A randomized, double-blind trial of repetitive transcranial magnetic stimulation in obsessive-compulsive disorder with three-month follow-up.

Recent findings indicate that the motor and premotor cortices are hyperexcitable in obsessive-compulsive disorder (OCD). The authors have performed the first randomized, double-blind clinical trial of repetitive transcranial magnetic stimulation (rTMS) in OCD, with a 3-month follow-up. OCD patients (N=22) were assigned to either 2 weeks of active or sham rTMS to the supplementary motor area bilaterally.