosed at the University Hospital Campus from January 1999 to December 2018.

[Quality control of red blood cell pockets produced at Centre National de Transfusion Sanguine de Lomé].

Introduction: at the National Center for Blood Transfusion (NCBT) in Lomé, whole blood is systematically separated into its various labile blood products. This study aims to assess the quality of the red blood cell concentrates (RBCC) produced.

Methods: we conducted a cross-sectional study on 260 RBCCs (204 adult units and 56 paediatric units) from January to March 2018.

Intrauterine Growth Retardation Complicated by Biermer's Disease: An Observation in Togo.

Objective: To report the first case in Togo of Biermer's disease associated with intrauterine growth retardation (IUGR) in a 39-year-old pregnant woman.

Observation: The patient with phenotype AA, born on 20/02/1978, GP (a spontaneous abortion at 3 months), was referred to hematology on 17 March 2017 for anemia at 26 weeks of amenorrhea (WA). She had received martial treatment with ferrous fumarate 66 milligrams daily.

Therapeutic phlebotomy during major sickle cell disease in Togo.

To determine the influence of therapeutic phlebotomy on the reduction of vaso-occlusive crises (VOCs) and of hospital admissions of patients with sickle cell disease and to describe how they experience this practice. Descriptive cross-sectional study of 27 patients with sickle cell disease who underwent phlebotomies. We estimated the number of VOCs, hemoglobin levels, and patient response.

[Prevalence of albuminuria in sickle cell disease patients at the Campus university hospital of Lome, Togo].

Objectives: The objective of this study was to assess the prevalence of albuminuria in sickle cell disease patients at the Campus University Hospital of Lome.

Patients And Method: Albuminuria was assessed by the urinary albumin-to-creatinine ratio (UACR) in sickle cell disease individuals who attended the outpatient consultation in their steady state.

Results: The prevalence of albuminuria was 21% (14/67).

[Types of bcr-abl and their correlations with the blood count in chronic myeloid leukemia (CML) in Togo].

This study aims to describe the different bcr-abl gene transcript variants in order to determine their frequency and to study their influence on CBC diagnostic test. We conducted a cross-sectional study of 34 patients with chronic myeloid leukemia in Togo. The search for fusion transcripts was performed in the laboratory of biological haematology at the Henri Mondor Hospital, Créteil (France).

[Biermer's disease in the hematology service of campus teaching hospital of Lomé: 13 cases from January 2013 to December 2014].

Aims: To study the epidemiological, clinical, paraclinical and therapeutic aspects of Biermer's disease in the hematology service of campus teaching hospital of Lomé.

Method: This retrospective study was conducted in the laboratory service of the University Hospital campus in which there is a unit of clinical hematology. This study took place over a period of twelve years and has identified 13 patients (5 men, 8women).

Evaluation of the Histo-Epidemiological Profile of Solid Childhood Cancers in Togo.

Background: Cancer is a subject of continuing concern, more common in adults than in children, but often with a poor outcome in the latter. Our study set itself the objective to describe the epidemiological and histological aspects of solid cancers in children in Togo.

Materials And Methods: This descriptive, cross-sectional study focused on cases of solid cancers in children diagnosed from 2010 to 2014 (5 years) at the pathology laboratory of the Tokoin teaching hospital.

[Rare hemoglobins in Togo: a 15-year study at the Lomé University Campus Hospital Center].

Objectives: To identify the rare hemoglobins (Hbs) encountered in Togo and characterize their geographical and ethnic distribution and hematologic expression.

Material And Method: This retrospective descriptive study covers 27,530 hemoglobin electrophoresis tests performed in the department of Hematology of the Lomé Campus teaching hospital from January 1996 through December 2010, the national reference laboratory. The anomalies identified were studied with both alkaline and acid electrophoresis and high performance liquid chromatography (HPLC), all performed in Lome.

[Chronic myeloid leukemia and imatinib: Experience at the Lome Campus teaching hospital (Togo)].

Background: Chronic myeloid leukemia (CML) is a clonal malignant myeloproliferative disorder characterized by the expansion of hematopoietic cells carrying the Philadelphia chromosome (t 9.22). Our main objective was to assess the efficacy of imatinib in CML patients, measured by their survival.

[Myeloproliferative disorders "Philadelphia negative" and JAK2V617F mutation: study of 15 cases in Togo].

The goal of our study is to document the prevalence of change JAK2V617F among patients reached of myeloproliferative syndromes (MPS) in Togo in order to evaluate frequencies. This descriptive study included 15 patients followed with the CHU Campus for a SMP. The research of JAK2 change by PCR was carried out with the APHP Henri Mondor of Creteil (France).

Cancers in togo from 1984 to 2008: epidemiological and pathological aspects of 5251 cases.

Objective. To describe the epidemiological and histological aspects of cancers in Togo. Materials and Methods.

[Evaluation of the Widal-Felix serodiagnostic test in Togo].

Purpose: To evaluate the efficacy of Widal-Felix serodiagnostic testing in Togo.

Method: This study using a cohort of 200 patients recruited at hospitals in Lome and Atakpame from November 2005 to April 2006 was designed to compare the sensitivity and specificity of the routinely used technique (plate agglutination) and reference technique (tube agglutination).

Results: Findings showed that the prevalence of typhoid fever was 1.