Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon.

Interferons (IFN) are crucial antiviral and immunomodulatory cytokines that exert their function through the regulation of a myriad of genes, many of which are not yet characterized. Here, we reveal that lipin-2, a phosphatidic acid phosphatase whose mutations produce an autoinflammatory syndrome known as Majeed syndrome in humans, is regulated by IFN in a STAT-1-dependent manner. Lipin-2 inhibits viral replication both in vitro and in vivo.

Screening for Fabry disease in Argentina in male patients with chronic kidney disease at all stages.

We report three patients diagnosed with Fabry disease through a screening study which included individuals suffering from chronic kidney disease (CKD) at any stage. The study recruited 1740 male patients, and three Fabry patients were diagnosed, resulting in a frequency of 0.17%.

Conditioned Medium from Human Uterine Cervical Stem Cells Regulates Oxidative Stress and Angiogenesis of Retinal Pigment Epithelial Cells.

Introduction: Retinal homeostasis is essential to avoid retinal pigment epithelium (RPE) damage resulting in photoreceptor death and blindness. Mesenchymal stem cells-based cell therapy could contribute to the maintenance of the retinal homeostasis. We have explored the effect of human uterine cervical stem cells (hUCESCs)-conditioned medium (hUCESC-CM) on RPE cells under oxidative stress condition.

Human Stem Cell Transplantation for Retinal Degenerative Diseases: Where Are We Now?

: Irreversible visual impairment is mainly caused by retinal degenerative diseases such as age-related macular degeneration and retinitis pigmentosa. Stem cell research has experienced rapid progress in recent years, and researchers and clinical ophthalmologists are trying to implement this promising technology to treat retinal degeneration. The objective of this systematic review is to analyze currently available data from clinical trials applying stem cells to treat human retinal diseases.

MMP1 and MMP11 Expression in Peripheral Blood Mononuclear Cells upon Their Interaction with Breast Cancer Cells and Fibroblasts.

Tumor-infiltrating immune cells phenotype is associated with tumor progression. However, little is known about the phenotype of the peripheral blood mononuclear cells (PBMC) from breast cancer patients. We investigated MMP1 and MMP11 expression in PBMC from breast cancer patients and we analyzed gene expression changes upon their interaction with cancer cells and cancer-associated fibroblasts (CAF).

The role of lipins in innate immunity and inflammation.

Lipins are phosphatidic acid phosphatase enzymes whose cellular function in regulating lipid metabolism has been known for decades, particularly in metabolically active tissues such as adipose tissue or liver. In recent years evidence is accumulating for key regulatory roles of the lipin family in innate immune cells. Lipins may help regulate signaling through relevant immune receptors such as Toll-like receptors, and are also integral part of the cellular machinery for lipid storage in these cells, thereby modulating certain inflammatory processes.

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.

Mutations in human LPIN2 produce a disease known as Majeed syndrome, the clinical manifestations of which are ameliorated by strategies that block IL-1β or its receptor. However the role of lipin-2 during IL-1β production remains elusive. We show here that lipin-2 controls excessive IL-1β formation in primary human and mouse macrophages by several mechanisms, including activation of the inflammasome NLRP3.

[Exudative onycholysis and acute bacterial paronychia related to BIBF-1120 and paclitaxel: response to topical therapy].

A case of a 50 years-old breast cancer patient treated with weekly paclitaxel and BIBF 1120 is reported herein. At the end of the twelfth cycle of chemotherapy, the patient developed distal onycholysis with intense hyponychium serous exudates, pain and malodor in all her fingernails. It was treated with topical fusidic acid and 1% methylprednisolone aceponate two times daily, with an excellent clinical response from the first three days of treatment.

[Neuropsychological rehabilitation in patients with borderline personality disorder: a case series].

Recent research studies have been confirming the evidence that patients with personality borderline disorder (BPD) suffer significant neuropsychological disorders. Neurocognitive dysfunction of BPD seems to mainly affect the functions characteristic of the prefrontal areas that participate in information processing and management and in the regulation of complex behavioral responses. Neuropsychological disorders not only are seen in the specific tests but are also reflected and could play an important role in the clinical manifestations of borderline disorder, such as emotional dysregulation and impulsive behaviors.

[Neuropsychological dysfunctions in personality borderline disorder: detection strategies].

Introduction: Borderline personality disorder (BPD) is characterized by emotional instability and impulsivity. However, there is evidence that neurocognitive alterations have a relevant role in the clinical features of these patients. The present study investigates cognitive function in BPD in order to search for a specific profile of neuropsychological alterations.

Prevalence of and intrinsic risk factors for appendicular osteosarcoma in dogs: 179 cases (1996-2005).

Objective: To determine the prevalence of appendicular osteosarcoma (OSA) in Greyhounds compared with other breeds and identify potential intrinsic risk factors associated with development of OSA.

Design: Retrospective case series.

Animals: 179 dogs with primary appendicular OSA.

[Situation of Diseases of Compulsory Declaration (DCDs) in Navarra. 1997].

The system of Diseases of Compulsory Declaration (DCDs) encompasses, until the end of 1997, the notification of 41 transmittable infectious diseases, to which are added epidemic outbreaks of any etiology and cause. In Navarra, the DCDs are declared to the Vigilance and Epidemiological Control Section of the Public Health Institute on a weekly basis by the doctors of Primary and Specialised Care. Subsequently, the information is sent to the National Centre of Epidemiology where the data from the autonomous communities is centralised.

[Situation of Diseases of Compulsory Declaration (DCDs) in Navarra. 1998].

The System of Epidemiological Vigilance of Navarra comprises the notification of 33 transmissible infectious diseases, to which are added epidemic outbreaks of any etiology or cause. Notification to the system is carried out on a weekly basis by any doctor who suspects or diagnoses any of the processes. In our Autonomous Community, the Diseases of Compulsory Declaration (DCDs) are reported to the Section of Vigilance and Epidemiological Control of the Institute of Public Health, on a weekly basis by the doctors of Primary and Specialised Care.

[Surveillance report on Diseases of Compulsory Notification in Navarra. 1999].

The Epidemiological Surveillance System of Navarra includes the notification of 33 transmissible infectious diseases, to which epidemic outbreaks of any aetiology and cause are added. Reporting to the system is carried out on a weekly basis by every doctor who suspects or diagnoses any of these processes. In our autonomous community, Diseases of Compulsory Notification (DCN) are reported to the Section for the Control of Infectious Diseases and Outbreaks of the Public Health Institute on a weekly basis by the doctors of Primary and Specialised Care.

[Surveillance report on Diseases of Compulsory Declaration (DCD) in Navarra. 2000].

The Epidemiological Surveillance System of Navarra includes the notification of 34 transmissible infectious diseases, to which epidemic outbreaks of any aetiology and cause are added. In 2000, under the heading of diseases of respiratory transmission, 31,106 cases of flu were reported; 80% of total annual cases were reported in the first 6 weeks of the year, with a maximum in week 1 when 7,949 cases were reported. Twelve cases of meningococcal disease were reported to the system.

[Food poisoning outbreak due to the consumption of spaghetti a la carbonara caused by Salmonella enteritidis].

Introduction: This paper reports a clinico-epidemiological and microbiological investigation conducted into an outbreak of gastrointestinal infection due to Salmonella enteritidis, where the most likely food vehicle was spaghetti a la carbonara.

Methods: An historic cohort study was conducted out among persons exposed to menus at a school canteen. Data were gathered on age, sex, foods consumed and clinical symptoms.

[Extraintestinal isolation of Salmonella in chickens: epidemiologic study of 3 salmonellosis outbreaks after ingestion of raw eggs].

A taxonomic analysis of the malolactic microflora present in nine grape samples from different zones of Galicia, was carried out. Nineteen strains were isolated and identified as Lactobacillus plantarum (42%), L. brevis (10.

Renal papillary necrosis: relapsing form associated with alcoholism.

Described is a patient with recurrent renal papillary necrosis and chronic alcoholism as a possible precipitating factor. The case also demonstrates excellent recovery of renal function, despite considerable scarring of the parenchyma secondary to repeated episodes of sloughing of the papillae.

Elevated 1,25-dihydroxyvitamin D levels: occurrence with sarcoidosis with end-stage renal disease.

It is generally agreed that the kidneys are the only site of 1-hydroxylation of vitamin D and that the abnormal calcium metabolism in sarcoidosis is caused by increased production of 1,25-dihydroxyvitamin D (1,25-[OH]2D). We describe a patient with sarcoidosis with hypercalcemic nephropathy and end-stage renal disease undergoing long-term maintenance hemodialysis who was initially seen with hypercalcemia and elevated serum levels of 1,25-(OH)2D. Prednisone administration resulted in decreased serum calcium and 1,25-(OH)2D levels.

Increased sodium reabsorption in the proximal and distal tubule of caval dogs.

The effects of water diuresis, hypotonic NaCl, and hypotonic mannitol diuresis on renal sodium and water excretion were examined in normal dogs and in dogs with chronic constriction of the thoracic inferior vena cava and ascites (caval dogs). During all three diuretic states, the capacity to excrete solute-free water relative to the supply of sodium to the water clearing segment of the nephron was significantly greater in the caval dog. This finding was most evident during hypotonic NaCl diuresis but was also striking during hypotonic mannitol diuresis despite the more unfavorable gradient for sodium reabsorption at the distal tubule produced by this agent in caval dogs.