Development of a recombinant human IgG1 monoclonal antibody against the TRBV5-1 segment of the T cell receptor for the treatment of mature T cell neoplasms.

Background: Mature T-cell neoplasms arise from the neoplastic transformation of a single T lymphocyte, and all cells in a neoplastic clone share the same V segment in the beta chain of the T-cell receptor (TCR). These segments may represent an innovative target for the development of targeted therapies.

Methods: A specific V segment of the TCR beta chain (TRBV5-1) was analyzed using bioinformatic tools, identifying three potential antigenic peptides.

A Protocol for a Mixed Methods, Single-Arm, Hybrid Effectiveness-Implementation Trial Evaluating a 12-week Yoga Intervention Delivered by Videoconference for Young Adults Diagnosed With Cancer.

Background: Cancer among young adults (18-39 years) is relatively rare, but remains a leading cause of disability, morbidity, and mortality. Identifying strategies to support young adults' health following a diagnosis of cancer is important. Yoga may enhance health and could be delivered by videoconference.

An outlook on structural biology after AlphaFold: tools, limits and perspectives.

AlphaFold and similar groundbreaking, AI-based tools, have revolutionized the field of structural bioinformatics, with their remarkable accuracy in ab-initio protein structure prediction. This success has catalyzed the development of new software and pipelines aimed at incorporating AlphaFold's predictions, often focusing on addressing the algorithm's remaining challenges. Here, we present the current landscape of structural bioinformatics shaped by AlphaFold, and discuss how the field is dynamically responding to this revolution, with new software, methods, and pipelines.

Rapid nuclear deadenylation of mammalian messenger RNA.

Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm. Here, we combined long-read sequencing with metabolic labeling, splicing inhibition and cell fractionation experiments to quantify, separately, the genesis and trimming of nuclear and cytoplasmic tails and .

A Pilot Study on an Integrated Service Based on Wearable Textile Platforms to promote Workers Wellness at Workplace.

This paper describes a study performed in the frame of Wearables project and reports preliminary results. Objective of the study was the implementation of an integrated service finalized to increase employees' well-being through the investigation on the correlation between daily working activity and the observed physical parameters. The project monitored 28 volunteers employed in the field of waste collection (at the Amey's contract with Wolverhampton City Council), for a total of 275 data acquisition sessions.

An Ecological Studybased on Textile Sensory Platforms to Improve Safety and Well-Being at Work.

This paper describes a study performed in the frame of WEARABLES project and reports about preliminary analysis of the results on the activity, HR and breathing rate distribution. Objective of the study was the monitoring of employees' well-being finalized at the investigation on the correlation between daily working activity and the observed physical parameters. The study has been performed by using sensing textiles, to collect objective work-correlated parameters during daily activity aiming at the acquisition of objective indicators for an improved management of people within teams.

Incidence and distribution of coeliac disease in Campania (Italy): 2011-2013.

Background: There exists a wide variation in the reported incidence of coeliac disease in recent decades. We aimed to evaluate the incidence rate of coeliac diagnoses performed in an Italian region, Campania, between 2011 and 2013 and its variation therein.

Methods: All coeliac diagnoses made from 2011 to 2013 and registered within the Campania coeliac disease register (CeliacDB) were identified.

Trapeziometacarpal arthrodesis: is bone union necessary for a good outcome?

We present a retrospective study of 107 cases of thumb carpometacarpl joint arthrodesis. The aim of our study was to analyse our population and to compare the outcomes of patients who obtained bone union with the patients who did not. There were no statistical differences in most of the clinical outcomes (DASH score, visual analogue scale, Kapandji test, grip, and key pinch) between the two groups of patients; there were fewer cases of scaphotrapeziotrapezoid arthritis in the group that did not obtain bone union.

New generation of wearable goniometers for motion capture systems.

Background: Monitoring joint angles through wearable systems enables human posture and gesture to be reconstructed as a support for physical rehabilitation both in clinics and at the patient's home. A new generation of wearable goniometers based on knitted piezoresistive fabric (KPF) technology is presented.

Methods: KPF single-and double-layer devices were designed and characterized under stretching and bending to work as strain sensors and goniometers.

Subclinical atherosclerosis in systemic lupus erythematosus and antiphospholipid syndrome: focus on β2GPI-specific T cell response.

Objective: Systemic Lupus Erythematosus (SLE) and antiphospholipid syndrome (APS) are associated with a high prevalence of atherosclerosis. β2 glycoprotein I (β2GPI) represents a link between autoimmunity and endothelial dysfunction. Recently, β2GPI reactive T cells have been identified; however, their role in atherosclerosis is still under investigation.

Performances evaluation of piezoresistive fabric sensors as function of yarn structure.

This work focus on the characterization of piezoresistive fabric sensors, realized with conductive yarns that are similar in term of conductive components, but different only in term of geometry, the yarns have been realized according two different production processes while the sensors have been produced following the same process, fabric structure and same materials. The different geometry of the yarns affects dramatically conductivity and functionality of the sensors in term of sensitivity and hysteresis minimization. This result confirms that the functional components can be engineered during the different phases of the process production; to get new properties and new applications.

Textile electrodes and integrated smart textile for reliable biomonitoring.

Since birth the first and the most natural interface for the body is fabric, a soft, warm and reassuring material. Cloth is usually covering more than 80 % of the skin; which leads us to consider textile material as the most appropriate interface where new sensorial and interactive functions can be implemented. The new generation of personalised monitoring systems is based on this paradigm: functions like sensing, transmission and elaboration are implementable in the materials through the textile technology.

E-Textile platforms for rehabilitation.

This paper focus on SFIT platforms for rehabilitations and FES therapy. Two systems will be described, one developed to support patients during motor therapy, when they are still hospitalized, and after discharge, at home; the other is a sleeve integrating multi-electrodes patches, designed to allow FES therapy and EMG acquisition for patients affected by tremor. These examples prove that it is possible to combine fabric electrodes and biomechanical textile sensors to conceive systems where gesture recognition function can be combined with EMG detection and FES capability.

[Lifestyle and global cardiovascular risk: a prospective study on a borderline hypertensive population].

Background And Aims: Arterial hypertension is a well known risk factor for cardiovascular diseases. Today, it is possible to calculate the cardiovascular risk at 10 years with the risk card. The reduction of cardiovascular risk is based on a multi-factorial approach including the lifestyle modification.

Wearable monitoring system for chronic cardio-respiratory diseases.

In this paper is presented the study leading to the implementation of an innovative sensing textile platform, based on a wearable monitoring system named Wealthy, where novel piezoresistive sensors have been integrated to increase system capability in the field of pulmonary and cardiovascular diseases monitoring. Two different typologies of textile sensors for plethysmograpic measurements have been characterized and compared to evaluate sensors performance, through electro-dynamic laboratory tests and in vivo measurements. The whole system allows continuous remote monitoring of electrocardiogram and impedance pneumography signals through textile electrodes, while piezoresistive fabric sensors placed at the abdominal and thoracic level are able to discriminate between different breathing patterns.

Textile piezoresistive sensors for biomechanical variables monitoring.

In this paper is described the study leading to the implementation of two novel classes of textile piezoresistive sensors, for application in the field of post stroke rehabilitation and cardiovascular diseases monitoring. Two different approaches have been used, the first one leading to the realization of knitted transducer fabric to be integrated in bio-clothes for motion activity and respiration monitoring through plethysmography, the other one leading to printed sensing clothes for movement and posture detection. In particular, this work focuses on the optimization of sensors performances in term of sensing properties with the final objective to go towards a mass production.

Triple (interferon, ribavirin, amantadine) versus double (interferon, ribavirin) re-therapy for interferon relapser genotype 1b HCV chronic active hepatitis patients.

BACKGROUND: Retreatment for 6 months with the association ribavirin-interferon of HCV-related chronic active hepatitis relapser patients has high probability of failure, mostly in those with genotype 1b. We evaluated the efficacy of extending the therapy from 6 to 12 months without or with the addition of amantadine. METHODS: Forty-nine genotype 1b relapser patients were treated with 3 MU of IFN-alpha2b three times per week and ribavirin 1000-1200 mg daily (double therapy).

[Delayed diagnosis: inevitable fatality or wrong methodological approach? Churg-Strauss syndrome].

A case of CSS is reviewed, along its difficult diagnosis, to check if its late discovery is attributed to inevitability or to erroneous approach.

Characterization of organic osmolytes in avian renal medulla: a nonurea osmotic gradient system.

We measured the organic osmolytes present in the renal cortex and medullary cones of adult female domestic fowl before and after 48 h of water deprivation. Urine osmolality increased from 198 +/- 82 to 569 +/- 42 mosmol/kgH2O after water deprivation. In water-deprived birds, the major organic osmolytes, myoinositol, betaine, and taurine, in the medullary cones increased by 40, 100, and 24%, respectively, compared with control birds.

Cardiovascular effects induced by progesterone administration.

The Authors have studied cardiovascular effects induced by progesterone administration. The results obtained in the present investigation reveal a significant reduction in O-S2 and PEP in the absence of modifications in the values of the other parameters of systolic time intervals. The results confirm the hypothesis that progesterone exerts an adrenergic effect upon cardiac function.