Publications by authors named "Pablo Pichardo-Romero"
Introduction: Cardiovascular disease is the main cause of mortality worldwide. In women, its incidence increases at the sixth decade of life, coinciding with postmenopause. Whether this effect is due to menopause-related hormonal changes is not known.
View Article and Find Full Text PDFBackground: The standard of care for advanced-stage laryngeal cancer is combined treatment (chemo-radiotherapy). However, the complications with this treatment are not few, mainly in swallowing. Conservative laryngeal surgery remains an effective alternative for cancer control without the complications of chemo-radiotherapy.
View Article and Find Full Text PDFBackground And Aims: Approximately 85% of patients with cancer suffer severe metastatic bone pain for which radionuclide therapy has been employed for pain palliation. We undertook this study to evaluate the pain relief effect of (153)Sm-EDTMP in Mexican patients with severe and painful bone metastases from mainly prostate, breast, and renal cancer and other malignancies.
Methods: Patients (277) with intense sustained pain caused by bone metastases were referred to the Nuclear Medicine Department of the Oncology Hospital of the Mexican Social Security Institute.
Article Synopsis
- Patients with cold thyroid nodules that appear benign or undetermined may benefit from follow-up surveillance, and 99mTc-tetrofosmin scans (99mTc-TS) can help determine the need for surgery.
- The study involved 86 patients undergoing surgery, assessing the effectiveness of 99mTc-TS in predicting cancer presence by comparing scan results with histopathological findings.
- Results indicated that 99mTc-TS has a high negative predictive value (88.46%), suggesting that a lack of uptake on the scan strongly indicates a benign condition, although specificity is lower, meaning some false positives may occur.
Background: The gastrin-releasing peptide receptor (GRP-R) is expressed in several normal human tissues and is overexpressed in various human tumors including breast, prostate, small-cell lung cancer and pancreatic cancer. Recently, 99mTc-EDDA/HYNIC-[Lys]-bombesin (99mTc-HYNIC-BN) was reported as a radiopharmaceutical with high stability in human serum, specific cell GRP-R binding and rapid cell internalization.
Aim: The aim of this study was to determine the biokinetics and dosimetry of 99mTc-HYNIC-BN and the feasibility of using this radiopharmaceutical to image GRP-R in four early breast cancer patients and seven healthy women.
Background: Radioimmunotherapy is a molecular targeting treatment for high-risk leukemia and lymphoma. Rhenium-188-labeled anti-CD66 monoclonal antibody has been used successfully in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome. Our aim was to establish the biokinetics of (188)Re-anti-CD20 in patients and to evaluate its dosimetry as a target-specific radiopharmaceutical for non-Hodgkin's lymphoma (NHL) radioimmunotherapy.
View Article and Find Full Text PDFMost patients with invasive squamous cell carcinoma of the penis do not have inguinal node metastasis at the time of diagnosis and 50% of those having palpable nodes are inflammatory. Penis cancer (PC) treatment implies resection of the primary tumor and inguinal lymphadenectomy; nevertheless, morbidity related to this procedure is high and its usefulness may be questioned in patients without metastasis in dissected nodes. Lymphatic mapping with sentinel node biopsy (LMSNB) is a valid alternative, useful in other neoplasias.
View Article and Find Full Text PDFObjective: To present the characteristics of women with early breast cancer and clinically negative ganglia who were submitted to LM and SLNB in order to select the positive cases for axilar dissection and to identify the negative cases.
Material And Methods: Cases included patients who attended the Breast Tumor Service of the Oncology Hospital of the National Medical Center of the Mexican Social Security Institute from March 1, 2002, to April 30, 2004. Women with early breast cancer and clinically negative ganglia (N0) were included, with out previous treatment and without previous biopsies.
Article Synopsis
- In patients with oral cavity epidermoid cancer, sentinel node (SN) biopsy can be advantageous compared to traditional neck dissection, potentially avoiding unnecessary surgeries.
- A study of 48 patients revealed that tumor factors like T stage, location, thickness, and the number of SN identified can indicate the likelihood of metastasis in non-sentinel nodes.
- The combined use of blue dye and Rhenium colloid for SN mapping showed high success rates, and identifying three or more SNs was linked to a decreased risk of metastasis outside the primary drainage area.
Introduction: Several advances have been made in the management of hyperparathyroidism. The preoperative sestamibi scan appears to have revolutionized the entire approach to parathyroid surgery including minimally invasive parathyroidectomy. Gamma probe is a useful tool that complements a well performed localization of parathyroid adenomas.
View Article and Find Full Text PDFObjective: To determine the effectiveness of radioimmunoscintigraphy (RIC) with 111In-CYT-103 in detecting the extension of malignant disease in patients surgically treated for colorectal adenocarcinoma under suspicion of recurrence in comparison to CT scan (computed tomography) and exploratory laparotomy.
Design: Prospective and observational study.
Material And Methods: A total of 26 patients under suspicion of recurrence, with a total of 31 lesions.