Preparation and Characterization of Quartz-Reinforced Hybrid Composites Based on Unsaturated Polyester Resin from Post-Consumer PET Recyclate.

The paper presents the results of research on hybrid composites made of unsaturated polyester resin based on post-consumer recycled poly(ethylene terephthalate). The polymeric materials were reinforced with quartz flour, which is a common inorganic mineral filler. An environmentally friendly cobalt polymer solution was used to cure the polyester matrix.

The Influence of Carbon Nanotubes on the Physical and Chemical Properties of Nanocomposites Based on Unsaturated Polyester Resin.

The new actual scientific direction is in the development of different nanocomposites and the study of their medical-biological, physicochemical, and physicomechanical properties. One way to expand the functionality of nanocomposites and nanomaterials is to introduce carbon nanostructures into the polymer matrix. This study presents the properties of unsaturated polyester resins (Estromal, LERG S.

Properties of Eco-Friendly Composites Based on Post-Consumer Recycled Resin Filled with Walnut Shell Powder.

Increased demand for environmentally friendly materials resulted in a worldwide interest in manufacturing composite materials from agricultural wastes. Thus, this paper presents the results of research on the synthesis of eco-friendly composites and their properties. For their preparation, unsaturated polyester resin based on post-consumer recycled poly (ethylene terephthalate) was filled with walnut ( L.

Assessment Study on the Solvent Resistance of Low-Density Polyethylene with Pumpkin Seed Hulls.

When designing products that are made of composite materials and that contain natural fillers, it is particularly important to consider the long-term exposure of these materials to caustic liquids and substances (concentrated acids, bases), and to ensure that these products meet strict requirements for reliability and operational safety. This study investigated the effects of different solvents on the mass, mechanical, thermal, surface, and structural properties of polymer composites containing natural fillers in the form of pumpkin seed hulls. Experiments were conducted using four different filler contents (5, 10, 15, and 20 wt%) and grain sizes ranging from 0.

Study on the Properties and Structure of Rotationally Moulded Linear Low-Density Polyethylene Filled with Quartz Flour.

The objective of this study is to determine selected properties of thin-walled rotationally moulded composite parts. Linear low-density polyethylene (LLDPE) filled with quartz flour (QF, 5-35 wt.%) was tested.

Investigation of Degradation of Composites Based on Unsaturated Polyester Resin and Vinyl Ester Resin.

This study compares the degradation process of unsaturated polyester resin (UPR) and vinyl ester resin (VER) and their biocomposites with kraft lignin. In order to study their degradation, accelerated aging, immersion in different solvents, microwave radiation and high temperature were applied. The results show that, depending on the conditions, the degradation assumes a different course.

Effect of Eco-Friendly Peanut Shell Powder on the Chemical Resistance, Physical, Thermal, and Thermomechanical Properties of Unsaturated Polyester Resin Composites.

The paper investigates the synthesis of eco-friendly composites and their properties before and after immersion in solvents of different chemical natures. For their preparation, unsaturated polyester resin (UPR) based on recycled poly (ethylene terephthalate) (PET) and peanut shell powder (PSP) were used. Polymerization was carried out in the presence of environmentally friendly polymeric cobalt.

Studies on Preparation, Characterization and Application of Porous Functionalized Glycidyl Methacrylate-Based Microspheres.

A one-step swelling and polymerization technique was used in the synthesis of porous glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) monodisperse polymeric microspheres. The polystyrene (PS) seed obtained in the dispersion polymerization was used as a shape template. The presence of epoxide rings in the chemical structure of microspheres enables their post-polymerization chemical modifications involving: the Diels-Alder reaction with sodium cyclopentadienide and maleic anhydride, the reaction with 4,4'-(bismaleimido)diphenylmethane, and the thiol-Michael reaction with methacryloyl chloride and 2-mercaptopropionic acid.

Synthesis, Characterization and Testing of Antimicrobial Activity of Composites of Unsaturated Polyester Resins with Wood Flour and Silver Nanoparticles.

This paper presents the properties of the wood-resin composites. For improving their antibacterial character, silver nanoparticles were incorporated into their structures. The properties of the obtained materials were analyzed in vitro for their anti-biofilm potency in contact with aerobic Gram-positive and ; and aerobic Gram-negative and .

Green Composites Based on Unsaturated Polyester Resin from Recycled Poly(Ethylene Terephthalate) with Wood Flour as Filler-Synthesis, Characterization and Aging Effect.

The paper investigates the synthesis of green composites and their properties before and after the laboratory accelerated aging tests. Materials were made of unsaturated polyester resins (UPRs) based on recycled poly(ethylene terephthalate) (PET) and wood flour (WF). The effect of dibenzylideneacetone (dba) addition on mechanical and thermomechanical properties was also determined.

Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141 Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8 T Cell Response in Human Immune System Mice.

Active co-delivery of tumor antigens (Ag) and α-galactosylceramide (α-GalCer), a potent agonist for invariant Natural Killer T (NKT) cells, to cross-priming CD8α dendritic cells (DCs) was previously shown to promote strong anti-tumor responses in mice. Here, we designed a nanoparticle-based vaccine able to target human CD141 (BDCA3) DCs - the equivalent of murine CD8α DCs - and deliver both tumor Ag (Melan A) and α-GalCer. This nanovaccine was inoculated into humanized mice that mimic the human immune system (HIS) and possess functional NKT cells and CD8 T cells, called HIS-CD8/NKT mice.

Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.

Background: COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients.

Case Presentation: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home.

Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.

Background: COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients.

Case Presentation: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home.

Advanced Cell Mapping Visualizations for Single Cell Functional Proteomics Enabling Patient Stratification.

Highly multiplexed single-cell functional proteomics has emerged as one of the next-generation toolkits for a deeper understanding of functional heterogeneity in cell. Different from the conventional population-based bulk and single-cell RNA-Seq assays, the microchip-based proteomics at the single-cell resolution enables a unique identification of highly polyfunctional cell subsets that co-secrete many proteins from live single cells and most importantly correlate with patient response to a therapy. The 32-plex IsoCode chip technology has defined a polyfunctional strength index (PSI) of pre-infusion anti-CD19 chimeric antigen receptor (CAR)-T products, that is significantly associated with patient response to the CAR-T cell therapy.

Composites of Unsaturated Polyester Resins with Microcrystalline Cellulose and Its Derivatives.

The paper investigates the properties of unsaturated polyester resins and microcrystalline cellulose (MCC) composites. The influence of MCC modification on mechanical, thermomechanical, and thermal properties of obtained materials was discussed. In order to reduce the hydrophilic character of the MCC surface, it was subjected to esterification with the methacrylic anhydride.

Single-Cell Multiplexed Proteomics on the IsoLight Resolves Cellular Functional Heterogeneity to Reveal Clinical Responses of Cancer Patients to Immunotherapies.

Cancer immunotherapies, in particular adoptive T cell therapy and immune-checkpoint blockade therapy have demonstrated a remarkable success in the treatment of cancer. However, due to heterogeneous functionality and complex immune response of immune cells, it remains challenging to identify predictive biomarkers which have the potential to correlate with efficacy and adverse effects of immunotherapies and help selecting patients who might benefit from the therapy, developing more personalized therapeutics as well as reducing clinical trial cost. The single-cell IsoCode chip in conjunction with fluorescent ELISA-based assay enables a simultaneous detection up to 40+ proteins secreted from live single immune cells, providing a large portion of the assayable functions for each immune cell type, and thus precise assessment of multifunctional, or polyfunctional, heterogeneity of each immune cell type.

Investigation of accelerated aging of lignin-containing polymer materials.

This paper presents the results of an accelerated aging test of biocomposites containing kraft lignin, where the resistance of the materials against humidity and light exposure was investigated. Low molecular weight lignin, modified with methacrylic anhydride (LWL-Met), was copolymerized with two commercial monomers: styrene (St) and methyl methacrylate (MMA). The biocomposites were obtained by a bulk polymerization method using α,α'-azoiso-bis-butyronitrile (AIBN) as a free radical polymerization initiator.

Enhanced TLR2 responses in multiple sclerosis.

The roles of the microbiome and innate immunity in the pathogenesis of multiple sclerosis (MS) remain unclear. We have previously documented abnormally low levels of a microbiome-derived Toll-like receptor (TLR)2-stimulating bacterial lipid in the blood of MS patients and postulated that this is indicative of a deficiency in the innate immune regulating function of the microbiome in MS. We postulated further that the resulting enhanced TLR2 responsiveness plays a critical role in the pathogenesis of MS.

PaperCraft3D: Paper-Based 3D Modeling and Scene Fabrication.

A 3D modeling system with all-inclusive functionality is too demanding for a casual 3D modeler to learn. There has been a shift towards more approachable systems, with easy-to-learn, intuitive interfaces. However, most modeling systems still employ mouse and keyboard interfaces, despite the ubiquity of tablet devices and the benefits of multi-touch interfaces.

Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL.

After treatment with chimeric antigen receptor (CAR) T cells, interleukin-15 (IL-15) elevation and CAR T-cell expansion are associated with non-Hodgkin lymphoma (NHL) outcomes. However, the association of preinfusion CAR product T-cell functionality with clinical outcomes has not been reported. A single-cell analysis of the preinfusion CD19 CAR product from patients with NHL demonstrated that CAR products contain polyfunctional T-cell subsets capable of deploying multiple immune programs represented by cytokines and chemokines, including interferon-γ, IL-17A, IL-8, and macrophage inflammatory protein 1α.

Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response.

Background: It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency and immunotoxicity ex vivo, despite promising in vivo efficacy in patients with B cell malignancies.

Methods: We employed a single-cell, 16-plex cytokine microfluidics device and new analysis techniques to evaluate the functional profile of CD19 CAR-T cells upon antigen-specific stimulation. CAR-T cells were manufactured from human PBMCs transfected with the lentivirus encoding the CD19-BB-z transgene and expanded with anti-CD3/anti-CD28 coated beads.

Results of surgical treatment of cervical esophageal diverticula.

On the basis of 20 years' experience, the authors present the immediate and long-term results of operative treatment of Zenker's diverticulum. Comparison of two methods of surgery - diverticulopexia (in 21 patients) and excision (in 16), both associated with upper esophageal sphincter myotomy - shows good immediate and longterm results (from 1 to 19 years), with disappearance of symptoms (dysphagia) in all patients. There was no perioperative mortality.

CD8+ T-cell mediated anti-malaria protection induced by malaria vaccines; assessment of hepatic CD8+ T cells by SCBC assay.

Malaria is a severe infectious disease with relatively high mortality, thus having been a scourge of humanity. There are a few candidate malaria vaccines that have shown a protective efficacy in humans against malaria. One of the candidate human malaria vaccines, which is based on human malaria sporozoites and called PfSPZ Vaccine, has been shown to protect a significant proportion of vaccine recipients from getting malaria.

TEM studies of the nitrided/oxided Ni-Ti surface layer.

TiN and TiO(2) coatings, which are known from their low chemical reactivity, high hardness and wear and corrosion resistance, are used for protecting the NiTi surface. In the present work, nearly equiatomic NiTi (50.6 at.

The outcome of a bilateral leg amputation according to Syme;s technique as a result of posttraumatic complications: a case report.

Background. The purpose of this article is to present the problems encountered in treatment and rehabilitation, including prosthesis fitting, in the case of a 17-year-old female patient who underwent a bilateral leg amputation using Syme's method. Case history.