Phenotypic and Genotypic Profiles of Extended-Spectrum Beta-Lactamase-Producing Multidrug-Resistant in Northeastern Thailand.

The global emergence of extended-spectrum beta-lactamase (ESBL)-producing presents a significant public health threat and complicates antibiotic treatment for infections. This study aimed to determine the prevalence of ESBL-producing in a clinical setting, analyze their antimicrobial susceptibility profiles, and characterize both phenotypic and genetic determinants. A total of 507 non-duplicate clinical isolates of were collected between 2019 and 2020, and third-generation cephalosporin resistance was screened by disk diffusion.

High prevalence of ESBL-producing E. coli phylogroup B2 clinical isolates in northeastern Thailand.

Background: Production of extended-spectrum β-lactamases (ESBLs) is a common resistance mechanism in Enterobacteriaceae, leading to serious hospital-acquired infections. This study aimed to assess phenotypic, phylogenetic, and antibiotic resistance patterns among ESBL-producing Escherichia coli isolates recovered from two rural tertiary hospitals in Thailand.

Results: Among 467 Enterobacteriaceae isolates, E.