Publications by authors named "Pablo Sousa-Casasnovas"
Objectives: The large number of infected patients requiring mechanical ventilation has led to the postponement of scheduled neurosurgical procedures during the first wave of the COVID-19 pandemic. The aims of this study were to investigate the factors that influence the decision to postpone scheduled neurosurgical procedures and to evaluate the effect of the restriction in scheduled surgery adopted to deal with the first outbreak of the COVID-19 pandemic in Spain on the outcome of patients awaiting surgery.
Design: This was an observational retrospective study.
Objective: To assess the effect of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients in Spain.
Settings: The initial flood of COVID-19 patients overwhelmed an unprepared healthcare system. Different measures were taken to deal with this overburden.
Prognostic value of the pulse pressure amplitudes, time to reach the plateau and the slope obtained in the lumbar infusion test for the study of idiophatic normal pressure hydrocephalus.
Neurocirugia (Astur : Engl Ed)
May 2022
Background And Objective: To study the prognostic value of the resistance to the cerebrospinal fluid outflow (Rout) obtained in the lumbar infusion test in idiopathic normal pressure hydrocephalus (iNPH), as well as the pulse pressure amplitudes in the different periods of the test and other new variables extracted by Neuropicture® software.
Material And Methods: Patients with 'probable iNPH' who underwent a lumbar infusion test were retrospectively revised. The positive predictive values (PPV) of the cutoff point of the best prognostic accuracy of the Rout, the basal pulse pressure amplitude (AMPo), the pulse pressure amplitude during the first 10 min (AMP), the plateau pulse pressure amplitude (AMPmes), the Rout pulse pressure amplitude (AMP), the time to reach the plateau (T), and the slope until reaching the plateau were determined.
Prognostic value of the pulse pressure amplitudes, time to reach the plateau and the slope obtained in the lumbar infusion test for the study of idiophatic normal pressure hydrocephalus.
Neurocirugia (Astur : Engl Ed)
April 2021
Background And Objective: To study the prognostic value of the resistance to the cerebrospinal fluid outflow (Rout) obtained in the lumbar infusion test in idiopathic normal pressure hydrocephalus (iNPH), as well as the pulse pressure amplitudes in the different periods of the test and other new variables extracted by Neuropicture® software.
Material And Methods: Patients with ́probable iNPH́ who underwent a lumbar infusion test were retrospectively revised. The positive predictive values (PPV) of the cutoff point of the best prognostic accuracy of the Rout, the basal pulse pressure amplitude (AMP0), the pulse pressure amplitude during the first 10minutes (AMP), the plateau pulse pressure amplitude (AMPmes), the Rout pulse pressure amplitude (AMP), the time to reach the plateau (T), and the slope until reaching the plateau were determined.
The distribution and role of tumor-infiltrating leucocytes in glioblastoma (GBM) remain largely unknown. Here, we investigated the cellular composition of 55 primary (adult) GBM samples by flow cytometry and correlated the tumor immune profile with patient features at diagnosis and outcome. GBM single-cell suspensions were stained at diagnosis (n = 44) and recurrence following radiotherapy and chemotherapy (n = 11) with a panel of 8-color monoclonal antibody combinations for the identification and enumeration of (GFAP CD45 ) tumor and normal astrocytic cells, infiltrating myeloid cells -i.
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- Abdominal pseudocysts are a rare complication of ventriculoperitoneal shunts for cerebrospinal fluid (CSF), and their causes, diagnosis, and treatment methods are still debated since their first identification in 1954.
- The most common signs of pseudocysts are vague abdominal symptoms, often linked to infections in the CSF shunt system, which require antibiotic treatment and possible changes to the shunt itself.
- The proposed treatment approach in this review aims to minimize recurrence rates and considers various complications related to the shunt, highlighting the need for a careful, systematic management strategy.
Article Synopsis
- The study aimed to identify radiologic indicators that could predict positive results in lumbar infusion tests for diagnosing idiopathic normal pressure hydrocephalus, in order to avoid invasive testing.
- Researchers analyzed 107 patients and found that specific imaging features, such as an acute callosal angle and the width of temporal horns, were significantly associated with positive CSF outflow resistance.
- High positive predictive values (>80%) for certain radiological markers suggest that the lumbar infusion test may be unnecessary if those indicators are present; however, if some markers are negative, the test should still be conducted.