Independent factors for the development of vasoplegic syndrome in patients undergoing coronary artery bypass surgery.

Objective: Vasoplegic syndrome remains a common complication of cardiac surgery. It has serious implications for the healthcare system and individual patients, as it leads to rising healthcare costs and higher mortality. A better understanding of factors triggering vasoplegic syndrome is essential for the development of effective prevention strategies.

Fates of selected pharmaceuticals in a large recirculated mesocosm with a pond and bank filtration.

Pharmaceuticals such as carbamazepine (CBZ), sulfamethoxazole (SMX) and diclofenac (DCF) are detected at a high frequency in the aquatic environment. The fates of these compounds in bank filtration (BF), a nature-based water treatment system, have been extensively studied, mainly in batch and laboratory column studies. This study, for the first time, investigated the fates of CBZ, SMX and DCF in a large recirculated mesocosm with a pond and subsequent BF.

Transformation of potentially persistent and mobile organic micropollutants in column experiments.

The occurrence of potentially persistent and mobile (PM) organic micropollutants (OMP) in the aquatic environment is recognized as a severe threat to water resources and drinking water suppliers. The current study investigated long-term fate (persistency and bio-transformation) of several emerging contaminants in a simulated bank filtration (BF) for the first time. In parallel, four sand column systems were operated with groundwater and continuously spiked with an average concentration of 1 μg/L for 24 OMP.

Entangling a Hole Spin with a Time-Bin Photon: A Waveguide Approach for Quantum Dot Sources of Multiphoton Entanglement.

Deterministic sources of multiphoton entanglement are highly attractive for quantum information processing but are challenging to realize experimentally. In this Letter, we demonstrate a route toward a scaleable source of time-bin encoded Greenberger-Horne-Zeilinger and linear cluster states from a solid-state quantum dot embedded in a nanophotonic crystal waveguide. By utilizing a self-stabilizing double-pass interferometer, we measure a spin-photon Bell state with (67.

Health and functional status of tiotropium/olodaterol-treated patients with COPD: results from the AERIAL® non-interventional study.

Patients with COPD often have reduced physical activity, which can impair health status. Real-world data can provide valuable information on the health and functional status of patients with COPD treated with tiotropium/olodaterol.  AERIAL (ClinicalTrials.

Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain.

Modification with SUMO regulates many eukaryotic proteins. Down-regulation of sumoylated forms of proteins involves either their desumoylation, and hence recycling of the unmodified form, or their proteolytic targeting by ubiquitin ligases that recognize their SUMO modification (termed STUbL or ULS). STUbL enzymes such as Uls1 and Slx5-Slx8 in budding yeast or RNF4 and Arkadia/RNF111 in humans bear multiple SUMO interaction motifs to recognize substrates carrying poly-SUMO chains.

Assessment of physical functioning and handling of tiotropium/olodaterol Respimat in patients with COPD in a real-world clinical setting.

Background: Patients with chronic obstructive pulmonary disease (COPD) show signs of reduced physical activity from the early stages of the disease, impacting morbidity and mortality. Data suggest treatment with tiotropium, a long-acting muscarinic antagonist, and olodaterol, a long-acting ß-agonist (LABA), as monotherapies and in combination, increases exercise capacity. This study assessed the effects of fixed-dose tiotropium/olodaterol (delivered via Respimat) on physical function in Global Initiative for Chronic Obstructive Lung Disease A-D patients requiring long-acting dual bronchodilation treatment in a real-world setting.

Transport and retention of differently coated CeO nanoparticles in saturated sediment columns under laboratory and near-natural conditions.

Where surface-functionalized engineered nanoparticles (NP) occur in drinking water catchments, understanding their transport within and between environmental compartments such as surface water and groundwater is crucial for risk assessment of drinking water resources. The transport of NP is mainly controlled by (i) their surface properties, (ii) water chemistry, and (iii) surface properties of the stationary phase. Therefore, functionalization of NP surfaces by organic coatings may change their fate in the environment.

Methods to study SUMO dynamics in yeast.

Covalent modification of proteins with the small ubiquitin-related modifier (SUMO) is found in all eukaryotes and is involved in many important processes. SUMO attachment may change interaction properties, subcellular localization, or stability of a modified protein. Usually, only a small fraction of a protein is modified at a given time because sumoylation is a highly dynamic process.

Colloidal stabilization of CeO nanomaterials with polyacrylic acid, polyvinyl alcohol or natural organic matter.

Engineered nanomaterials (ENM) such as nano-sized cerium dioxide (CeO) are increasingly applied. Meanwhile, concerns on their environmental fate are rising. Understanding the fate of ENM within and between environmental compartments such as surface water and groundwater is crucial for the protection of drinking water resources.

Definition, clinical classification and initial diagnosis of pulmonary hypertension: Updated recommendations from the Cologne Consensus Conference 2018.

In the summer of 2016, delegates from the German Society of Cardiology (DGK), the German Respiratory Society (DGP), and the German Society of Pediatric Cardiology (DGPK) met in Cologne, Germany, to define consensus-based practice recommendations for the management of patients with pulmonary hypertension (PH). These recommendations were built on the 2015 European Pulmonary Hypertension guidelines, aiming at their practical implementation, considering country-specific issues, and including new evidence, where available. To this end, a number of working groups was initiated, one of which was specifically dedicated to the definition, clinical classification and initial diagnosis of PH.

Phenotypes of organ involvement in sarcoidosis.

Sarcoidosis is a highly variable, systemic granulomatous disease of hitherto unknown aetiology. The GenPhenReSa (Genotype-Phenotype Relationship in Sarcoidosis) project represents a European multicentre study to investigate the influence of genotype on disease phenotypes in sarcoidosis.The baseline phenotype module of GenPhenReSa comprised 2163 Caucasian patients with sarcoidosis who were phenotyped at 31 study centres according to a standardised protocol.

Ultrafast isomerization in acetylene dication after carbon K-shell ionization.

Ultrafast proton migration and isomerization are key processes for acetylene and its ions. However, the mechanism for ultrafast isomerization of acetylene [HCCH] to vinylidene [HCC] dication remains nebulous. Theoretical studies show a large potential barrier ( > 2 eV) for isomerization on low-lying dicationic states, implying picosecond or longer isomerization timescales.

Subduction zone forearc serpentinites as incubators for deep microbial life.

Serpentinization-fueled systems in the cool, hydrated forearc mantle of subduction zones may provide an environment that supports deep chemolithoautotrophic life. Here, we examine serpentinite clasts expelled from mud volcanoes above the Izu-Bonin-Mariana subduction zone forearc (Pacific Ocean) that contain complex organic matter and nanosized Ni-Fe alloys. Using time-of-flight secondary ion mass spectrometry and Raman spectroscopy, we determined that the organic matter consists of a mixture of aliphatic and aromatic compounds and functional groups such as amides.

[Clinical classification and initial diagnosis of pulmonary hypertension: recommendations of the Cologne Consensus Conference 2016].

The 2015 European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension are also valid for Germany. The guidelines contain detailed information about the clinical classification and diagnosis of pulmonary hypertension, and furthermore provide novel recommendations for risk stratification and follow-up assessments. However, the practical implementation of the European Guidelines in Germany requires the consideration of several country-specific issues and already existing novel data.

Probe of Multielectron Dynamics in Xenon by Caustics in High-Order Harmonic Generation.

We investigated the giant resonance in xenon by high-order harmonic generation spectroscopy driven by a two-color field. The addition of a nonperturbative second harmonic component parallel to the driving field breaks the symmetry between neighboring subcycles resulting in the appearance of spectral caustics at two distinct cutoff energies. By controlling the phase delay between the two color components it is possible to tailor the harmonic emission in order to amplify and isolate the spectral feature of interest.

Differences in emotional responses in living and deceased donor kidney transplant patients.

Background: The psychological functioning of living donor (LD) and deceased donor (DD) recipients are important factors for emotional adjustment to transplantation. This study investigated differences in medical, sociodemographic and emotional factors between these two groups.

Methods: A total of 241 kidney transplant recipients (68 LD, 173 DD) completed questionnaires on emotional and behavioural responses to transplantation, including quality of life, anxiety and depression, social support and experience with immunosuppressive medication.

The Efficacy of Body-Oriented Yoga in Mental Disorders–A Systematic Review and Meta-Analysis.

Background: The efficacy of body-oriented yoga in the treatment of mental disorders has been investigated in numerous studies. This article is a systematic review and meta-analysis of the relevant publications.

Methods: All studies in which the efficacy of hatha-yoga, i.

Cardiovascular magnetic resonance-guided diagnosis of cardiac affection in a Caucasian sarcoidosis population.

Background: Clinically evidenced cardiac involvement in systemic sarcoidosis occurs in approximately 5% of patients, whereas post-mortem examinations identify cardiac sarcoidosis in over 60% of cases.

Objective: Given the inconsistency of diagnostic approaches, we took aim at prospectively investigating the prevalence of cardiac sarcoidosis by cardiovascular magnetic resonance (CMR) in a primary Caucasian population and at correlating the results with standard clinical parameters.

Methods: 188 patients with histologically proven sarcoidosis were included, provenient from the local pneumological department and a national sarcoidosis self-help association.

Physician reported adherence to immunosuppressants in renal transplant patients: Prevalence, agreement, and correlates.

Objective: Adherence to immunosuppressants (IS) is crucial to prevent allograft rejection. Even though there is evidence that non-adherence to IS among kidney transplant recipients is common, it is rarely routinely assessed in clinical practice. Especially, little is known about how physicians estimate patients' adherence to IS medication.

Solution Equilibrium Titration for High-Throughput Affinity Estimation of Unpurified Antibodies and Antibody Fragments.

The generation of therapeutic antibodies with extremely high affinities down to the low picomolar range is today feasible with state-of-the art recombinant technologies. However, reliable and efficient identification of lead candidates with the desired affinity from a pool of thousands of antibody clones remains a challenge. Here, we describe a high-throughput procedure that allows reliable affinity screening of unpurified immunoglobulin G or antibody fragments.