Amyloidosis is the pathologic extracellular deposition of amyloid, a proteinaceous substance, in various tissues and organs. The most common form of amyloidosis in domestic animals is amyloid A amyloidosis, though amyloid light chain, amyloid β, and islet amyloid polypeptide amyloidosis have been documented. In reptiles, amyloidosis, or amyloid-like disorders, are considered rare.
View Article and Find Full Text PDFAnts are a diverse and ecologically important group of social insects, playing a key role in ecosystem functioning. However, significant gaps remain in our understanding of their distribution across the Brazilian biomes. In this study, we surveyed four sites within a poorly sampled region of the Cerrado, located between Mato Grosso (MT) and Goiás (GO) states in Brazil.
View Article and Find Full Text PDFFusarium wilt is a devastating disease that affects banana crops worldwide. In Ecuador, bananas are one of the most important commodities and staple food. Nanoparticles are emerging as innovative solutions to control fungal diseases in plant protection.
View Article and Find Full Text PDFPrimary adenocarcinoma of the urinary bladder is a rare malignancy, comprising up to 2% of bladder cancers, predominantly in males. Its rarity and similarity to urothelial carcinoma and secondary adenocarcinomas pose diagnostic challenges. A comprehensive literature review was conducted on the diagnosis, classification, morphological and immunophenotypic characteristics, and molecular profiles of primary adenocarcinoma, urachal adenocarcinoma, and precursor lesions.
View Article and Find Full Text PDFGiant cell tumours (GCTs) of the larynx are extremely rare. The most affected structure is the thyroid cartilage and only 44 cases are reported in the literature. Clinically, their first manifestation is usually a palpable neck mass, often accompanied by hoarseness, dyspnoea, and/or dysphagia depending on size and location.
View Article and Find Full Text PDFBased on the eighth edition of the American Joint Committee on Cancer staging system, postpubertal germ cell tumors (GCT) and malignant sex cord-stromal tumors (SCST) of the testis invading hilar soft tissue are of pathologic stage pT2. Adipose tissue is typically used as an anatomical landmark by pathologists for determining hilar soft tissue invasion. Herein, we evaluated for the presence, location, and extent of intratesticular fat in a multi-institutional cohort of orchiectomies.
View Article and Find Full Text PDFMycobacterium leprae (M. leprae) is a globally distributed intracellular pathogen that causes human leprosy. For many years, M.
View Article and Find Full Text PDFGamna-Gandy (GG) bodies are sclerosiderotic nodules composed of iron pigment and calcium, that have been described predominantly in the spleens of patients with sickle cell disease. Their formal depiction in the kidney is mainly limited to case reports and small series. We aimed to investigate the incidence of GG bodies and associated clinicopathologic features in consecutive nephrectomies performed for renal tumors.
View Article and Find Full Text PDFIntroduction: Breast cancer-related lymphedema (BCRL) is a complication that requires lifelong control, with patients taking responsibility for self-care. Mobile applications (apps) can be an effective health education strategy to help manage BCRL by promoting collaborative learning environments in physical therapy. The objective of this study was to design and validate the content for the development of a mobile application for self-care in the health of the BCRL.
View Article and Find Full Text PDFObjective: The objective of this study was to describe and critically appraise the conclusions of randomized clinical trials assessing monoclonal antibodies sponsored by the pharmaceutical industry.
Methods: This is a meta-research study on conclusions' characteristics of randomized clinical trials with monoclonal antibodies as interventions sponsored by the pharmaceutical industry.
Results: A total of 82 publications were considered.
Background And Objective: In recent years, the consumption of fish products has led to a worrying trend where approximately two-thirds of the total amount of fish is discarded as waste. At the same time, scientific interest in exploring natural collagen sources for cosmetics and dietary supplements has increased. This study explores the potential of valorizing sardine scales (), a by-product of the canning industry, through the extraction of collagen for potential use in dermocosmetic formulations and food supplements.
View Article and Find Full Text PDFNon-carious cervical lesions (NCCLs) become common in individuals over the age of 40 and are progressive. Those that are wedge-shaped in cross-section likely develop hazardous stress concentrations along their sharp axial extent, which can be distributed to lower, safer levels over a larger area via adhesive restoration. Restoration is indicated once a lesion progresses to a minimum restorable axial depth of at least 1.
View Article and Find Full Text PDFObjectives: This study aimed to evaluate the impact of battery levels on the emission of a multi-peak cordless LED light-curing unit (LCU) and the effect on the degree of conversion (DC) and Knoop hardness (KH) of a light-cure resin luting agent activated through varying lithium disilicate (LiS2) ceramic thicknesses and translucencies.
Methods: High and low translucency LiS2 discs (IPS e.max Press HT and LT, respectively; shade A1) with thickness of 0.
Background: Advanced cell therapies emerged as promising candidates for treatment of knee articular diseases, but robust evidence regarding their clinical applicability is still lacking.
Objective: To assess the efficacy and safety of advanced mesenchymal stromal cells (MSC) therapy for knee osteoarthritis (OA) and chondral lesions.
Methods: Systematic review of randomized controlled trials conducted in accordance with Cochrane Handbook and reported following PRISMA checklist.
Int J Mol Sci
September 2024
Inflammatory bowel diseases (IBDs) involve chronic inflammation of the gastrointestinal tract, where effector CD4 T-cells play a central role. Thereby, the recruitment of T-cells into the colonic mucosa represents a key process in IBD. We recently found that CCR9 and DRD5 might form a heteromeric complex on the T-cell surface.
View Article and Find Full Text PDFJ Eval Clin Pract
September 2024
Objective: To evaluate the methodological and reporting quality of systematic reviews (SR) of randomized controlled trials on esthetics and reconstructive breast surgery.
Methods: Meta-research study with a broad search strategy was developed to retrieve all relevant systematic reviews. We evaluated the methodological and reporting guidance adopted by these reviews and assessed their adequacy to items from AMSTAR-2 (methodological quality) and PRISMA 2020 (reporting quality).
The purpose of this study was to introduce a novel and simple method of evaluating the crystal length and crystalline content of lithium disilicate dental ceramics using images obtained from scanning electron microscopy (SEM) and analyzed with ImageJ (NIH) processing software. Three evaluators with varying experience levels assessed the average crystal length and percentage of crystalline content in four commercial lithium disilicate reinforced glass ceramic materials: IPS e.max (Ivoclar Vivadent), Rosetta SM (Hass), T-Lithium (Talmax), and IRIS CAD (Tianjin).
View Article and Find Full Text PDFIntroduction. Proper management of multidrug-resistant tuberculosis is a prioritized strategy for tuberculosis control worldwide. Objective.
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