Comparative analysis of fetal dose sparing between a C-arm linac and an O-ring linac in a SIB-VMAT sarcoma treatment for a pregnant patient: A technical note and case report.

Purpose: To compare the effect of two linacs designs on fetal dose sparing on a pregnant patient, including estimation of the fetal dose, and the effect of a lead apron.

Methods: A patient with a high-grade sarcoma located in the right knee/lower thigh was prescribed 51 Gy (1.7 Gy/Fx) with a simultaneous-integrated-boost (SIB) of 60 Gy to a smaller volume, starting in the 26th gestational week.

Hierarchical assembly and modeling of DNA nanotube networks using Y-shaped DNA origami seeds.

DNA nanotechnology offers many means to synthesize custom nanostructured materials from the ground up in a hierarchical fashion. While the assembly of DNA nanostructures from small (nanometer-scale) monomeric components has been studied extensively, how the hierarchical assembly of rigid or semi-flexible units produces multi-micron scale structures is less understood. Here we demonstrate a mechanism for assembling micron-scale semi-flexible DNA nanotubes into extended structures.

Influence of air mapping errors on the dosimetric accuracy of prostate CBCT-guided online adaptive radiation therapy.

Purpose: CBCT-guided online adaptive radiotherapy (oART) plans presently utilize daily synthetic CTs (sCT) that are automatically generated using deformable registration algorithms. These algorithms may have poor performance at reproducing variable volumes of gas present during treatment. Therefore, we have analyzed the air mapping error between the daily CBCTs and the corresponding sCT and explored its dosimetric effect on oART plan calculation.

Association of socio-economic status and ethnicity with mortality and morbidity of premature infants admitted to neonatal intensive care in South Auckland, New Zealand.

Aim: Socio-economic status (SES) and ethnicity have been associated with worse maternal and fetal outcomes. Counties Manukau is a region of New Zealand which has a high portion of the population living in areas of low SES and has a higher population of ethnic minorities (Pacific Islander, Asian and Maaori). To determine whether SES and ethnicity are associated with worse mortality and morbidity in preterm infants in Counties Manukau Hospital, New Zealand.

Effectiveness of text message interventions with different behavior change techniques on alcohol consumption among young adults: a five-arm randomized controlled trial.

Aims: This studys aim is to test the effectiveness of five interventions each utilizing a unique set of behavior change techniques on reducing alcohol consumption at 3 and 6 months among young adults with hazardous drinking.

Design, Setting And Participants: This study used a five-arm parallel randomized controlled trial with 3- and 6-month follow-ups. Recruitment occurred at four emergency departments in Pittsburgh, PA, USA.

Surface engineering and the application of laser-based processes to stents - A review of the latest development.

Late in-stent thrombus and restenosis still represent two major challenges in stents' design. Surface treatment of stent is attracting attention due to the increasing importance of stenting intervention for coronary artery diseases. Several surface engineering techniques have been utilised to improve the biological response on a wide range of biomedical devices.

Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells.

Mesoscale molecular assemblies on the cell surface, such as cilia and filopodia, integrate information, control transport and amplify signals. Designer cell-surface assemblies could control these cellular functions. Such assemblies could be constructed from synthetic components ex vivo, making it possible to form such structures using modern nanoscale self-assembly and fabrication techniques, and then oriented on the cell surface.

Laser Processing of Hard and Ultra-Hard Materials for Micro-Machining and Surface Engineering Applications.

Polycrystalline diamonds, polycrystalline cubic boron nitrides and tungsten carbides are considered difficult to process due to their superior mechanical (hardness, toughness) and wear properties. This paper aims to review the recent progress in the use of lasers to texture hard and ultra-hard materials to a high and reproducible quality. The effect of wavelength, beam type, pulse duration, fluence, and scanning speed is extensively reviewed, and the resulting laser mechanisms, induced damage, surface integrity, and existing challenges discussed.

Ultrasonic Deposition of Carbon Nanotubes on Polycrystalline Cubic Boron Nitride Composites.

Polycrystalline cubic boron nitride (PcBN) are super-hard materials with high hardness and excellent abrasive resistance, widely used in cutting tools for precision machining of automotive and aerospace parts; however, their brittle properties make them prone to premature failure. Coatings are often applied to PcBN to extend their range of applicability and durability. Conventional coating methods are limited to the thickness range of a few hundred nanometres, poor adhesion to the substrate, and limited stability under ambient conditions.

Fault Diagnosis by Multisensor Data: A Data-Driven Approach Based on Spectral Clustering and Pairwise Constraints.

This paper deals with clustering based on feature selection of multisensor data in high-dimensional space. Spectral clustering algorithms are efficient tools in signal processing for grouping datasets sampled by multisensor systems for fault diagnosis. The effectiveness of spectral clustering stems from constructing an embedding space based on an affinity matrix.

Reconfiguring DNA Nanotube Architectures Selective Regulation of Terminating Structures.

Molecular assemblies inside cells often undergo structural reconfiguration in response to stimuli to alter their function. Adaptive reconfiguration of cytoskeletal networks, for example, enables cellular shape change, movement, and cargo transport and plays a key role in driving complex processes such as division and differentiation. The cellular cytoskeleton is a self-assembling polymer network composed of simple filaments, so reconfiguration often occurs through the rearrangement of its component filaments' connectivities.

Macromolecular modeling and design in Rosetta: recent methods and frameworks.

The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities.

ACR-ASTRO Practice Parameter for the Performance of Stereotactic Body Radiation Therapy.

Aim/objectives/background: To standardize the practice of stereotactic body radiation therapy (SBRT), the American College of Radiology (ACR) and the American Society for Radiation Oncology (ASTRO) cooperatively developed the practice parameter for SBRT. SBRT is a treatment technique that delivers radiation dose to a well-defined extracranial target in 5 fractions or less and usually employs a higher dose per fraction than used in conventional radiation.

Methods: The ACR-ASTRO Practice Parameter for the Performance of Stereotactic Body Radiation Therapy was revised according to the process described on the ACR website ("The Process for Developing ACR Practice Parameters and Technical Standards," www.

Multiscale Numerical and Experimental Analysis of Tribological Performance of GO Coating on Steel Substrates.

Herein, nano-tribological behaviour of graphene oxide (GO) coatings is evaluated by a combination of nanoscale frictional performance and adhesion, as well as macroscale numerical modelling. A suite of characterisation techniques including atomic force microscopy (AFM) and optical interferometry are used to characterise the coatings at the asperity level. Numerical modelling is employed to consider the effectiveness of the coatings at the conjunction level.

Transurethral endoscopic approach for large bladder diverticula: Evaluation of a large series.

Objective: To present the results of the largest series of patients with bladder diverticula > 4 cm managed with an endoscopic approach and give tips about the execution of the procedure.

Materials And Methods: Data of male patients undergone the endoscopic approach for an acquired bladder diverticula > 4 cm from December 2004 to August 2018 were prospectively collected and retrospectively analyzed. The description of the monopolar and bipolar techniques are provided.

Opioid use patterns and risk characteristics among injured patients.

Injured patients are at risk for prolonged opioid use after discharge from care. Limited evidence exists regarding how continued opioid use may be related to opioid medication misuse and opioid use disorder (OUD) following injury. This pilot study characterized opioid consumption patterns, health characteristics, and substance use among patients with active prescriptions for opioid medications following injury care.

"Running Trains" and "Sexing-In": The Functions of Sex Within Adolescent Gangs.

Gang members are exposed to unique sexual risks, yet little work has explored the influence of gang social norms. This study examines the functions and meanings of sex within gangs, with a specific focus on the ways in which sex is used to reinforce gang membership and norms, gender roles, and group cohesion. We conducted 58 semi-structured interviews with adolescent members of six gangs.

Chiral switching in biomineral suprastructures induced by homochiral l-amino acid.

How homochiral l-biomolecules in nature induce a chiral switch in biomineralized architectures is unknown, although chiral switching is common in many calcium carbonate-hardened structures found in marine and terrestrial organisms. We created hierarchically organized, chiral biomineral structures of calcium carbonate, whose chirality can be switched by a single l-enantiomer of an amino acid. The control of this chiral switching involves two stages: a calcium carbonate (vaterite) platelet layer inclination stage, followed by a platelet layer rotation stage, the latter stage being responsible for successional chiral switching events within the biomineralized structures.

Nanostructure, osteopontin, and mechanical properties of calcitic avian eggshell.

Avian (and formerly dinosaur) eggshells form a hard, protective biomineralized chamber for embryonic growth-an evolutionary strategy that has existed for hundreds of millions of years. We show in the calcitic chicken eggshell how the mineral and organic phases organize hierarchically across different length scales and how variation in nanostructure across the shell thickness modifies its hardness, elastic modulus, and dissolution properties. We also show that the nanostructure changes during egg incubation, weakening the shell for chick hatching.

A Parametric Rosetta Energy Function Analysis with LK Peptides on SAM Surfaces.

Although structures have been determined for many soluble proteins and an increasing number of membrane proteins, experimental structure determination methods are limited for complexes of proteins and solid surfaces. An economical alternative or complement to experimental structure determination is molecular simulation. Rosetta is one software suite that models protein-surface interactions, but Rosetta is normally benchmarked on soluble proteins.

The Association Between Daily Posttraumatic Stress Symptoms and Pain Over the First 14 Days After Injury: An Experience Sampling Study.

Objectives: Psychosocial factors and responses to injury modify the transition from acute to chronic pain. Specifically, posttraumatic stress disorder (PTSD) symptoms (reexperiencing, avoidance, and hyperarousal symptoms) exacerbate and cooccur with chronic pain. Yet no study has prospectively considered the associations among these psychological processes and pain reports using experience sampling methods (ESMs) during the acute aftermath of injury.

Enteral Feeding as an Adjunct to Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy.

Background: Withholding enteral feedings during hypothermia lacks supporting evidence.

Objectives: We aimed to determine if minimal enteral nutrition (MEN) during hypothermia in patients with hypoxic-ischemic encephalopathy was associated with a reduced duration of parenteral nutrition, time to full oral feeds, and length of stay, but would not be associated with increased systemic inflammation or feeding complications.

Methods: We performed a pilot, retrospective, matched case-control study within the Florida Neonatal Neurologic Network from December 2012 to May 2016 of patients who received MEN during hypothermia (n = 17) versus those who were not fed (n = 17).

Can Neonatal Brain MRI be Performed during Active Cooling?

Objective: Due to logistical constraints, physicians traditionally delay diagnostic imaging for neonatal hypoxic-ischemic encephalopathy (HIE) until the neonate has completed all 72 hours of therapeutic hypothermia and rewarming. In some cases, neonates may require neuroimaging before 72 hours has passed.

Study Design: We present a case in which an MRI was acquired during active hypothermia.