Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits.

The number of variants that have a non-zero effect on a trait (i.e. polygenicity) is a fundamental parameter in the study of the genetic architecture of a complex trait.

Oculocardiac Reflex During Intravitreal Injection.

Oculocardiac reflex (OCR) has been described to occur with mechanical manipulation of the eye, eyelids or orbit. There are no reports in the literature of OCR during intravitreal injection (IVI). This may be due to the fact that heart rate is not monitored during the procedure.

Derivation of a cost-saving screening strategy for asymptomatic primary hyperparathyroidism.

Background: Our study seeks to find a cost-saving screening strategy in a primary care population for diagnosing primary hyperparathyroidism based on peak serum total calcium level, age, and patient sex.

Methods: Laboratory data resulting from primary care office visits at our institution between January 2016 through December 2017 to evaluate patients who had at least 1 episode of hypercalcemia (≥10.5 mg/dL).

Acute angle-closure glaucoma after hyperopic laser in situ keratomileusis.

We report a case of acute angle-closure glaucoma 1 year after hyperopic laser in situ keratomileusis (LASIK). The glaucoma was resolved with laser iridotomy, and a prophylactic iridotomy was performed in the fellow eye. Corneal topography was performed 2, 5, and 18 weeks after the acute episode.

Oculocardiac reflex in sedated patients having laser in situ keratomileusis.

Purpose: To eliminate stress as a variable in assessing the frequency of the oculocardiac reflex during laser in situ keratomileusis (LASIK).

Setting: Merida Ophthalmological Hospital and Oftalmedica, Mexico City, Mexico.

Methods: A pulse oximeter registered the heart rate of 30 sedated patients having LASIK.

Oculocardiac reflex during laser in situ keratomileusis.

Purpose: To evaluate the occurrence of oculocardiac reflex during laser in situ keratomileusis (LASIK).

Setting: Merida Ophthalmological Hospital, Mexico City, Mexico.

Methods: This study included 20 patients who were given an electrocardiogram prior to, during, and after LASIK.