Ménétrier disease: a rare cause of severe chronic diarrhea difficult to diagnose with response to treatment with octreotide.

We present the case of a 71-year-old male with difficult to manage severe chronic diarrhea, who after multiple tests was finally diagnosed with Ménétrier's disease and had clinical improvement with treatment with intramuscular octreotide. A high degree of clinical suspicion is essential to diagnose this entity, exclude similar entities and the correlation of clinical, analytical, endoscopic, radiological and histological data.

Acute pancreatitis due to osteosarcoma metastasis.

We present the case of a young patient with acute pancreatitis (AP) secondary to osteosarcoma metastasis. It is necessary to assess tumor etiology in the study of any acute pancreatitis without clear cause. Pancreatic metastases are rare and difficult to diagnose and differentiate from other primary tumors such as neuroendocrine tumors (NET).

Primary adenocarcinoma of the fourth portion of the duodenum, an unsuspected diagnosis.

Small bowel adenocarcinoma is a rare tumor accounting for only 0.3-0.4% of all gastrointestinal tumors, with duodenal adenocarcinoma being the most common subtype.

Tofacitinib, a useful option for the treatment of pyoderma gangrenosum in an ulcerative colitis patient.

Pyoderma gangrenosum (PG) is a difficult-to-manage ulcero-necrotizing dermatosis associated with inflammatory bowel disease (IBD). In this article, we report a refractory PG in a patient with severe ulcerative colitis (UC) that responded to tofacitinib 10 mg/12 h.