Publications by authors named "Pablo Pfister"

Background: Total or subtotal glossectomy defects cause significant functional deficits in swallowing and speech and subsequently impair patients' quality of life (QOL). Recently, the profunda artery perforator (PAP) flap has emerged as a potential alternative for reconstructing extensive glossectomy defects. While previous studies assessing recovery of neurotized anterolateral thigh (ALT) flaps in head and neck reconstruction reported superior sensory recovery, improved swallow function, and improved overall patient satisfaction in patients with neurotized flaps vs.

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Article Synopsis
  • Limited data shows that adjuvant radiochemotherapy negatively affects free flap volume in head and neck reconstruction, which is crucial for functional outcomes.
  • A systematic review analyzed 19 studies, finding that irradiated flaps had a notable average volume reduction of 9.4% compared to nonirradiated flaps six months after surgery.
  • The findings suggest that clinicians should consider the impact of radiation on flap volume during surgical planning, and future research should focus on standardized methods to optimize free flap volume for better patient results.
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In autologous breast reconstruction, a sufficient flap volume is fundamental to restore breast shape and ensure an aesthetic outcome. After mastectomy, postoperative irradiation is regularly indicated in the oncological treatment algorithm. When administering radiation therapy after autologous reconstruction, the tissue transferred is inherently irradiated.

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As the prevalence of juvenile-onset obesity rises globally, the multitude of related health consequences gain significant importance. In this context, obesity is associated with impaired cutaneous wound healing. In experimental settings, mice are the most frequently used model for investigating the effect of high-fat diet (HFD) chow on wound healing in wild-type or genetically manipulated animals, e.

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The regenerative potential of adipose-derived stromal cells (ASCs) has gained significant attention in regenerative and translational research. In the past, the extraction of these cells from adipose tissue required a multistep enzyme-based process, resulting in a heterogenous cell mix consisting of ACSs and other cells, which are jointly termed the stromal vascular fraction (SVF). More recently introduced mechanical SVF (mSVF) isolation protocols are less time-consuming and bypass regulatory concerns.

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Article Synopsis
  • - Lipedema is a chronic disorder mainly affecting women, often misdiagnosed, with unclear causes and recent research highlighting changes in macrophage behavior as a key factor in the condition.
  • - A study examined the expressions of MIF-1 and MIF-2 proteins, as well as CD74 (a receptor for these proteins), in tissue samples from lipedema patients compared to matched controls, finding significant increases in MIF-1 and CD74 levels.
  • - The findings suggest that the MIF protein family, particularly through the MIF-1-CD74 interaction, may play a crucial role in the development of lipedema, providing new insights into its underlying mechanisms.
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Background: Burn wounds pose significant challenges in medical treatment due to their devastating nature and resource-intensive requirements. Temporary coverage of burn wounds using synthetic or biological dressings allows for reepithelization before definitive skin grafting. Allogenic skin grafts have been widely used but come with drawbacks such as rejection and disease transmission.

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Objectives: Bromelain-based enzymatic debridement has emerged as a valuable option to the standard surgical intervention for debridement in burn injuries. Adverse effects on coagulation parameters after enzymatic debridement have been described. The purpose of this study was to compare the effect of enzymatic and surgical debridement on coagulation.

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Background: Hypothermia in severely burned patients is associated with a significant increase in morbidity and mortality. The use of an oesophageal heat exchanger tube (EHT) can improve perioperative body temperatures in severely burned patients. The aim of this study was to investigate the intraoperative warming effect of oesophageal heat transfer in severe burn patients.

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