Multidimensional Assessment of Physical Function for People in Dialysis: The Rehabilitation in Hemodialysis Area Centro Toscana (REACT) Study.

Background: Physical performance is poorly addressed in dialysis patients, due to several clinical and organizational barriers. In this study we investigated the physical functional status of a cohort of dialysis patients, using a multidimensional assessment.

Methods: Four hundred and forty-six individuals from 8 hemodialysis centers (176 females), mean age 67.

Correction: Micheli et al. Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation. 2020, , 1819.

In the original publication [...

Exploring odontocete depredation rates in a pelagic longline fishery.

Several odontocete species depredate catch and bait from fishing gear, resulting in their bycatch and causing substantial economic costs. There are no known mitigation methods for odontocete depredation in pelagic longline fisheries that are effective, do not harm odontocetes and are commercially viable. Understanding odontocetes' depredation strategies can contribute to mitigating this human-wildlife conflict.

Ready for new waves: optimizing SARS-CoV-2 variants monitoring in pooled samples with droplet digital PCR.

Introduction: The declaration of the end of the Public Health Emergency for COVID-19 on May 11th, 2023, has shifted the global focus led by WHO and CDC towards monitoring the evolution of SARS-CoV-2. Augmenting these international endeavors with local initiatives becomes crucial to not only track the emergence of new variants but also to understand their spread. We present a cost-effective digital PCR-based pooled sample testing methodology tailored for early variant surveillance.

Morphological variations of the lung: Accessory fissures and lobes.

Anatomical variability in the human body is not as rare as was previously hypothesised. Indeed, as recently reviewed, the term 'norm' in anatomy can be considered an approximation. Thus, anatomical variations occur quite often, as largely demonstrated during non-invasive diagnosis, surgical intervention, or post mortem investigations.

Editorial Perspective: Adapting western psychological interventions for children and adolescents in LMICs: lessons from Nepal.

Nepal is a low-middle income country which is considered to be a collectivist culture and has a significant mental health treatment gap for young people. The dominant approach in the global mental health literature has been to import western treatments with varying degrees of cultural adaptation. We argue that this approach is at best cost-ineffective, and at worst harmful, particularly where young people receive interventions outside of their community.

Unintentional pediatric exposures to household cleaning products: a cross-sectional analysis of the National Poison Data System (2000-2015).

Background: Household cleaning products are the second most common cause of unintentional poisoning in children < 6 years old in the United States. The aim of this study is to characterize exposures to household cleaning substances in this age group from data collected from the Nation's Poison Control Centers.

Methods: This cross-sectional study analyzed all household cleaner calls classified as age < 6 years old made to the American Association of Poison Control Centers between January 1st 2000 and December 31th 2015.

Broad-spectrum neuroprotection exerted by DDD-028 in a mouse model of chemotherapy-induced neuropathy.

Neurotoxicity of chemotherapeutics involves peculiar alterations in the structure and function, including abnormal nerve signal transmission, of both the peripheral and central nervous system. The lack of effective pharmacological approaches to prevent chemotherapy-induced neurotoxicity necessitates the identification of innovative therapies. Recent evidence suggests that repeated treatment with the pentacyclic pyridoindole derivative DDD-028 can exert both pain-relieving and glial modulatory effects in mice with paclitaxel-induced neuropathy.

Accurate Multiscale Simulation of Frictional Interfaces by Quantum Mechanics/Green's Function Molecular Dynamics.

Understanding frictional phenomena is a fascinating fundamental problem with huge potential impact on energy saving. Such an understanding requires monitoring what happens at the sliding buried interface, which is almost inaccessible by experiments. Simulations represent powerful tools in this context, yet a methodological step forward is needed to fully capture the multiscale nature of the frictional phenomena.

Nidus Compacity Determined by Semi-Automated Segmentation is a Strong Quantitative Predictor of Brain Arterio-Venous Malformation Cure.

Background And Objective: A compact nidus is a well-known feature of good outcome after treatment in brain arteriovenous malformations (bAVM). This item, included in the "Supplementary AVM grading system" by Lawton, is subjectively evaluated on DSA. The present study aimed to assess whether quantitative nidus compacity along with other angio-architectural bAVM features were predictive of angiographic cure or the occurrence of procedure-related complications.

Seasonality of the Meridional Overturning Circulation in the subpolar North Atlantic.

Understanding the variability of the Atlantic Meridional Overturning Circulation is essential for better predictions of our changing climate. Here we present an updated time series (August 2014 to June 2020) from the Overturning in the Subpolar North Atlantic Program. The 6-year time series allows us to observe the seasonality of the subpolar overturning and meridional heat and freshwater transports.

Polylactic-Containing Hyperbranched Polymers through the CuAAC Polymerization of Aromatic AB Monomers.

We report on the synthesis and characterization of a novel class of hyperbranched polymers, in which a copper(I)-catalyzed alkyne azide cycloaddition (CuAAC) reaction (the prototypical "click" reaction) is used as the polymerization step. The AB monomers bear two azide functionalities and one alkyne functionality, which have been installed onto a 1,3,5 trisubstituted benzene aromatic skeleton. This synthesis has been optimized in terms of its purification strategies, with an eye on its scalability for the potential industrial applications of hyperbranched polymers as viscosity modifiers.

Direct Recycling of WC-Co Grinding Chip.

Grinding is a finishing process for high precision, high surface quality parts, and hard materials, including tool fabrication and sharpening. The recycling of grinding scraps, which often contain rare and costly materials such as tungsten carbide (WC-Co), has been established for decades. However, there is a growing need for more energy-efficient and environmentally friendly recycling processes.

Morphological and Functional Effects of Ultrasound on Blood-Brain Barrier Transitory Opening: An In Vitro Study on Rat Brain Endothelial Cells.

With the recent advances in medicine, human life expectancy is increasing; however, the extra years of life are not necessarily spent in good health or free from disability, resulting in a significantly higher incidence of age-associated pathologies. Among these disorders, neurodegenerative diseases have a significant impact. To this end, the presence of the protective blood-brain barrier (BBB) represents a formidable obstacle to the delivery of therapeutics.

Connecting in place: older adults' experience of online mindfulness therapy during the COVID-19 pandemic.

Background: the negative consequences of COVID-19 distancing measures on older adults' mental health and ability to access services have been well documented. Online cognitive behavioural therapy and mindfulness interventions for older adults, carried out during the COVID-19 pandemic, have shown that these interventions are feasible and have potential mental health benefits. However, little research has been carried out on older adults' experiences of engaging with online psychological therapy, and specifically mindfulness therapy.

Utilizing AI to unveil the nonlinear interplay of convection, drift, and diffusion on galactic cosmic ray modulation in the inner heliosphere.

Galactic Cosmic Rays (GCRs) are charged particles, originating from galactic and/or extra-galactic Supernova Remnants (SNR), that continuously permeate the Heliosphere. The GCRs are modulated in the heliosphere by convection by solar wind (SW), drift via gradients and curvatures in the Heliospheric Magnetic Field (HMF), diffusion from fluctuations in the HMF, and adiabatic cooling in the expanding SW. An improved understanding of their modulation is imperative as studies on the variations in solar activity levels and solar eruptions in the past rely heavily on the relationship between their modulation and formation of the secondary particles in the Earth's atmosphere.

Practical considerations to establish a validated platform for pooled detection of SARS-CoV-2 by droplet digital PCR.

Detection of SARS-CoV-2 has created an enormous workload for laboratories worldwide resulting in a restriction at the time of massive testing. Pool testing is a strategy that reduces time and costs. However, beyond the detection of infectious diseases in blood banks, this approach is rarely implemented in routine laboratories.