Clinical experience with daptomycin for the treatment of patients with knee and hip periprosthetic joint infections.

Objectives: To investigate the clinical efficacy and safety of daptomycin in the treatment of hip and knee periprosthetic joint infections (PJIs).

Methods: We completed a retrospective review of all patients in our institution (n=20) who were treated with daptomycin for hip or knee PJI, over the 36 month period from January 2008 until December 2010.

Results: Infection types included eight cases with acute infections, nine cases of chronic infection and three cases of positive intraoperative cultures.