Publications by authors named "Pablo Thomas-Dupont"
Article Synopsis
- Irritable bowel syndrome (IBS) is a gut-brain disorder linked to changes in the gut microbiome, specifically involving the yeast Saccharomyces cerevisiae, but the significance of Anti-Saccharomyces cerevisiae antibodies (ASCA) in IBS is still unclear.
- * A study with 800 participants (400 IBS patients and 400 healthy controls) aimed to see if ASCA could differentiate IBS patients from healthy individuals by measuring ASCA IgG levels.
- * The results showed no significant difference in ASCA IgG levels between IBS patients and healthy controls, indicating that ASCA may not be a useful biomarker for IBS diagnosis or its severity.
Contribution of MicroRNAs in the Development of Irritable Bowel Syndrome Symptoms.
J Gastrointestin Liver Dis
June 2023
Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder defined by disturbances in bowel habits and abdominal pain, in the absence of known organic pathology that affects between 5 to 10% of healthy populations. Despite improvements in detection and treatment, the pathogenesis of IBS has not been clarified. Several microRNAs (miRNAs) are involved in the pathogenesis of IBS through increased intestinal permeability, inflammation, and modulation of visceral hyperalgesia, and they may have the potential to be used as biomarkers and therapeutic targets.
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- Irritable Bowel Syndrome (IBS) is a chronic condition affecting the digestive system, and it is linked to low-grade inflammation and obesity, with a higher prevalence in obese patients (up to 31%).
- In a study, researchers analyzed serum samples from 79 IBS patients and 35 healthy controls to assess the levels of inflammatory and immunological molecules in relation to Body Mass Index (BMI).
- They found significantly higher levels of the complement proteins C3 and C4 in IBS patients, particularly in those with IBS-M and IBS-D subtypes, along with a positive correlation between C3 and CRP levels and BMI, highlighting a potential link between obesity-related inflammation and IBS symptoms.
Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver characterized by parenchymal destruction, hypergammaglobulinemia, specific autoantibody production, and hepatic fibrosis and necrosis. Murine models of AIH have been described; however, little is known about the immunologic mechanisms of tissue destruction. In this study, a new murine model of type 2 AIH was developed using recombinant human cytochrome P450 (CYP) 2D6 emulsified with complete Freund's adjuvant (CFA).
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- The study focused on the role of interleukin 17 (IL-17) and IL-17-producing cells in the disease progression of dengue virus (DENV) infections.
- Researchers analyzed 152 blood samples from dengue patients, identifying higher levels of IL-17A and IL-22 in those with the more severe form known as dengue hemorrhagic fever (DHF) compared to dengue fever (DF) and healthy controls.
- A strong correlation was found between IL-17A and IL-23 levels, suggesting that IL-17-producing cells contribute significantly to the immune response in DHF patients, indicating their potential importance in understanding and treating dengue infections.
Unlabelled: Background and aims. Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver in which the immunological mechanisms involved in tissue destruction and/or repair are still unclear. Different pro-inflammatory cytokines have been shown to play a determinant role in AIH pathogenesis.
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