Publications by authors named "Pablo Mallaina"
Article Synopsis
- The study aimed to assess the prevalence and characteristics of transthyretin amyloid cardiomyopathy (ATTR-CM) in older patients with hypertrophic cardiomyopathy of unknown causes, amidst rising recognition of this condition due to better diagnostic techniques.
- Conducted across 20 hospitals in 11 countries, the TTRACK study included patients aged 50 and older with specific echocardiography findings, who underwent imaging tests to evaluate cardiac involvement.
- Results showed that 18.8% of patients had transthyretin amyloid cardiomyopathy, with notable findings including a correlation to symptoms of heart failure and a significant association with carpal tunnel syndrome among patients.
: Transthyretin amyloid polyneuropathy (ATTR-PN) is a fatal disease associated with substantial burden of illness. Three therapies are approved by the European Medicines Agency for the management of this rare disease. The aim of this study was to compare the total annual treatment specific cost per-patient associated with ATTR-PN in Spain.
View Article and Find Full Text PDFTransthyretin (TTR) is a tetrameric transport protein highly conserved through vertebrate evolution and synthesized in the liver, choroid plexus, and retinal pigment epithelium. TTR transports the thyroid hormone thyroxine and the retinol-binding protein (RBP) bound to retinol (vitamin A). Mutations in TTR are associated with inherited transthyretin amyloidosis (ATTRv), a progressive, debilitating disease that is ultimately fatal and is characterized by misfolding of TTR and aggregation as amyloid fibrils, predominantly leading to cardiomyopathy or polyneuropathy depending on the particular TTR mutation.
View Article and Find Full Text PDFBackground: Smoking is a major risk factor for cardiovascular disease (CVD). This multicenter, cross-sectional survey was designed to estimate the cardiovascular (CV) risk attributable to smoking using risk assessment tools, to better understand patient behaviors and characteristics related to smoking, and characterize physician practice patterns.
Methods: 1,439 smokers were recruited from Europe during 2011.