Publications by authors named "Pablo Rene Costanzo"
Introduction And Objectives: Chronic obstructive pulmonary disease (COPD) frequently coexists with other comorbidities, including hypogonadism. However, the association between COPD severity and hypogonadism remains controversial. This study aimed to evaluate this association and compare the clinical characteristics of hypogonadal and eugonadal COPD patients.
View Article and Find Full Text PDFArticle Synopsis
- Hypogonadism is commonly found in men with chronic obstructive pulmonary disease (COPD), with this study aiming to compare its prevalence in men with and without the condition.
- The study involved 134 men with stable COPD and 70 age-matched control men, finding that 41.8% of COPD patients had hypogonadism compared to just 10.0% in non-COPD men.
- Results indicate that COPD significantly increases the likelihood of hypogonadism, especially in more severe cases, suggesting the need for routine screening of hormonal levels in COPD patients.
Purpose: To evaluate the effect of teriparatide (TPTD) on bone mineral density (BMD) and bone markers under clinical practice conditions. To assess whether the results in real-life match those published in clinical trials.
Methods: Cross-sectional study of postmenopausal women treated with TPTD for at least 12 months.
A worldwide high prevalence of vitamin D (VD) deficiency has become of growing concern because of potential adverse effects on human health, including pregnant women and their offsprings. Beyond its classical function as a regulator of calcium and phosphate metabolism, together with its fundamental role in bone health in every stage of life, its deficiency has been associated to multiple adverse health effects. The classic effects of VD deficiency in pregnancy and neonates have been late hypocalcemia and nutritional rickets.
View Article and Find Full Text PDFPurpose: Vitamin D (VD) acts on sperm motility, capacitation and survival but its role in steroidogenesis is less clear. Aims: To analyze seasonal variations in sex steroids and VD in a healthy male population.
Materials And Methods: Twenty-nine healthy males, 34.
We report the case of a 45-year-old man with a history of Klinefelter syndrome undergoing testosterone replacement therapy, and with type 2 diabetes treated with metformin with poor metabolic control. When vildagliptin was added to his treatment, he presented hypoglycemia after the testosterone injection. We highlight this not widely reported drug interaction between hypoglycemic agents and testosterone.
View Article and Find Full Text PDFObjectives: To evaluate the characteristics of presentation, biochemical profile, and etiology of gynecomastia in adults.
Methods: Medical records of 237 men aged 18-85 years with gynecomastia were evaluated.
Results: Highest prevalence of gynecomastia was observed between 21 and 30 years (n = 74; 31.
We present a 27-year-old woman with an adrenal oncocytoma. This is a very rare entity. We provide a review of the clinical, biochemical and pathological features of cases reported in the literature.
View Article and Find Full Text PDFObjective: To analyze the presentation, follow-up and evolution of differentiated thyroid cancer (DTC) detected during pregnancy.
Subjects And Methods: Twenty nine women with DTC detected during pregnancy were analyzed. Group I (n = 13) was seen during pregnancy and DTC was diagnosed during gestation; detection of the nodule occurred during pregnancy (first trimester).