Evaluating AI Competence in Specialized Medicine: Comparative Analysis of ChatGPT and Neurologists in a Neurology Specialist Examination in Spain.

Background: With the rapid advancement of artificial intelligence (AI) in various fields, evaluating its application in specialized medical contexts becomes crucial. ChatGPT, a large language model developed by OpenAI, has shown potential in diverse applications, including medicine.

Objective: This study aims to compare the performance of ChatGPT with that of attending neurologists in a real neurology specialist examination conducted in the Valencian Community, Spain, assessing the AI's capabilities and limitations in medical knowledge.

TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.

Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced colorectal cancer, often leads to a form of chemotherapy-induced peripheral neuropathy characterized by mechanical and cold hypersensitivity. Current therapies for chemotherapy-induced peripheral neuropathy are ineffective, often leading to the cessation of treatment.